Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ADVERSE REACTIONS TO VACCINES AND WAYS OF ITS PREVENTION Yelyseyeva I. V., Babych Ye. M., Zhdamarova L. A., Belozersky V. I., Kolpak S. A., Bobireva I. V. The overview concerns allergic reaction on vaccines and possible ways of increasing safety of immunization
on basis of use of local specific immunotherapies (SIT) experience,
particularly the sublingual route. The use of chemically altered
allergens, allergoids;alternative routes of administration, particularly the sublingual route; use of novel adjuvants, such as CpG oligonucleotides and mycobacterial vaccines; other approaches, such as allergenic peptides, relevant T-cell epitope peptide immunotherapy; DNA vaccination, recombinant and engineered allergens,
chimeric molecules and combined therapy are all approaches that have
yielded positive results to increase safety of SIT and improve its
efficacy.
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5-12 |
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| ÌÅÕÀÍÈÇÌÛ ÄËÈÒÅËÜÍÎÉ ÏÅÐÑÈÑÒÅÍÖÈÈ ÂÈÐÓÑÀ ÏÐÎÑÒÎÃÎ ÃÅÐÏÅÑÀ  ÎÐÃÀÍÈÇÌÅ ÕÎÇßÈÍÀ Äüÿ÷åíêîÏ.À., Äüÿ÷åíêî À.Ã., Êó÷ìà È.Þ., Âîëÿíñêèé À.Þ. HEUMAN HERPES SIMPLEX VIRUS MECHANISMS OF LONG TIME PERSISTENCE IN HOST ORGANISM Diachenko P.A., Diachenko A.G., Kuchma I.Yu., Volyansky A.Yu. Latency of HSV-1/2 is a complicated virus-host interaction that plays a crucial role in the
pathogenic potential of this virus. Numerous studies have indicated that sensory neurons are the primary sites of HSV latency. The ability of these viruses to reactivate from latency is responsible for recurrent disease and virus transmission. Since LAT is only known viral transcript that are abundantly transcribed in latently infected neurons, it is reasonable to hypothesize that it regulate latency. LAT protein expression is tightly regulated and may occur only at specific times during latency to prevent immune recognition. Recent studies demonstrating that the genes encoding LAT have antiapoptotic properties strongly suggest that this function plays a crucial role in promoting neuronal survival and thus latency. |
13-21 |
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| ÑÓ×ÀÑͲ ÓßÂËÅÍÍß ÙÎÄÎ ÒÀÊÑÎÍÎ̲¯ ÒÀ Á²ÎËÎò×ÍÈÕ ÎÑÎÁËÈÂÎÑÒÅÉ Ì²ÊÐÎÎÐÃÀͲÇ̲ ÏÎÐßÄÊÓ CHLAMYDIALES Ãîí÷àðåíêî Â.Â., Äæîðàºâà Ñ. Ê., Êóòîâà Â. Â. CURRENT
NOTIONS ABOUT TAXONOMY AND BIOLOGICAL PECULIARITIES OF MICROORGANISMS OF ORDER CHLAMYDIALES The
reclassification data and name species conformity of the family
Chlamydiañåàå, which was subjected most radical changes was shown in
the article. The generally accepted characteristics of the serovars
Ñ.trachomatis in according divirgences of genovar sequence for MOMP
gene (ompA) were examined. The study result of antigenic variability
ÌÎÌÐ Ñ.pneumoniae was analyzed. Common features of the microorganism
with the developmental cycle realization were shown.
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22-25 |
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| RESEARCH OF GENERAL TOXICITY OF 2Í-PIRANO[2,3-c]PYRIDINE DERIVATIVES Yevsyukova V. Y., Andreieva I. D., Kazmirchuk V. V., Scherbak O. M., Yuchimenko V. I., Lahman S. Ì., Chernyshenko D. Ì. The aim of
this study was to determine the potential general toxicity of 2Í-pyrano
[2,3-ñ] pyridines in experiments on laboratory animals (mice). The
three most promising derivatives of 2Í-pyrano[2,3-ñ]pyridines,
synthesized at Kharkov National pharmaceutical university. The study of
general toxicity of 2Í-pyrano[2,3-ñ]pyridine derivatives was carried
out on 308 outbred white mice of both sexes. According to the general
toxicity parameters the researched 2Í-pyrano[2,3-ñ]pyridine derivatives
belong to the IV class of toxicity – low toxic agents. The data
obtained in the study of general toxicity of 2Í-pyrano[2,3-ñ]pyridine
derivatives shows that the compound 1(1) – derivative of
2-imino-3-N-aricarboxamide could be acknowledged as most promising for
further studies aimed for development of antimicrobial agents based
there of.
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| EXPERIMENTAL SUBSTANTIATION OF HERB MATERIAL SELECTION IN THE MAKING OF COMPLEX TINCTURE FOR PERIODONTICS Shulga L.I., Biriucova S.V., Piminov O.F. During
this work, possibility of using of licorice roots, sedge cane
rootstocks as well as burnet rootstocks with its roots as components of
a complex tincture for periodontitis treatment was experimentally
substantiated, and an optimal raw material-extractant ratio, based on
results of microbiological studings, was proved.
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30-33 |
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| Á²ÎËÎò×Ͳ ÂËÀÑÒÈÂÎÑÒ² ÖÈÐÊÓËÞÞ×ÈÕ ² ÌÓÇÅÉÍÈÕ ØÒÀ̲ ÇÁÓÄÍÈʲ ÄÈÔÒÅв¯ ÒÀ ÊÀØËÞÊÓ Êàë³í³÷åíêî Ñ.Â., Êîëîêîëîâà Î.Á., Ðèæêîâà Ò.À., Áîëüøàêîâà Ã.Ì., Êàë³í³÷åíêî Î.Î., Ñîëîìêà Î.Î., Ïóëüíºâà Î.Ì., ϳääóáíà Ò.Ë., Êàäåðîâà À.Ã., Ñîêîëîâ À.Â., Êàñüÿíåíêî Ò.Ì., Êîòåíüîâà Ò.Î. THE BIOLOGICAL PROPERTIES OF CIRCULATING AND MUSEUM STRAINS OF DIPHTHERIA AND PERTUSSIS CAUSATIVE AGENTS Kalinichenko S.V., Kolokolova O.B., Ryzhkova T.A., Bolshakova G.M., Kalinichenko E.O., Solomka E.A., Pulneva O.N., Poddubnaya T.L., Kaderova A. G., Sokolov A.V., Kasyanenko T.N., Koteneva T.A. The article contains results of experimental studies of the most significant, in terms of bepidemiology, biological properties of Corynebacteriumand Bordetellacirculating and museum strains. It was established that all researched strains showed ability to interact with eukaryotic cells. Moreover, adhesive activity rates of pertussis causative agents were two times higher compared with the same parameters in diphtheria bacteria. All studied cultures of toxigenic corynebacteria
were able to produce neuraminidase and hyaluronidase, to inactivate
complement. However, these pathogenic properties rates depended on
Corynebacteriumbiovariant. In the study of bacteria sensitivity to
antimicrobials it was found that toxigenic corynebacteria
circulating strains were more sensitive to antibiotics, in
comparison with museum cultures. B.pertussisstrains showed resistance
to the penicillins and susceptibility to fluoroquinolones.
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33-42 |
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| ÂÏËÈ ղ̲×ÍÎ-ÌÎÄÈÔ²ÊÎÂÀÍÎÃÎ Ã˲ÊÎÏÐÎÒůÄÍÎÃÎ ÀÍÒÈÃÅÍÓ ÑÈÍÜÎÃͲÉÍί ÏÀËÈ×ÊÈ ÍÀ ÏÎÊÀÇÍÈÊÈ ²ÌÓÍÍί ÑÈÑÒÅÌÈ Ãîðîäíèöüêà Í. ²., Ìàðòèíîâ À. Â. INFLUENCE OF CHEMICALLY-MODIFIED GLICOPROTEIDIC PSEUDOMONAS AERUGINOSA ANTIGEN ON THE IMMUNITY SYSTEM Gorodnitskaya NI., Martynov AV. We have elaborated a new chemically-modified glicoproteidic Pseudomonas aeruginosa antigen for
experimental vaccination which can be used to receive vaccines and
diagnosticums against P. aeruginosa in the future. The antigen causes
the induction of high anti-Pseudomonas aeruginosa antibodies titer
(from 1: 1280 for peroral using and 1: 5120 for injection using),
activates phagocytosis, stimulates the development of delayed type of
hypersensitivity. It doesn’t influence the count of antibody-forming
cells against sheep erythrocytes.
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43-47 |
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| ÏÀÒÎËÎÃÎÌÎÐÔÎËÎò×ÍÅ ÄÎÑ˲ÄÆÅÍÍß ÂÍÓÒвØÍ²Õ ÎÐÃÀͲ ËÀÁÎÐÀÒÎÐÍÈÕ ÒÂÀÐÈÍ Ï²ÑËß ÂÂÅÄÅÍÍß ÀÍÒÈÑÅÏÒÈ×ÍÎÃÎ ÏÐÅÏÀÐÀÒÓ ÑÅÏÒÅÔÐÈË Æîðíÿê Î. ²., Ñóõëÿê Â. Â., Ïàë³é ².Ã. PATHOLOGO-MORPHOLOGICAL RESEARCH IN THE ORGANS OF LABORATORY ANIMALS AFTER INTRODUCTION PILL ANTISEPTIC SEPTEFRIL Zhornjak OI., Suchljak VV., Paly IG. In the
article it is shown the results of histological research of
pathologo-morphological changes in the organs of laboratory animals age
ðill antiseptic septefril have been shown. The given data allow us to
ascertain the absence of septefril pathological influence to
inner parenchymatous organs (liver, lungs, heart, kidneys) of
experimental animals.
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48-53 |
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| ÏÐβÄͲ ÑÈÌÏÒÎÌÈ ÒÀ ×ÀÑÒÎÒÀ ¯Õ ÂÈßÂËÅÍÍß Ó ÕÂÎÐÈÕ ÍÀ ÏÍÅÂÌÎÍ²Þ Ð²ÇÍί ÅÒ²ÎËÎò¯ Ãðàä³ëü Ã.²., Êîçüêî Â.Ì., ϳääóáíà Ò.Ë., Ìåðêóëîâà Í.Ô., Ìîãèëåíåöü Î.²., ªãîøèíà Â.Î., Àòò³êîâ Â.ª. MAIN SYMPTOMS AND FREQUENCY OF DETECTION IN PATIENTS WITH PNEUMONIA OF DIFFERENT ETIOLOGY Gradil G.I., Kozko V.N., Poddubnaja T.L., Merculova N.F., Mogilenets O.I., Egoshina V.O., Attikov V.E. Pneumonia
today occupies the first place among infectious diseases for lethality
level and occupies the 6 place for the frequency of lethal
complications in the world. Bacteriological analysis of the sputum has
revealed that the dominating causative agents of the disease are
Streptococcus pneumon³ae and Mycoplasma pneumon³ae, besides Mycoplasma
is found more frequently in younger patients. The leading symptoms of
pneumonia induced by H. influenzae, St. pneumonia, S. aureus, M.
catarrhalis were cough with sputum, crepitation, fine moist
rales. The leading symptoms in Mycoplasma-induced pneumonia were fever
and pharyngotracheobronchitis. Viral pneumonias were
characterized by fever, dry cough and also pharyngotracheobronchitis.
The means for etiological diagnosis of the bacterial and viral
pneumonias on early stages of the disease are limited due to the low
level of informativity of bacteriological methods applied for the lower
respiratory tract infections (LRTI). That fact stipulates the urgency
for additional criteria search, which could be useful for etiotropic
therapy tacticts. In connection with the mentioned above tendencies an
active search for markers that are suitable for early diagnosis of
bacterial and viral infections of LRTI is under way.
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54-59 |
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| Ç̲ÍÈ
ÏÎÏÓËßÖ²ÉÍÎÃΠвÂÍß ÁÀÊÒÅÐ²É ÊÎÐÎDzÉÍÎ ÀÊÒÈÂÍÎÃΠ̲ÊÐÎÁÍÎÃÎ ÓÃÐÓÏÎÂÀÍÍß
 ÏÐÎÖÅѲ ÔÎÐÌÓÂÀÍÍß Á²ÎÏ˲ÂÊÈ ÍÀ ÏÎÂÅÐÕͲ ÌÀËÎÂÓÃËÅÖÅÂί ÑÒÀ˲ Äåì÷åíêî Í.Ð. THE CHANGES OF THE POPULYATION LEVEL OF CORROSIVE-ACTIVE MICROBAL GROUP BACTERIA IN THE BIOFILM FORMING PROCESS ON LOW-CARBON STEEL SURFACE Demchenko N. R. The qualitative and quantitative changes of artificially created corrosive active microbal group were studied. The dynamics of quantity of sulfate-reducing bacteria, iron-reducing, denitrifying and ammonificative bacteria of corrosive microbial group during biofilm forming on low-carbon steel surface in the presence of triazoloazepinium quaternary salt with a biocie and inhibitory action were established.
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60-63 |
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| È.È. ÌÅ×ÍÈÊΠ– ÎÑÍÎÂÀÒÅËÜ ÑÎÂÐÅÌÅÍÎÉ ÌÈÊÐÎÁÈÎËÎÃÈÈ È ÈÌÌÓÍÎËÎÃÈÈ Ãàëóøêà Ð.À., Êó÷ìà È.Þ, Ãëàçóíîâà Ë.È. I.I. MECHNIKOV IS THE FOUNDER OF MODERN MICROBIOLOGY AND IMMUNOLOGY Galushkà R.A., Kuchma I.Yu, Glazunova L.I. The
article covers life, scientific work and creative activity of I.I.
Mechnikov who was a great scientist, microbiologist, immunologists and
Nobel Prize winner. His main outstanding achievements and discoveries
are mentioned.
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64-67 |
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| In memory |
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| ×ÅËÎÂÅÊ È Ó×ÅÍÛÉ (Í.Â. ÂÀÑÈËÜÅÂ) | 54-55 |
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| Review |
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| ÐÅÖÅÍÇÈß ÍÀ ÌÎÍÎÃÐÀÔÈÞ ÔÐÎËÎÂÀ À. Ô. È ÇÀÄÎÐÎÆÍÎÉ Â. È. «ÌÎËÅÊÓËßÐÍÀß ÝÏÈÄÅÌÈÎËÎÃÈß ÂÈÐÓÑÍÛÕ È ÏÐÈÎÍÍÛÕ ÈÍÔÅÊÖÈÉ» | 56-57 |
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