Annals of Mechnikov's Institute 2006 1
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THE EFFECTIVENESS AND ACCORDANCE OF PHYSICOCHEMICAL WAYS OF DISINFECTION OF THE WATER WITH HYGIENIC DEMANDS
Hernaya T.V.
The problem of disinfection of the water is getting more topicality because of the abrupt worsening of the ecology situation. The analysis of the information of scientific literature, which is presented in the review, characterizes modern ways of disinfection of the water with the help of chemical, physical and combined factors. The methods of disinfection are characterized from the positive way of the effectiveness of an antimicrobial action and from the negative way of different ways of processing the water.
Key words: disinfection of the water, chlorination, ozone treatment, combined methods.

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A ROLE OF LATENT, DIFFICULTLY CULTIVATED OR NON-CULTIVATED PERSISTENT BACTERIA IN HUMAN PATHOLOGY
Yelyseyeva I., Babich Ye., Volyansky Yu., Sklyar N., Bilozersky V.I.
The purpose of this literature review is a consideration of a role of bacteria L-forms in human pathology. It was presented biological characteristic of L-forms, their inductions conditions, culture properties, morphology, phases of bacterias conversion in L-forms and reversion to parent bacteria; it was shown metabolic activity of L-forms, capacity for survival during the phagocytosis and antigenic, immunogenic and sensitizing abilities. L-forms pathogenic potency were summarized according to the experimental data in vitro and in vivo, as well as clinical facts about different infectious human illnesses, autoimmune diseases and pathology with unestablished etiology. Some theoretic and practice questions about bacteria L-forms which require a further investigations are listed.
Key words: bacteria L-forms, biological properties, phagocytosis, antigenicity, immunizing capacity, etiology of diseases.
 
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LATENT INFECTION AS A RISK FACTOR FOR ATHEROSCLEROSIS FAST PROGRESSION
Krestetska S.L., Krestetsky M.G., Voliansky A.U., Koliada O.N., Kazmirchuk V.V.
A decade ago, the correction of hypercholesterolemia and hypertension was expected to prevent the fast progressing of atherosclerotic process and, in an essential measure, to warn occurrence of critical vascular events. But now, n increasing body of evidence suggests that existing conventional risk factors such as hypertension, hyperlipidaemia, diabetes mellitus and smoking account for only about 50% of atherosclerosis clinical occurrence. This fact proves expediency of new search for reliable influence factors and estimation its risks value. The infectious hypothesis proposes that various microorganisms may serve as potential etiological factors, linking inflammation and atherosclerosis (or its clinical manifestations, which now is the leading cause of critical vascular events). Evidence from seroepidemiology, molecular biology, immunology, pathology, animal models and human antibiotic intervention studies, collectively have suggested a largely positive association between infection and atherosclerosis. However, the precise nature of a causal or coincidental link between infection and atherosclerosis remains to be determined. A current perspective is presented in this review.

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SENTINEL SURVEILLANCE ON HIV-INFECTION IN PATIENTS WITH SEXUALLY TRANSMITTED DISEASES (STD). EVALUATION OF THE DISTRIBUTION
Pozdnyakov S.V., Lebedyuk M.N., Fuchigy I.S, Slavina N.G., Popova J.A., Margolin O.N.
Evaluation of the HIV-infection distribution in the population of the South region of the Ukraine (northern-west Black Sea costal region) with use of the standard information forms and results of the sentinel surveillance in group of the STDs pa-tients was done. HIV antibodies were detected in 40 samples of the 858 collected. Prevalence rate - 4,66% 0,72%, a little bit higher than obtained by the standard seromonitoring (3,740,35%). Conclusion is as follows - sentinel surveillance method allows obtain results characterizing prevalence level of the HIV-infection in the target group, which are not worth the standard seromonitoring results. For the monitoring of the situation in the target group, it will be necessary to continue investigations in the same periods
Key words: HIV-infection, HIV/AIDS, STD, infection distribution.

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SENTINEL SURVEILLANCE CONTROL ON HIV-INFECTION IN PATIENTS WITH SEXUALLY TRANSMITTED DISEASES. EVALUATION OF THE BEHAVIORAL RISK MODELS INFLUENCING HIV-INFECTION DISTRIBUTION
Pozdnyakov S.V., Lebedyuk M.N., Fuchigy I.S., Slavina N.G., Popova J.A., Margolin O.N.
Evaluation of the behavioral risk models influencing HIV-infection distribution, subjective and objective consideration to the risk group and level of the AIDS issues information were done in the frames of the sentinel surveillance control (SSC). For the processing and evaluation of the respondents anonymous polling data, personal computer program was used. It was marked ssignificant part of the STDs patients which are at the risk zone, includ-ing drug abuse. At the same time, level of the complex AIDS issues conversance is low, wile subjective opinion value added. Disbelief in possible turn for the safe behavior in 40% of polled shows potential threat of the STDs patients for the further infection distribution in the marked group and ordinary population through the sexual contacts. Use of the effective informational and educational programs for the patients with STDs is needed as well as constant SSC for the control of the situation.
Key words: AIDS, SSC, STD, risk behavior

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ANTIMICROBIAL AND ANTIFUNGAL PROPERTIES OF SUCCINYLATED β-CYCLODEXTRIN AND ITS INCLUSION COMPLEX WITH NYSTATIN
Martynov A.V., Klemchuk L.V., Osolodchenko T.P., Batrak E.A., Petrova T.M., Shtyker L.G., Zavada N.P., Lisnyak Yu.V.
In the paper, results of studies on antimicrobial and antifungal properties of succinylated β-cyclodextrin and its inclusion complex with nystatin are presented. It is shown that β-cyclodextrin does not form inclusion complex with nystatin whereas succinylated β-cyclodextrin forms opalescent inclusion complex with nystatin. Mass of the inclusion complex determined by gel-electrophoresis differs considerably from the calculated one. It may be caused by the more rigid structure of inclusion complex and correspondingly by decrease of its mobility in the gel. It is shown that succinyl β-cyclodextrin has apparent activity against P.aeruginosa, C.albicans and A.niger and strong one against S.aureus whereas in accordance with literature non-acylated β-cyclodextrin has no antimicrobial and antifungal properties. Inclusion complexes between succinyl β-cyclodextrin and nystatin were more active (by 15%-30%) compared to nystatin and β-cyclodextrin taken separately.
Key words: β-cyclodextrin, succinyl β-cyclodextrins, nystatin, inclusion complex, antimicrobial and antifungal properties

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CONTRIBUTION OF V.K. VISOKOVICH INTO DEVELOPMENT OF STUDIES ABOUT INFECTIOUS DISEASE
Pugach N.B.

In the article the author pays attention to the number of important sides of activity of genius microbiologist V.K. Visokovich; reveals fundamental principles and hypotheses of new immunity theory; investigates stages of scientific methods in creation of absolutely new type of vaccine getting from killed culture and shows mechanism of their actions against infectious disease including antrax. The author lays stress on the role of I.I. Mechnikov and V.K. Visokovich in


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