Annals of Mechnikov's Institute 2012 1
̲ (
Contents)



C. (P.)


(Editorial Board)

1

pdf

(Contents)

2-4

pdf

(REVIEWS)




-
.., ..

MICROBIOLOGICAL AND IMMUNOLOGICAL ASPECTS OF GUILLAIN-BARRÉ SYNDROME
Krestetska S.L., Krestetsky N.G.
Guillain-Barré syndrome (GBS) is rare postinfection monophasic autoimmune disorder, which includes different clinical  phenotypes  of  acute  immune-mediated  neuropathy.  The  symptoms  may  be  caused  by  inflammatory demyelination,  axonal  degeneration,  or  both.  Disease  pathogenesis  remains  to  be  not  clear,  despite  significant efforts in this field. Nevertheless certain progress in understanding of disease driving factors had been achieved, particularly in some points of association between the clinical phenotypes, the nature of antecedent infection and some  types  of  circulating  anti-ganglioside  antibodies.  It  was  shown  the  link  between  acute  motor  axonal neuropathy  and  antibodies  to  GM1,  GD1a,  GM1b  and  GalNAc-GD1a,  and  between  the  cranial,  bulbar  and sensory variants of GBS and antibodies to the disialylated gangliosides GQ1b, GT1a, GD1b and GD3. In addition to clinical and serological studies, the origins and measurement of antiglycolipid antibodies and their relationships to similar carbohydrate structures on infectious organisms are discussed in the context of a molecular mimicry hypothesis. Despite these advances, considerable gaps in our knowledge persist, and it is likely that other factors are involved in GBS pathogenesis. This review highlights existing level o f understanding and last updates on this topic.


5-12

pdf

Ͳ
(EXPERIMENTAL STUDY)



  - CHLAMYDIA TRACHOMATIS
..

SEMINESTED PCR FOR CHLAMYDIA TRACHOMATIS IN PATIENTS WITH UROGENITAL PATHOLOGY
Litovchenko O.A.
Investigation with seminested PCR detected Chlamydia trachomatis infection in 31,12 1,4% of patients with urogenital pathology, the highest prevalence was registered in erosion of cervix (47,05 6,05%), urethritis (33,18 2,22%), endocervicitis (32,84 2,54%).  The results were verified by amplification of additional fragment of C.trachomatis  cryptic  plasmid  with  additional  seminested  primers.  It  was  shown  that  the  developed  method exceeds test-system "AmpliSens Chlamydia trachomatis-EPh" (Russia) in sensitivity.

13-15

pdf


.., .., ..

METHODS OF STUDY AND EVALUATION OF INFLUENZA VACCINE
Volyansky A. Yu., Davydova, T.V., Kuchma I.Yu.
The  most  effective  method  of  managing  distribution  and  complications  of  infectious  diseases  is  a  vaccination. After this, for a disease that can cause epidemics and pandemics almost every year, causing great harm to human health and significant material damage, it is important to find the optimal vaccine preparation that can reliably protect  people  with  minimal  side  effects.  The  object  of  study  chosen    antipandemic  vaccine  development  and production  2009:  "Panenza"  (Sanofi  Pasteur,  France),  "MonoHryppol"  (OOO "Petrovaks"),   sub unit  substrate vaccine "MonoHryppol" (Institute of Vaccines and Serums, St. Petersburg, Russia). Were identified and analyzed using  molecular  biological  methods  of  protein  structure.  It  was  discovered  as  a  result  of  research,  the  highest among the studied immunogenicity of vaccines was observed in drug "MonoHryppol." Studying the relationship between  immunogenicity  and  protein  content  in  vaccines  revealed  its  high  value  in  the  adjuvant  vaccine "MonoHryppol"  adjuvant  which  is  "Polioksydoniy"  and   substrate.  Obviously,  the  above  can  serve  as confirmation of the assumption that this adjuvant effect of conjugated drugs on the immune response they cause, regardless of the low protein content in their composition. 

16-19

pdf

IJ Բ ί ֲ NDIDA ALBCANS STAPHYLOCOCCUS AUREUS
. .

THE COMBINED ACTION OF TERBINAFINE AND BENZOYL PEROXIDE ON THE CONSORTIUM SANDIDA ALBCANS AND STAPHYLOCOCCUS AUREUS
Lupai E.V.
Remains  an  urgent  problem  of  antibiotic  resistance  of  microorganisms  to  form  biofilms,  especially  in  mixed infections.  Strains  of  C.  albicans  and  S.  aureus  exhibit  the  ability  to  form  biofilms  in  a  more  pronounced association  of  these  microorganisms.  It  was  determined  that  the  combined  action  of  terbinafine  and benzoylperoxide effective against C. albicans and a consortium of S. aureus.



20-22

pdf

’ Բ Ͳ IJ
. .

CORRELATION BETWEEN SPECIFIC VACCINAL AND SYSTEMIC IMMUNITY OF
IMMUNOCOMPROMISED CHILDREN
Volyanskiy A.Yu.
Dependence of specific vaccinal immunity level from some indexes of common immunity of the children with often acute respiratory diseases was discovered. Combination low absorbing and biocidic activity of leukocytes, lowering of lymphocyte ability for proliferation and weak secretory potential of blood mononuclears for IL-21, IL-15, IL-2 prevent from the formation of strained and long vaccinal immunity of examinated children category.


23-29

pdf

˲ ֲ ֲ
. ., . .

APOPTOSIS OF PHAGOCYTE CELLS IN BCG VACCINATION AND  REVACCINATIONS
Ilyinskaya I.F., Zubriychuk O.M.
The special apoptosis features of phagocytic cells were studed in 40 Balb/c line mouse, who were BCGvaccinated for one-, binary- and three times. On the 30th day after the last dose of vaccine the content of apoptic neutrophils in the peripheral blood was determined, the intensity of spontaneous apoptosis of b lood neutrophils and peritoneal macrophages, the effect of autologic serum on apoptosis of blood neutrophils and peritoneal macrophages, the bacterial load of macrophages by native and opsonized mycobacteria and apoptosis of macrophages induced by native and opsonized mycobacteria were detected. It was found that increase of the BCG-vaccination multiplicity caused a more severe bacterial load of phagocytes and intencification of their programmed cell death that did not lead to a decrease f these cells number, promoted the formation of long-term mycobacterial persistence and the maintenance of post-vaccination immunity.

30-36

pdf

ֲ IJ ²IJ ̲ ̲ Ҳ ̲Ͳ -  Ͳ- Ѳ
.., ̳ .., .., ̳ .., ..

EVALUATION OF RADIATION AND LED RESISTANCE AT MICROORGANISMS, AGENTS INFLAMMATORY PROCESSES
Tsyganenko A.J., Mishina M.., Dubovik .S., Mishin Y.M., Glazunov A.V.
The estimation of the impact of LED blue and red radiation with chemotherapeutic agents in isolates of pathogens of purulent-inflammatory processes.  Found that the  isolates  belonged to the  chemotherapy  is variable  under the influence of drug exposure LEDs: a blue light contributed to increased antibiotic susceptibility of isolates, and the red light, in most cases did not affect antibiotic susceptibility.


37-41

pdf

        .
.., ..

THE MODERN MANIFESTATION OF PARENTERAL HEPATITISES EPIDEMIC PROCESS IN DZERJHYNSKY DISTRICT OF KHARKIV
Serduk V.V., Nevmerzhitskaya S.H.
The assessment of parenteral hepatitises dissemination and the epidemic process manifestation in the one of the biggest districts of Kharkiv is given in the article

42-46

pdf

˲ ˲ ò
.., .., ..

THE PROPERTIES OF CARRAGEENAN GELS
Grubnik I.M., Gladukh Ye.V., Chernyaev S.V.

The  article  presents  the  results  of  studies  on  the  functional  properties  of  carrageenan,  depending  on  the concentration of sodium chloride and xanthan in gels. It is established that the main factors in the syneresis of carrageenan gels are its concentration, the presence of ions and gums in solution. If using sodium chloride there is a change in the structure of mesh of the resulting gel, which leads to an increase in syneresis.

47-50

pdf


(Short articles)




.., .., .., .., ..

MODERN ASPECTS OF PROPHYLAXIS AND TREATMENT OF INFLUENZA
Divocha V.A., Lagoda O.V., Russu A.V., Michalchuk V.N., Gozenko A.I.

51-52

pdf

ջ
.., .., .., .., ..

DETERMINATION OF ETIOLOGICAL MICROORGANISMS ASSOCIATION IN BACTERIAL PYELONEPHRITIS
Mishin V.V., Gritcenko L.Z., Shipov D.O., Troyan N.S., Lazurenko E.E.

52-53

pdf


(Informational letter)



ֲ ²
.., .., .., .., .. , Գ ..

PROBLEM CHILD INFECTIONS IN MILITARY CONSCRIPTS FORCES UKRAINE
Cojocaru AA, Zemtsov AM, Yakymets VM, G. Meadow, Ivanko AM , Filippenko LI

54-55

pdf



(Methodology)





ֲ IJ, ʲ в, ϲ Ҳ
Newsletter
TACTICS immunization of children, who often get sick, and means to enhance its effectiveness

56-57

pdf


In Memory



..
58

pdf