Annals of Mechnikov's Institute 2005 1
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THE CONCEPT OF STRUGGLE AGAINST INFECTION CONTAMINATIONS AT THE PRESENT STAGE
Frolov A.F.
In article the review of the literature concerning a modern state of struggle against contagions in modern condi-tions is presented. It is shown an essential role of persistent viruses in complication of an epidemic situation in the world recently. Paths of the further struggle against epidemies of dangerous infection contaminations are offered. Strat-egy of behaviour of the state in conditions of threat of modern epidemies is offered.

1-5

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CHANGE OF COMPOSITION OF THE MICROFLORA AS THE EFFICIENCY FACTOR OF APPLICATION OF MEDICAL DRUGS AT EXPERIMENTAL DISBIOSIS
Gataulin AG, Blinkova LP, Michaylova NA, Yolkina SI, Gayderov AA, Kalina NG, Gorobetc OB.
In article results of studying of spirulina influence and ciprofloxacin on a breeding of microorganisms are resulted. It is shown, that spirulina in quantity of 1 mg has caused an essential quantitative change of microorganisms. Number lac + and lac-microorganisms has compounded 10:1. However the augmentation of a spirulina dose has sharply reduced a level 1 + enterobacteria (more than in 200 times). Similar influence of the same doses of a complex of spirulina me-tabolites also has been taped in vitro concerning E.coli, Shigella, Staphyiococcus, Streptococcus. For carrying out of correction of a microflora at disbiosis an intestine it is necessary to consider features of action of the injected drug not only on a concrete microorganism, but also on its interrelation with other microflora, including, the same sort.
 
6-10

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RECOVERY FROM SEAFOODS IN NUTRIENT MEDIUMS
Schmigaleva TP, Blinkova  LP., Gorobetc OB, Muhin VA, Novikov V Y.
In work results of studying of processing waste of seafoods as components of nutrient mediums for cultivation of microorganisms are presented. It is shown, that use of the hydrolysates tested by us from waste of sea crafts in structure of nutrient agar of nutrient broth allows to evolve as the most suitable for the further studying a breakage of the shrimp, and also waste of the Kamchatka crab and kukumaria.

11-17

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WORKING OUT METHODS FOR TRANSFORMATION WASTE OF GAMAGLOBULIN MANUFACTURE IN FORM WHICH ACCESSIBLE FOR BACTERIUMS
Osolodchenkov TP, Nikolayenko VM, Bogzko MG, Schetinina VM, Schtiker LG.
Receiving regimes of nutrient basis in the way overdoing waste gamaglobuline manufacture of pancreas which let to get nutrient forms for microorganisms was worked out. You can see possibility of their using constructions of nutrient mediums.
Key words: nutrient basis, waste of manufacture, construction of mediums, cultivation

17-21

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STAPHYLOCOCCUS AUREUS
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WORKING OUT NUTRIENT MEDIUM FOR RECEIVING BIOMASS STAPHYLOCOCCUS AUREUS
Osolodchenko TP, Pasichnik TO, Nikolayenko VM, Schtiker LG, Batrak OA, Zavada NP, Ryabova IS, Schetinina VM

Nutrient medium was worked out on basis of acid hydrolysate of active silt for biomass cultivation Staphylococcus aureus. Nutrient medium provide enough activity increase and have low prime cost in compare with prototype.
Key words: nutrient basis, construction of mediums, cultivation

22-25

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FEATURES OF DYNAMICS OF THE INFLUENZA AND ACUTE RESPIRATORY VIRUS INFECTION OF THE GAS-DISCHARGE LAMPS PLANT
Plovetskaya IA.
The results of own researches are reported. In the Poltava Gas-Discharge Lamps Plant, the legibly expressed seasonal regularity of dynamics of the influenza + ARVI (acute respiratory virus infection) morbidity with maxima of quantity and general duration of cases in the second half of winter and minima in the second half of summer is observed. The duration of a separate case has three almost identical maxima in January, May and September. The trends of quantity of cases of influenza + ARVI diseases and general quantity of days of disease indicate existence of the legible long-term tendency to ascending of these parameters. The mean duration of one case practically does not change. Dynamics of all parameters has an the expressed periodic component, which requires further research, as well as factors conditioning it. Similar researches on other plants with some harmful working conditions are necessary for the elucidation of the role of the harmfulness of production.
Keywords: production of gas-discharge lamps, influenza and ARVI, morbidity dynamics, trend, periodicity.

25-29

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HERPES VIRAL INFECTION AND STRUCTURAL CHANGES IN WOMEN'S PLACENTA
Torianik I., Panchenko L., Kuchma I., Volyansky A., Volyansky D., Kazmirchuk V., Radchenko E., Popova N., Makarenko V
Placental preparations stained with hematoxylin-eosin and according to Van Hison were studied by histologi-cal method. Typical destructive vascular lesions with pronounced disorganization of endothelial wall, signs of stasis and thrombosis in 8 preparation of placenta were established in morphological investigations. In placental emulsions with the help of immunofermental method Herpes simplex virus of the 1-st type was detected.
 
34-37

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FEATURES IMMUNITY AT CHILDREN SICK OF THE TUBERCULOSIS AND CITOMEGALOVIRUS INFECTION
At children sick combination of infections TBC+CMV-, it is marked antigen-induced immunosupressis, caused persistentnia CMV, which the immune inflammation against itself (specific immunosupressis) and nonspecific against micobacteria tuberculosis (nonspecific immunosupressis) specifically brakes. It is necessary for taking into account at carrying out immunorehabilitation of patients with a tuberculosis.

38-42

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ANTAGONISTIC ACTIVITY PROBIOTICS IN RESPECT OF MICROORGANISM
Rizenko SA
The results of research of antagonistic action probiotics Colibacterinum, Bificol, Bifidumbacterinum, Lactobacterinum, Linex, Biosporinum and A-bacterinum on conditional pathogenics microorganisms resistance antibiotics, C.albicans and N.meningitidis are submitted. The various antagonistic activity probiotics is fixed concerning investigated microorganisms from absence her up to expressed. The marked antagonistic action probiotics it needs the further study for possibility application them in complex therapy of diseases caused resistance strains of microorganisms, and also for study epidemic strains as an epidemiological marker.
Key words:  Probiotic, antagonistic activity, resistance antibiotics

43-47

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HELICOBACTER PYLORI-HERPESVIRIDAE .
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THE ROLE OF HELICOBACTER PYLORI-HERPESVIRIDAE ASSOCIATION IN ETHYOPATHOGENESIS OF NEOPLASTIC INJURIES OF STOMACH.  MODERN ASPECTS OF STUDY
Chernyavsky VI, Birukova SV, Martynov AV, Smelyanskaya MV, Belyayevskaya SYu, Peremot SD, Krivoruchko IA, Romanova MB, Rodchenko AA, Saydametov RR.
Modern aspects of ethyological role of Helicobacter pylori and some representatives of Herpesviridae fam-ily in development of malignant tumors of stomach are reviewed. The data from literature about potential action of Helicobacter pylori during of development of MALT-lymphoma and carcinoma of stomach and relation this pathol-ogy with genetic profile of pathogenesis and his possible role in disorder of optimal relationship of the processes of proliferation and apoptosis are presented. The possible role of bacterial-viral association (Helicobacter pylori-Herpesviridae) in induction of malignant transformation of cells gastroduodenal zone and their mutual potentially influence on this process is discussed.
Key words: Helicobacter pylori, Herpesviridae, tumors of stomach, apoptos, immunological mechanisms of defense

48-65

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THE NEW CORONAVIRUS ETIOLOGIC AGENT OF ATYPICAL PNEUMONIA.
Korovayeva IV, Vovk SI, Panchenko LA.
The atypical pneumonia, which is causing by new coronavirus, has been viewed in this article. The data of etiology, epidemiology, clinic manifestation, diagnostics, treatment and prophylaxis of disease has been description.

66-74

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ASSOCIATION BETWEEN TRANSCRIPTION AND DOUBLE-STRAND BREAKS FORMATION DURING HIGH MOLECULAR WEIGHT DNA FRAGMENTATION
Kolotova T. Yu.
In this work the results of study of DNA cleavage into high molecular weight fragments in murine thymocytes and human lymphoblastoma cells (line CEM) have been summarised. It has been revealed the influence of inhibitors of RNA and protein synthesis actinomycin D and cyclogeximid on the high molecular weight DNA fragmentation. The inhibition of high molecular weight fragmentation in thymocytes by actinomycin D confirmed the supposition about the requirement of transcription for the DNA disintegration. Moreover the distribution pattern of topological domains containing c-myc between cleavable and uncleavable DNA fraction in CEM cell during and after starvation reflects the transcriptional activity of the gene.

75-83

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BIOLOGICAL PROPERTIES OF SHIGELLA SPP. ISOLATED IN SUMY REGION IN 1996-2003
Djachenko AG, Rudenko SS, Galuchko NA, Bogzko MG, Djachenko PA, Pasechnik TO.
The purpose of the study to determine the sensitivity of Shigella sonnei and Shigella flexneri to antimicrobial drugs and their clinical effectiveness for moderating recommendations for empiric therapy of shigellosis. A total of 164 strains of S.flexneri and 80 strains of S.sonnei isolated in Sumy region of Ukraine during 1996-2003 years were tested to 19 antimicrobials: ampicillin (Am), tetracyclin (Te), rifampicine (Ri), chloramphenicol (Ca), streptomycin (St), fusidin (Fu), anamycin (n), erythromycin (Er), carbenicillin (Cb), doxicyclin (Do), gentamycine (Ge), ofloxacin (Of), cefazolin (Cf), ciprofloxacin (Cp). High rate of resistance were found in both S.flexneri and S.sonnei to: Am (100%), Te (100%), Cb (90 and 50% respectively), Do (90 and 35% respectively), Fu (100%), Er (100%), Ri (100%), Ca (71,8 and 45% respectively), St (81 and 40% respectively). Some isolates were resistant to ftorchinolones.
Key words: Shigella spp., sensitivity to antibiotics

84-89

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SOME REASONS OF FORMATION INTESTINAL DYSBACTERIOSIS AT CHILDREN UNDER 3 AGE MECHNIKOV INSTITUTE OF MICROBIOLOGY AND IMMUNOLOGY OF UKRAINE MSA
Derkach SA, Nosatenko AI, Krilova IA, Strogaya EI, Davidenko MB.
The reasons of formation dysbacteriosiss formation at 160 children under 3 age were investigated. Such factors as alimentary diarrheae, colitises; allergic diseases (diathesises, dermatiteses); eating of motherly milk, physiological labor or delivery by cesarean section were taken into account. Anamnestic data and results of bacteriological examination were analyzed. It was established that at 61,1 - 88,6 % of children after delivery by cesarean section and eating of motherly milk less 25 days had significant quantitative and qualitative changes in the content of intestinal microflora. The principal disorders were: decrease of bifidum and lactobacteria (< 1x107 CFU/g); bacterial contamination; colonization of enterobacteria, pathogenic staphylococcus wither hemolytic properties, fungi of Candida genus. Intestinal dysbacteriosis was registrated more often at children with allergic diseases and with functional disorder of intestinal tract (33,3 % and 62,5 % of total number of examinated children, respectively. Such children consist the group of risk, which needs in examination of intestinal microflora to determine the complex approach to treatment and choice of optimal probiotics.
Key words: dysbacteriosis, intestinal microflora, probiotics, eubiotics, bacteriophages, sorbents.

90-99

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83-105

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