Annals of Mechnikov's Institute 2009 1
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Contents)



C. (P.)


(Editorial Board)

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(Contents)

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(REVIEWS)




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THE VAGINAL MIKROFLORA OF REPRODACTIVE AGE`S WOMEN IN THE NORM AND AT DIFFERENT PATOLOGIC PROCESSES. LITERARY REVIEW
Volkov T.A., Bolshakova G.M.
The data ofscientific literature, concerning the vaginal microflora of reproductive age women in the norm and different patalogic processes: bacterial vaginosis, clamidiosis, ureaplasmosis,  mycoplasmosis,  urogenital  candidosis   and nonspecific inflammatory processes urogenital tract.
Key words: vaginal  normal microflora, bacterial vaginosis, trichomoniasis, clamidiosis, aerobic and anaerobic microorganisms.


5-13

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(EXPERIMENTAL STUDY)



ANTIMICROBIAL  ACTIVITY  OF  SYNTHETIC  DERIVATES  OF CONDENSED HETEROCYCLIC  COMPOUNDS  WITH  PYRIDINE FRAGMENT
Evsukova V.Y., Andreieva I.D., Kazmirchuk V.V., Shulga N.M., Shcherbak O.M.,
Yuchimenko V.I..

An  experimental  study  of  the  level  and  range  of antimicrobial activity was carried out among the synthetic derivates  of  condensed  heterocyclic  compounds  with pyridine fragment. A  hign  antimicrobial  activity  of the  studied  compounds  against  gram-negative (Escherichia  coli    25922)  and  gram-positive (Staphylococcus  ureus    25923,  Bacillus anthracoides    1312)  bacteria  was  proved. The experimental data have proven the  perspectivity  of the further research of the range and level of antimicrobial activity of the compounds chosen in the course of primary screening  against  the  reference strains  pathogens  of infectious and purulent-inflammatory diseases.
Key  words:  microorganisms,  condensed heterocyclic  compounds,  antimicrobial  activity ,  infectious and purulent inflammatory diseases.

14-18

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FEATURES  OF  IMMUNE  STATUS  AT  PATIENTS  BY  ACUITY CORONAL SYNDROME UNDER HERPESVIRUS PERSISTENCE
Peremot  S.D.,  Smelyanskaya  M.V.,  Martynov  A.V.,  Peremot Y.A.
The immune status of the patients by ischemic heart diseases is characterized by deficiency of T-cells part of immune system, appearance of functionly incomplete T lymphocytes,  and  also  some  changes  of  humoral  immune  responses. The interrelation between a T-lymphopenia and fact herpesviral  persistence  for  patients  with  various  forms  of IHD is taped, that specifies formation of a set of secondary immunodeficiency symptoms, which can be regarded as result of long herpesviral persistence and exhibiting of a chronic intravascular inflammation, pathogenetical  linked with an atherosclerosis.

19-23

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F(ab`)2 FITC
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SYNTHESIS OF THE TWO-DIMENSIONAL MEMBRANES NANOSIZED ON THE THIRD COORDINATE FROM BIOLOGICALLY ACTIVE FRAGMENTS OF F (AB `) 2FITC AND THEIR BIOSENSOR PROPERTIES RESEARCH
Dzhelali V.V., Voljanskij A.J., Glazunova L.I., Martynov A.V., Osolodchenko T.P.,
Klemchuk L.V.
In the present work study a method of synthesis is of 20 layer film from anti-mice IgG sheep antibodies F (ab `) 2FITC 40 - 80 nm thick on the Pt electrode surface is proposed. At the potentials lower than - 0,250 V a cationconductance channels are opened in the obtained membrane, at the potentials higher than 0,200 V anionconductance channels are being opened. In the range between -0,250 and 0,200 V the conductance of this membrane is stochastic fluctuates. Stochastic fluctuations of conductance of membrane and current through  membrane are determined by the stochastic fluctuations of the number open of ion conductance channels. On the basis voltampere measurements it was shown that at the cathodic potentials lower than -0,250 V it carries out a function of organic ionselectiv membrane for the mice blood serum antigens. According to the hronoamperegrames taken off -0,280 V the studied interphase border Pt/nanomembrane F (ab `) 2 FITC/Nal - 0,3 M + Na24- 0,05 M is a bioelectrochemical sensor for added to the electrolyte solution mice blood serum antigens and allows selective registration of the former.
Key words: synthesis, membrane, biosensor, antigen

24-31

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  IJ  ˲˲IJ  BACILUS ALVEI
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IMMUNOMODULATION ACTION OF LIPOPOLYSACCHARIDES FROM BACILLUS ALVEI
Volaynskiy A.U.
The results of study in vitro of influence lipopolysaccharides from Bacillus alvei on functional activity macrophages and their predecessors are submitted. The immunomodulating peculiarities of lipopolysaccharides from 3 strains of Bacillus alvei have been studied. The results of researches confirm prospect of use lipopolysaccaride.. from Bacillus alvei for immunomodulation.
Key words: lipopolysaccharides from Bacillus alvei, immunomodulation, immunocompetent cells, Bacillus alvei.

32-34

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THE  HORMONAL  STATUS  OF  RATS  AT IMMUNIZATION  ON  THE  BACKGROUND  OF EXPERIMENTAL HYPOTHYROIDISM
Kuchma I.J., Simirenko L.L., Nikitchenko J.V.,bVoljanskij A.J., Tsejtlin N.A.
The features of immunogenesis hormonal regulation at rats  immunization on the background of  experimental hypothyroidism  induced  by  introduction  1-metil-2-merkaptoimidazol are studied. The dynamics of changes of  blood  whey  thyroid  hormones  concentrations  at hypothyroid  rats  in  the  course  of  formation  of  the postvaccinal humoral immune answer on ADT-anatoxin are described by empirical regression functions. 
Keywords:  thyroid  hormones,  hypothyroidism, imunization, humoral immune answer, corticosteron

35-38

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        ̲[2,1-b]Ҳ˲    òί  Ҳ    IN VITRO
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INFLUENCE OF COMPAUNDS SERIES IMIDAZO [2,1-b]TIAZOLES ON THE IMMUNE RESISTANCE INDEXES IN VITRO
Kozar V. V., Kudrya M. Y., Pavlenko T. O, Sova O.M., Yaremenko F. G.
The  influence  of  levamisole  and  its  derivative  on  the cellular,  on  the  phagocyte   link  of  immunity,  on  the leukocytes` migration faculty in the conditions in vitro has been studied. It has been revealed that the compounds are similar  in  action  towards  T-  and  B-lymphocytes, metabolic  and  phagocyte  activity  of  leucocytes.   The difference  is  that  the  levamisole  derivative  is  more efficient  in  stimulating  the  absorbent  faculty  of granulocytes,  and  levamisole   in  stimulating  migration activity of leucocytes.
Key  words:  levamisol,  levamisole  derivative,  Tlymphocytes,  B-lymphocytes,  phagocytosis,   migrantion activity of leucocytes.

39-42

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COMPARATIVE CHARACTERISTIC OF GERMS SENSITIVE EXUDED FROM DISEASED CHILDREN TO ACTION FROM COMMERCIAL SERIES BACTERIOPHAGIES MEDICINES
Derkach S.A.,Kotsar  E.V.,Voronkina .., Gabisheva L.S.,Korobkova I.V.
Comparison of study phagosense of stains exuded from different epitops from diseased children to action from commercial series of bacteriophagies medicines. It had been stated that in owerage 50-70% circulate stains were phagosensetive.
Key words: phagoterapia, bacteriophagies, phage  susceptibility.

43-47

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INFLUENCE OF LIQUID MEANS OF HYGIENE OF  AN  ORAL  CAVITY  ON  STRUCTURE  OF MICROFLORA OF A TOOTH TOUCH
Dontsova D.O., Ryabokon Y.M., Osolodchenko T.P., Shteeker L.G.
In work results of researches of specific structure of microorganisms of a tooth touch at group of students of medical university are given. Studying of influence of liquid means of hygiene of an oral cavity on change of structure  of  microflora  is  spent.  The  received  results specify  in  necessity  of  the  control  from  outside  the stomatologist of preventive application of mouthwashes.
Key words: microflora, mouthwashes, tooth touch

48-52

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DIAGNOSTIC OF THE MIXT- INFECTIONS IN AMBULATORY PATIENTS WITH THE DISORDERS OF THE UROGENITAL TRACT
Pilugin S.V., Kazmirchuk V.V., Torianik I.I.
Diagnostic of mixt-infections in the out-patients with the damage of the urogenital tract is presented in the study. It was established that at 21,8% of ambulatory patients investigated mixt- urogenital infection with a such dominated factor as a herpes simplex virus in a microbiotic assotiation. The increasing of the illness and infectiousness of ambulatory sick with the mono- and mixt herpesviral infection  may  to  determine  the  seature  of  the  biological property.  For the  increase  of  the overt favorable  longterm  treatment  effect  patients  are  needs  in  a  complex clinico-laboratory examination.
Key words:diagnostic, mixt-infections, out-patients, urogenital tract
 
53-56

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SOME MECHANISMS OF FORMOL DETOKSICATION OF TETANIC TOXIN
Kashpur N.V., Chernajvsky V. I., VolyanskyN.P., Volyansky A. Yu, Martynov A.V.
A tetanus is widely enough widespread in many countries of the world. Unflagging interest to him is explained many reasons among which main is ever-higher lethality. A vaccination is the unique effective method of warning of tetanus. A basic task is an increase of adjuvanticity of producible vaccines. Every stage of industrial receipt, cleaning and defusing of toxin is exposed to the improvement to that end. A large value has quality of nourishing environment and condition of cultivation.
Keywords: tetanus, toxin, toxoid, defusing.


57-62

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