Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÌÈÊÐÎÁÈÎËÎÃÈ×ÅÑÊÈÅ È ÈÌÌÓÍÎËÎÃÈ×ÅÑÊÈÅ ÀÑÏÅÊÒÛ ÑÈÍÄÐÎÌÀ ÃÈÉÅÍÀ-ÁÀÐÅ Êðåñòåöêàÿ Ñ.Ë., Êðåñòåöêèé Í.Ã. MICROBIOLOGICAL AND IMMUNOLOGICAL ASPECTS OF GUILLAIN-BARRÉ SYNDROME Krestetska S.L., Krestetsky N.G. Guillain-Barré
syndrome (GBS) is rare postinfection monophasic autoimmune disorder,
which includes different clinical phenotypes of
acute
immune-mediated neuropathy. The symptoms
may be caused by inflammatory
demyelination, axonal degeneration, or
both. Disease pathogenesis remains to
be not clear, despite significant efforts in
this field. Nevertheless certain progress in understanding of disease
driving factors had been achieved, particularly in some points of
association between the clinical phenotypes, the nature of antecedent
infection and some types of circulating
anti-ganglioside antibodies. It was shown
the link between acute motor axonal
neuropathy and antibodies to GM1,
GD1a, GM1b and GalNAc-GD1a, and
between the cranial, bulbar and sensory
variants of GBS and antibodies to the disialylated gangliosides GQ1b,
GT1a, GD1b and GD3. In addition to clinical and serological studies,
the origins and measurement of antiglycolipid antibodies and their
relationships to similar carbohydrate structures on infectious
organisms are discussed in the context of a molecular mimicry
hypothesis. Despite these advances, considerable gaps in our knowledge
persist, and it is likely that other factors are involved in GBS
pathogenesis. This review highlights existing level o f understanding
and last updates on this topic.
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5-12 |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| ÀÍÀËÈÇ ÐÅÇÓËÜÒÀÒΠÏÐÈÌÅÍÅÍÈß ÏÎËÓÃÍÅÇÄÍÎÃÎ ÌÅÒÎÄÀ ÏÖÐ-ÄÈÀÃÍÎÑÒÈÊÈ CHLAMYDIA TRACHOMATIS Ëèòîâ÷åíêî Î.À. SEMINESTED PCR FOR CHLAMYDIA TRACHOMATIS IN PATIENTS WITH UROGENITAL PATHOLOGY Litovchenko O.A. Investigation
with seminested PCR detected Chlamydia trachomatis infection in 31,12 ±
1,4% of patients with urogenital pathology, the highest prevalence was
registered in erosion of cervix (47,05 ± 6,05%), urethritis (33,18 ±
2,22%), endocervicitis (32,84 ± 2,54%). The results were verified
by amplification of additional fragment of C.trachomatis
cryptic plasmid with
additional seminested primers. It was
shown that the developed method exceeds
test-system "AmpliSens Chlamydia trachomatis-EPh" (Russia) in
sensitivity.
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13-15 |
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| ÌÅÒÎÄÛ ÈÇÓ×ÅÍÈß È ÎÖÅÍÊÈ ÃÐÈÏÏÎÇÍÛÕ ÂÀÊÖÈÍ Âîëÿíñêèé À.Þ., Äàâûäîâà Ò.Â., Êó÷ìà È.Þ. METHODS OF STUDY AND EVALUATION OF INFLUENZA VACCINE Volyansky A. Yu., Davydova, T.V., Kuchma I.Yu. The
most effective method of
managing distribution and complications
of infectious diseases is a vaccination.
After this, for a disease that can cause epidemics and pandemics almost
every year, causing great harm to human health and significant material
damage, it is important to find the optimal vaccine preparation that
can reliably protect people with minimal
side
effects. The object of study
chosen antipandemic vaccine
development and production 2009: "Panenza"
(Sanofi
Pasteur, France), "MonoHryppol" (OOO
"Petrovaks"), sub unit substrate vaccine
"MonoHryppol" (Institute of Vaccines and Serums, St. Petersburg,
Russia). Were identified and analyzed using molecular
biological methods of
protein structure. It was discovered
as a result of research, the
highest among the studied immunogenicity of vaccines was observed in
drug "MonoHryppol." Studying the relationship between
immunogenicity and protein
content in vaccines revealed its
high value in the adjuvant vaccine
"MonoHryppol" adjuvant which is
"Polioksydoniy" and substrate. Obviously,
the above can serve as confirmation of the
assumption that this adjuvant effect of conjugated drugs on the immune
response they cause, regardless of the low protein content in their
composition.
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16-19 |
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| ÊÎÌÁ²ÍÎÂÀÍÀ Ä²ß ÒÅÐÁ²ÍÀÔ²ÍÓ ÒÀ ÁÅÍÇίËÏÅÐÎÊÑÈÄÓ ÍÀ ÊÎÍÑÎÐÖ²ÓÌ ÑÀNDIDA ALB²CANS ² STAPHYLOCOCCUS AUREUS Ëóïàé Î. Â. THE COMBINED ACTION OF TERBINAFINE AND BENZOYL PEROXIDE ON THE CONSORTIUM SANDIDA ALB²CANS AND STAPHYLOCOCCUS AUREUS Lupai E.V. Remains
an urgent problem of
antibiotic resistance of microorganisms
to form biofilms, especially in mixed
infections. Strains of C. albicans
and S. aureus exhibit the ability
to form biofilms in a more
pronounced association of these microorganisms.
It
was determined that the combined
action of terbinafine and benzoylperoxide effective
against C. albicans and a consortium of S. aureus.
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| ÂÇÀªÌÎÇÂ’ßÇÎÊ ÑÏÅÖÈÔ²×ÍÎÃÎ ÂÀÊÖÈÍÀËÜÍÎÃÎ ÒÀ ÑÈÑÒÅÌÍÎÃÎ ²ÌÓͲÒÅÒÓ ²ÌÓÍÎÊÎÌÏÐÎÌÅÒÎÂÀÍÈÕ Ä²ÒÅÉ Âîëÿíñüêèé À. Þ. CORRELATION BETWEEN SPECIFIC VACCINAL AND SYSTEMIC IMMUNITY OF IMMUNOCOMPROMISED CHILDREN Volyanskiy A.Yu. Dependence
of specific vaccinal immunity level from some indexes of common
immunity of the children with often acute respiratory diseases was
discovered. Combination low absorbing and biocidic activity of
leukocytes, lowering of lymphocyte ability for proliferation and weak
secretory potential of blood mononuclears for IL-21, IL-15, IL-2
prevent from the formation of strained and long vaccinal immunity of
examinated children category.
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23-29 |
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| ÀÏÎÏÒÎÇ ÔÀÃÎÖÈÒÓÞ×ÈÕ Ê˲ÒÈÍ ÏÐÈ ÂÀÊÖÈÍÀÖ²¯ ÒÀ ÐÅÂÀÊÖÈÍÀÖ²¯ ÁÖÆ ²ëü¿íñüêà ². Ô., Çóáð³é÷óê Î. Ì. APOPTOSIS OF PHAGOCYTE CELLS IN BCG VACCINATION AND REVACCINATIONS Ilyinskaya I.F., Zubriychuk O.M. The
special apoptosis features of phagocytic cells were studed in 40
Balb/c line mouse, who were BCGvaccinated for one-, binary- and three
times. On the 30th day after the last dose of vaccine the content of
apoptic neutrophils in the peripheral blood was determined, the
intensity of spontaneous apoptosis of b lood neutrophils and peritoneal
macrophages, the effect of autologic serum on apoptosis of blood
neutrophils and peritoneal macrophages, the bacterial load of
macrophages by native and opsonized mycobacteria and apoptosis of
macrophages induced by native and opsonized mycobacteria were detected.
It was found that increase of the BCG-vaccination multiplicity caused a
more severe bacterial load of phagocytes and intencification of their
programmed cell death that did not lead to a decrease îf these cells
number, promoted the formation of long-term mycobacterial persistence
and the maintenance of post-vaccination immunity.
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30-36 |
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| ÎÖ²ÍÊÀ
IJ¯ ѲÒËÎIJÎÄÍÎÃÎ ÂÈÏÐÎ̲ÍÞÂÀÍÍß ² ÏÐÎÒÈ̲ÊÐÎÁÍÈÕ ÏÐÅÏÀÐÀҲ ÍÀ
̲ÊÐÎÎÐÃÀͲÇÌÈ - ÇÁÓÄÍÈÊÈ ÃͲÉÍÎ-ÇÀÏÀËÜÍÈÕ ÏÐÎÖÅѲ Öèãàíåíêî À.ß., ̳øèíà Ì.Ì., Äóáîâèê Î.Ñ., ̳øèí Þ.Ì., Ãëàçóíîâ À.Â. EVALUATION OF RADIATION AND LED RESISTANCE AT MICROORGANISMS, AGENTS INFLAMMATORY PROCESSES Tsyganenko A.J., Mishina M.Ì., Dubovik Å.S., Mishin Y.M., Glazunov A.V. The
estimation of the impact of LED blue and red radiation with
chemotherapeutic agents in isolates of pathogens of
purulent-inflammatory processes. Found that the
isolates belonged to the chemotherapy is
variable under the influence of drug exposure LEDs: a blue light
contributed to increased antibiotic susceptibility of isolates, and the
red light, in most cases did not affect antibiotic susceptibility.
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37-41 |
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| ÏÐÎßÂËÅÍÈß
ÝÏÈÄÅÌÈ×ÅÑÊÎÃÎ ÏÐÎÖÅÑÑÀ ÏÀÐÅÍÒÅÐÀËÜÍÛÕ ÃÅÏÀÒÈÒΠÍÀ
ÒÅÐÐÈÒÎÐÈÈ ÄÇÅÐÆÈÍÑÊÎÃÎ ÐÀÉÎÍÀ ã. ÕÀÐÜÊÎÂÀ Ñåðäþê Â.Â., Íåâìåðæèöêàÿ Ñ.Õ. THE MODERN MANIFESTATION OF PARENTERAL HEPATITISES EPIDEMIC PROCESS IN DZERJHYNSKY DISTRICT OF KHARKIV Serduk V.V., Nevmerzhitskaya S.H. The assessment of
parenteral hepatitises dissemination and the epidemic process
manifestation in the one of the biggest districts of Kharkiv is given
in the article
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42-46 |
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| ÄÎÑ˲ÄÆÅÍÍß ÂËÀÑÒÈÂÎÑÒÅÉ ÃÅ˲ ÊÀÐÀòÍÀÍÓ Ãðóáíèê ².Ì., Ãëàäóõ ª.Â., ×åðíÿºâ Ñ.Â. THE PROPERTIES OF CARRAGEENAN GELS Grubnik I.M., Gladukh Ye.V., Chernyaev S.V. The
article presents the results of
studies on the functional properties
of carrageenan, depending on the concentration
of sodium chloride and xanthan in gels. It is established that the main
factors in the syneresis of carrageenan gels are its concentration, the
presence of ions and gums in solution. If using sodium chloride there
is a change in the structure of mesh of the resulting gel, which leads
to an increase in syneresis.
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47-50 |
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| Êîðîòê³ ïîâ³äîìëåííÿ (Short articles) |
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| ÑÎÂÐÅÌÅÍÍÛÅ ÀÑÏÅÊÒÛ ÏÐÎÔÈËÀÊÒÈÊÈ È ËÅ×ÅÍÈß ÃÐÈÏÏÀ Äèâî÷à Â.À., Ëàãîäà Î.Â., Ðóññó À.Â., Ìèõàëü÷óê Â.Í., Ãîæåíêî À.È. MODERN ASPECTS OF PROPHYLAXIS AND TREATMENT OF INFLUENZA Divocha V.A., Lagoda O.V., Russu A.V., Michalchuk V.N., Gozenko A.I. |
51-52 |
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| ÎÏÐÅÄÅËÅÍÈÅ «ÝÒÈÎËÎÃÈ×ÅÑÊÈÕ» ÀÑÑÎÖÈÀÖÈÉ ÌÈÊÐÎÐÃÀÍÈÇÌΠÏÐÈ ÁÀÊÒÅÐÈÀËÜÍÛÕ ÏÈÅËÎÍÅÔÐÈÒÀÕ Ìèøèí Â.Â., Ãðèöåíêî Ë.Ç., Øèïîâ Ä.Î., Òðîÿí Í.Ñ., Ëàçóðåíêî Å.Å. DETERMINATION OF ETIOLOGICAL MICROORGANISM’S ASSOCIATION IN BACTERIAL PYELONEPHRITIS Mishin V.V., Gritcenko L.Z., Shipov D.O., Troyan N.S., Lazurenko E.E. |
52-53 |
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| ²íôîðìàö³éíèé ëèñò (Informational letter) |
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| ÏÐÎÁËÅÌÀ ÄÈÒß×ÈÕ ²ÍÔÅÊÖ²É Ó Â²ÉÑÜÊÎÂÈÕ ÊÎËÅÊÒÈÂÀÕ ÇÑ ÓÊÐÀ¯ÍÈ Êîæîêàðó À.À., Çåìöîâ Î.Ì., ßêèìåöü Â.Ì., Ëóãîâà Ã.Â., ²âàíüêî Î.Ì. , Ô³ë³ïåíêî Ë.². PROBLEM CHILD INFECTIONS IN MILITARY CONSCRIPTS FORCES UKRAINE Cojocaru AA, Zemtsov AM, Yakymets VM, G. Meadow, Ivanko AM , Filippenko LI |
54-55 |
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Ìåòîäè÷í³ ðåêîìåíäàö³¿ (Methodology) |
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ÒÀÊÒÈÊÀ ÂÀÊÖÈÍÀÖ²¯ IJÒÅÉ, ßʲ ×ÀÑÒÎ ÕÂÎвÞÒÜ, ÒÀ ÇÀÑÎÁÈ Ï²ÄÂÈÙÅÍÍß ¯¯ ÅÔÅÊÒÈÂÍÎÑÒ² Newsletter TACTICS immunization of children, who often get sick, and means to enhance its effectiveness |
56-57 |
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In Memory |
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| ÏÀÌßÒÈ Ó×ÅÍÎÃÎ È ÏÅÄÀÃÎÃÀ Ë.À. ÁÎÍÄÀÐÅÍÊÎ ÏÎÑÂßÙÀÅÒÑß |
58 |
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