Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-5 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÑÓ×ÀÑͲ ÀÑÏÅÊÒÈ ÅÒ²ÎËÎò¯, ÏÀÒÎÃÅÍÅÇÓ ÒÀ
Ê˲Ͳ×ÍÈÕ ÏÐÎß² ϲÎÄÅÐÌ²É (ÎÃËßÄ Ë²ÒÅÐÀÒÓÐÈ) Ïèëþã³í Ñ.Ì. THE MODERN ASPECTS OF ETIOLOGY, PATHOGENESIS AND CLINICAL PRESENTATIONS OF PYODERMA (LITERARY REVIEW) Pilugin S.M. The necessity of
study of pyogenic skin infection is presented in the article. The
modern aspects of etiology, pathogenesis and clinical presentations of
different forms of pyoderma (deep and superficial) are described.
Keywords:
pyoderma, etiology, pathogenesis, clinical presentations. |
6-11 |
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| ÀϲÒÅÐÀÏÅÂÒÈ×Ͳ ÇÀÑÎÁÈ: ÐÎÇÐÎÁÊÈ ²
ÏÅÐÑÏÅÊÒÈÂÈ ¯Õ ÂÈÊÎÐÈÑÒÀÍÍß Â ²ÍÔÅÊÖ²ÉÍ²É ÏÀÒÎËÎò¯ ËÞÄÈÍÈ (ÎÃËßÄ Ë²ÒÅÐÀÒÓÐÈ) Ðàä÷åíêî Î. Î. APITHERAPEUTICAL FUNDS: NEW DEVELOPMENT AND PROSPECTS OF INFECTIOUS DISEASES IN PERSON (REVIEW) Radchenko E. A. The analysis of
the development, the study of antimicrobial properties of
pharmacological agents that are based on phenolic propolis and
hydrophilic drug shows promise for the use of complex treatment of
infectious diseases.
Keywords:
phenolic hydrophilic drug propolis anticoronavirus activity,
antibacterial, apipreparats, actoprotective properties. |
12-16 |
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| ÍÅÉÐÎÂÀÊÖÈÍÀ ÏÐÈ ÑÛÏÍÎÌ ÒÈÔÅ Â ÒÐÓÄÀÕ Ì. Ì.
ÖÅÕÍÎÂÈÖÅÐÀ (ÎÁÇÎÐ ËÈÒÅÐÀÒÓÐÛ) Ìîèñååíêî Ò.Í. NEUROVACINIA WITH TYPHUS IN THE WORKS OF Ì. Ì. TZEKHOWITZER (REVIEW) Moiseyenko T.N. The article
describes the work priorities M. M. Tzekhnowitzer. Describes the
production of various types neurovaccinia. Characterized by
immunization of animals living typhous neyrovirusom. The efficiency
formalized and karbolizovannoy neurovaccinia in experiments on guinea
pigs and human volunteers. Considered theoretically important works M.
M. Tzekhnowitzer in modern vaccine.
Keywords:
neyrovirus, titrazh, subinfection dose, injection, typhus, vaccine,
immunity. |
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ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ |
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| FEATURES OF ETIOLOGIC SPECTRUM OF ACUTE
ALLERGY, URTICARIA FOR CHILDREN DEPENDING ON SEX AND AGE BY NOMOGRAPHIC METHOD Shmulich V.Ê., Prohorenko A.À., Ishenko T.B., Uryvaeva Ì.Ê., Samsonenko V.I., Dzikevich L.A., Shmulich Î.V., Staruseva V.V., Aschelov A.Ì., Reunova N.Ì., Zaporogets ².A. In this work
there are presented the results of allergy testings of 186 children
suffering from acute allergy, urticaria. The aim of this study was the
specification of casually significant allergen depending on sex and
age. Results of testing are processed by a method of the mathematiical
analysis, raised in nomograms according to which, considering the
nosological entity of disease, sex and age of a patient, it`s defined
causally significant allergen.
Keywords:
nomographic method, children, etiology, acute allergy, urticaria,
scarification
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21-26 |
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| ÀÍÒÈÁÀÊÒÅвÀËÜͲ ÂËÀÑÒÈÂÎÑÒ² ÔÀÐÌÀÖÅÂÒÈ×Íί
ÊÎÌÏÎÇÈÖ²¯ ÎÐͲÄÀÇÎËÓ Ç
ÔËÀ̲ÍÎÌ Áîáðèöüêà Ë. Î., Ðóáàí Î. À., Îñîëîä÷åíêî Ò. Ï., Ùåðáàê Î. Ì., Äìèòð³ºâñüêèé Ä. ². ANTIBACTERIAL PROPERTIES OF PHARMACEUTICAL COMPOSITIONS WITH ORNIDAZOLE AND FLAMIN Bobritskaya L.A., Ruban H.À., Osolodchenko T.P.,Shcherbak O.N., Dmitrievskiy D.I. For the treatment
of protozoal-associated bacterial infections of a pharmaceutical
composition in capsule form, which includes ornidazole and herbal
substances flamini. Established antimicrobial activity against
anaerobic (Clostridium perfringens 28, Clostridium noyvi 277,
Peptococcus niger, Bacteroides fragilis 13/83) and aerobic
(Staphylococcus aureus ATCC 26923, Escherichia coli ATCC 25922,
Bañillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 27853)
bacteria and fungi (Candida albicans ATCC 653/885).
Keywords :
antibacterials preparations, capsule, ornidazole, flamini. |
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| ÈÑÏÎËÜÇÎÂÀÍÈÅ ÏÎËÈÌÅÐÀÇÍÎÉ ÖÅÏÍÎÉ ÐÅÀÊÖÈÈ
ÏÐÈ ÈÇÓ×ÅÍÈÈ ÌÓÇÅÉÍÛÕ ØÒÀÌÌÎÂ
CORYNEBACTERIUM DIPHTHERIAE, ÖÈÐÊÓËÈÐÎÂÀÂØÈÕ ÍÀ ÒÅÐÐÈÒÎÐÈÈ ÓÊÐÀÈÍÛ Â 60-Å ÃÎÄÛ ÕÕ ÂÅÊÀ Ìèðîíåíêî Ë.Ã., Äîàí Ñ.È., Ñàâ÷óê À.È. POLYMERASE CHAIN REACTION USAGE IN STUDYING OF C. DIPHTHERIAE MUSEUM STRAINS, WHICH WERE ISOLATED IN UKRAINE IN 60 YEARS OF XX CENTURY Myronenko L.G., Doan S.I., Savchuk A.I. The 22 C.
diphtheriae museum strains were studied by polymerase chain reaction
with specific primers on tox-gene and arbitrary primer ¹ 45. These
strains were isolated in 1961 in Gorlovka of Donetsk region and in 1963
in Kharkov. The certificates of these museum strains were specified and
supplemented due to this investigation. The half of these studied
strains were genetic similar and belong to single PCR-type. Besides
that, three genetic isolated types were circulating in the East region
of Ukraine in this and latest periods.
Keywords:
C. diphtheriae, polymerase chain reaction with specific and arbitrary
primers. |
32-39 |
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| ÂÈÂ×ÅÍÍß ÂÏËÈÂÓ ÏÅÐÎÐÀËÜÍÎÃÎ ÂÂÅÄÅÍÍß
ÀÍÒÈÃÅÍÍÈÕ ÏÐÅÏÀÐÀҲ ÇÁÓÄÍÈÊÀ ÄÈÔÒÅв¯ ÍÀ ÐÎÇÂÈÒÎÊ ØʲÐÍί ÐÅÀÊÖ²¯ Ó ÊÐÎ˲ Áàáè÷ ª. Ì,, ªëèñåºâà ². Â., Æäàìàðîâà Ë. À., Á³ëîçåðñüêèé Â. ²., Áîáèðºâà ². Â. STUDY OF INFLUENCE OF PREVIOUS ORAL APPLICATION OF DIPHTHERIA ANTIGENIC PREPARATIONS ON RABBIT ALLERGIC REACTION FORMING AFTER SKIN TEST Babych Ye. M., Yelyseyeva I. V., Zhdamarova L. A., Belozersky V. I. , Bobireva I. V. It’s studied an
influence of previous oral application of diphtheria antigenic
preparations on allergic inflammation forming after skin test. It’s
used destroyed by ultrasonic microbe cells C.diphtheriae var. gravis
tox+ massachusets, free from destroyed cells by the use of
centrifugation supernatant and refined concentrated diphteria toxoid.
Experimental rabbits are fed to 3,5 ml of one of antigenic preparations
(the total protein dose is 33,6 mg), control ones are fed to saline. In
a week all animals were injected intracutaneously 0,2 ml each of
corresponding antigenic preparation. The findings testify to decreasing
manifestation tendency of rabbit skin reactions on antigenic
preparations.
Keywords:
diphtheria pathogen, antigenic preparations, oral imunization, skin
allergic reaction |
40-43 |
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| ÐÎËÜ ÌÎÍÎÖÈÒÀÐÍÎ-ÔÀÃÎÖÈÒÀÐÍÎÉ ÑÈÑÒÅÌÛ Â
ÔÎÐÌÈÐÎÂÀÍÈÈ ÏÐÎÒÈÂÎÂÈÐÓÑÍÎÉ ÐÅÇÈÑÒÅÍÒÍÎÑÒÈ Ó ÌÛØÅÉ ÏÎÑËÅ ÏÐÅÄÂÀÐÈÒÅËÜÍÎÃÎ ÂÂÅÄÅÍÈß ÊÐÈÎÊÎÍÑÅÐÂÈÐÎÂÀÍÍÎÉ ÊÎÐÄÎÂÎÉ ÊÐÎÂÈ Êîæèíà Î. Þ., Îñòàíêîâà Ë. Â., Îñòàíêîâ Ì. Â., Áîíäàðîâè÷ Í. À., Ãîëüöåâ À. Í. ROLE OF MONOCYTE PHAGOCYTIC SYSTEM IN FORMATION OF ANTIVIRAL RESISTANCE IN MICE AFTER PRELIMINARY INJECTION OF CRYOPRESERVED CORD BLOOD Kozhina O.Yu., Ostankova L.V., Ostankov M.V, Bondarovich N.A., Goltsev A.N. Now the task of
preventive maintenance and search of biologically active substances,
capable to make active the nonspecific immune response, remains an
actual during flu epidemic. It has been previously established, that
cryopreserved leucoconcentrate of human cord blood (cLHCB) can act as
modulator of activity of immunity. In the given work there was
estimated influence of preventive injection of cLHCB and its components
on functional activity of monocyte phagocytic system cells (MPSC) in
mice in the conditions of the induced influenzal infection. Preliminary
introduction of cLHCB and its components 6 months prior to infection by
flu virus makes 2 times increase of functional activity of macrophages,
preventing inhibition of a nonspecific link of immunity. Thus, cLHCB
inhibit of secondary immune deficiency development. The found increase
in phagocytic activity of peritoneal cavity cells and 3 times
increasesing of CD11b-marker expression after preventive injection of
cLHCB testifies to rise of adherence and protective potential of MPSC
that is one of possible mechanisms of formation of resistance to a flu
virus. It is shown, that intranasal cLHCB injection before development
of viral infection it can be recommended as the method of preventive
maintenance of flu.
Keywords:
cryopreserved cord blood, monocyte phagocytic system, flu preventive
maintenance. |
44-51 |
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| ÇÍÀ×ÅÍÈÅ ÑÎÄÅÐÆÀÍÈß ÍÅÊÎÒÎÐÛÕ ÈÍÒÅÐËÅÉÊÈÍÎÂ
ÑÛÂÎÐÎÒÊÈ ÊÐÎÂÈ Â ÎÏÐÅÄÅËÅÍÈÈ ÒßÆÅÑÒÈ ÒÅ×ÅÍÈß
ÕÐÎÍÈ×ÅÑÊÎÃÎ ËÀÐÈÍÃÈÒÀ Ó ËÈÖ Ñ ÏÅÐÑÈÑÒÈÐÓÞÙÅÉ ÃÅÐÏÅÑÂÈÐÓÑÍÎÉ
ÈÍÔÅÊÖÈÅÉ (ÂÏÃ 1,2ÒÈÏ) Ãàðþê Ã.È., Êóëèêîâà Å.À., Çóåòèð Ñàìèð CYTOKINES AND C-REACTIVE PROTEIN CONTENT IN SERUM BLOOD OF PATIENTS WITH CHRONIC LARYNGITIS DISEASE Garyuk G. I., Kulikova E.A., Zaiter Samir Some kinds of
interleikines of patients with chronic laryngitis disease were
investigated. There is “cytokines explosion” of the patients with
chronic laryngitis with persistent herpes simplex virus. Comparative
investigation cytokine profile in serum blood is demonstrated: balanced
reaction cytokines profile of patients with chronic laryngitis without
persistent herpes simplex virus and dysbalanced reaction of patients
with laryngitis (hyperergation). Increased content IL-6 and low content
g-interferon and tumor necrosis factor (TNF-a) are predisposition of
chronisation inflammation processes in larynges. This situation needs
sighting correction.
Keywords:
herpes simplex virus, cytokines, ñhronic laryngitis disease. |
49-53 |
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| ÎÑÎÁÅÍÍÎÑÒÈ ÃÎÐÌÎÍÀËÜÍÎÃÎ ÔÎÍÀ ÏÐÈ ÎÑÒÐÎÌ
ÀËËÅÐÃÎÇÅ, ÊÐÀÏÈÂÍÈÖÅ Ó ÄÅÒÅÉ Øìóëè÷ Î.Â. , Ìÿñîåäîâ Â.Â. ESPECIALLY HORMONAL ACUTE ALLERGIES, URTICARIA IN CHILDREN Shmulic O.V. , Myasoedov V.V. In the work the
results of research TSH, T3, T4, cortisol levels in children with acute
allergies, urticaria. Significantly increased TSH in the absence of
changes in the concentrations of T3, T4, cortisol, which is the
rationale for the use of synthetic corticosteroids in the treatment of
acute allergosis, urticaria.
Keywords:
acute allergosis, urticaria, children, kartizol, T3, T4, TSH. |
54-56 |
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| ËÀÁÎÐÀÒÎÐÍÀ ÌÎÄÅËÜ ÕÐÎͲ×ÍÎÃÎ
ÑÒÀÔ²ËÎÊÎÊÎÂÎÃÎ ÒÎÍÇÈ˲ÒÓ Ñêëÿð Í.²., Êàë³í³÷åíêî Ñ.Â., Ðèæêîâà Ò.À., Áàáè÷ ª.Ì., Æóðàâëüîâ À.Ñ., Ìàí³ Õàíñ, Æäàìàðîâà Ë.À, Øêîäîâñüêà Í.Þ., Áàëàê Î.Ê. LABORATORY MODEL OF CHRONIC STAPHYLOCOCCAL TONSILLITIS Sklyar N.I., Kalinichenko S.V., Ryzhkova T.A., Babych E.M., Zhyravlev A.S., Mani Hans, Zhdamarova L.A., Shkodovska N.Yu., Balak A.K. Investigation and
development of new preparations for chronic tonsillitis (CT) treatment
and prevention requires application of appropriate laboratory model.
For the development of CT laboratory model chronic pyoinflammatory
process was reproduced in chinchilla rabbits using Staphylococcus
aureus 209 Ð (ÀÒÑÑ 6538-Ð) reference-strain. Preliminary sensitizing of
animals with inactivated causative agent and repeated infection with
the reference-strain made it possible to work out reproducible model of
chronic tonsillitis. Adequacy of chronic tonsillitis development was
confirmed by the results of microbiological and pathomorphological
researchers. The proposed laboratory model can be used for solving of
theoretical and practical medicine and pharmacology topical problems.
Keywords:
laboratory model, staphylococcus, chronic tonsillitis. |
57-60 |
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| ÆÈÒÒªÇÄÀÒͲÑÒÜ ÒÀ
ÀÄÃÅÇÈÂͲ ÂËÀÑÒÈÂÎÑÒ² ÏÐÎÁ²ÎÒÈ×ÍÈÕ ØÒÀ̲ ̲ÊÐÎÁ²Â, ÙÎ ÂÕÎÄßÒÜ ÄÎ ÑÊËÀÄÓ Ë²ÎԲ˲ÇÎÂÀÍÈÕ ÊÎÌÅÐÖ²ÉÍÈÕ ÏÐÎÁ²ÎÒÈʲÂ, ÂÈÊÎÐÈÑÒÎÂÓªÌÈÕ Â ÏÐÀÊÒÈÖ² Ñîëîíèíà Í.Ë. VIABILITY AND ADHESIVE PROPERTIES OF BACTERIA PROBIOTIC STRAINS FROM THE LYOPHILIZED COMMERCIAL PROBIOTICS WHICH ARE USED IN PRACTICE Solonina N.L. Nowadays
probiotics are produced in lyophilized form in order to prolong the
shelf-life of the product. But the longitude of probiotic bacteria
cells inactivation stage can last up to 8-10 hours. In adult patients
with diarrhea syndrome and in infants the speed of food transport is
much higher and the major part of probiotic bacteria cells is naturally
eliminated from the host organism. The viability of microorganisms that
compose the basis of commercial probiotics used by health professionals
and veterinary surgeons in Ukraine was determined. It was shown that
viability of bacteria in commercial lyophilized probiotic preparations
during reactivation stage is displayed differentially. According to the
adhesion parameters highly adhesive microorganism cultures in
probiotics “Bifidumbacterin”, “Bificol” and “lactobacterin” were found.
It was proven that the quantity of viable cells decreases significantly
in “Colibacterin”, “Narine”, “Probifor” and “Subalin” when the
preparation’s lyophilized form is changed into the liquid form. The low
adhesion ability of microorganisms was shown for “Subalin”, “Linex”,
“Bifidumbacterin-forte”, “Narine” and “Probifor”.
Keywords:
probiotic, viability, adhesion. |
61-65 |
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| ÀÍÒÈÌÈÊÐÎÁÍÛÅ ÑÂÎÉÑÒÂÀ ÃÈÄÐÎÊÑÈÀÏÀÒÈÒÍÛÕ
ÏÎÊÐÛÒÈÉ Ñ ÑÎÄÅÐÆÀÍÈÅÌ ÕÈÒÎÇÀÍÀ È ÑÅÐÅÁÐÀ ÍÀ ÒÈÒÀÍÎÂÛÕ ÑÓÁÑÒÐÀÒÀÕ ÏÎ ÎÒÍÎØÅÍÈÞ Ê ÌÈÊÐÎÎÐÃÀÍÈÇÌÓ E. COLI ATCC 25922 Ñóõîäóá Ë.Á., Îñîëîä÷åíêî Ò.Ï., ßíîâñêàÿ À.À., Ðàä÷åíêî À.Å., Êó÷ìà È.Þ., Êàçìèð÷óê Â.Â., Âîëÿíñêèé Þ.Ë., Ñóõîäóá Ë.Ô. ANTIMICROBIAL PROPERTIES OF HYDROXYAPATITE COATINGS CONTAINING OF CHITOSAN AND SILVER ON TITANIUM SUBSTRATES IN RELATION TO MICROORGANISMS E.COLI ATCC 25922 Sukhodub L. B. , Osolodchenko T. P., Yanovska A. A., Radchenko Å. À., Kuchma I. Y., Kazmirchuk V. V., Volyansky Yu. L., Sukhodub L. F. In this work it
was studied the antibacterial properties of coatings based on HA, with
Chitosan and silver ions additions, produced by substrates
termodeposition method from aqueous solutions with varying
concentrations of Chitosan (0.025 and 0.1 g/l) and silver (1 mg/l) as
the antimicrobial components as well as three-part cover, consisting of
a film of Chitosan, HA and silver. Study on antibacterial properties of
composite coatings on the pathogen E.coli ATCC 25922 was held by
Spectrophotometric measurement and analysis of optical density of
suspensions, containing samples. 3 series of measurements data were
averaged. The results showed that the concentration of antimicrobial
components have indicated a bacteriostatic effect of coatings on the
culture of E. coli AS ATCC 25922 in physiological solution at a
temperature of 37 °C. The most effective was the three-part cover
consisting of a film of chitosan, HA and silver.
Keywords:
hydroxyapatite, Chitosan, silver, microorganism E. coli, optical
density, antibacterialactivity. |
66-73 |
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| ÐÀÇÐÀÁÎÒÊÀ ÎÑÍÎÂÍÛÕ ÏÎËÎÆÅÍÈÉ ÑÀÍÈÒÀÐÍÛÕ
ÍÎÐÌ È ÏÐÀÂÈË ÝÏÈÄÅÌÈÎËÎÃÈ×ÅÑÊÎÉ ÁÅÇÎÏÀÑÍÎÑÒÈ ÔÎÍÒÀÍΠÓÊÐÀÈÍÛ È ÐÎÑÑÈÈ Ìàíóéëîâ Ì.Á., Ìàðòûíîâ À.Â., Ìàíüêîâñêèé Â.Â. DEVELOPMENT OF THE MAIN PROVISIONS OF SANITARY NORMS AND RULES EPIDEMIOLOGICAL SAFETY FOUNTAINS OF UKRAINE AND RUSSIA Manuilov MB, Martynov AV, Mankovsky VV The article
presents the main points of sanitary norms and rules of operation of
fountains operating in recirculation mode (water recycling) and their
water supply from water bodies or water supply systems (flow mode),
developed on the basis of standards of operation of swimming pools.
Based on a proposal formulated standards specifications applicable to
the disinfection system and water purification fountains operating in
recirculation mode, implemented in the form of technology based on the
bactericidal properties of silver ions and copper. The presented
approach to biosecurity fountains found support from the Ministry of
Health of Ukraine and has been the basis of input sanitary norms and
regulations will come into effect in 2013.
Keywords:
fountains, standards specifications, silver ions and copper |
74-82 |
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| ÂÈÇÍÀ×ÅÍÍß ÍÀßÂÍÎÑÒ² ËÅÊÒÈÍ²Â Ó ÑÈÐÎÂÈͲ
ÊÓÊÓÐÓÄÇÈ ÇÂÈ×ÀÉÍί ÒÀ ÂÈÂ×ÅÍÍß ËÅÊÒÈÍÎÂί ÀÊÒÈÂÍÎÑÒ² Êàðïþê Ó.Â., Êèñëè÷åíêî Â.Ñ. IDENTIFICATION OF LECTINS OF ZEA MAYS RAW MATERIAL AND THE STUDY OF LECTIN ACTIVITY Karpiuk UV., Kyslychenko VS. The aime of the
study was to identify lectins in the Zea mays raw material: roots,
stems, heads, leaves and corn silk and study their activity. Lectins
activity has been studied using the biological method of
ratuserytroagglutination. This method is based on formation of
aggregates of lectins and rats erythrocytes. The activity unit was the
floor amount of lectins that agglutinate erythrocytes. The protein
nature of extracts that agglutinate has been determined using Bradford
method. The lectins activity of Zea mays roots was 6,21±0,11 unit/mg of
protein; of heads – 2,61±0,17 unit/mg of protein; of leaves – 0,62
±0,05 unit/mg of protein; of corn silk – 1,06±0,08 unit/mg of protein;
of stems – 0,97±0,09 unit/mg of protein. The greatest lectins activity
was in leaves, stems and corn silk.
Keywords:
Zea mays, lectins, lectin activity |
83-85 |
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| ËÅÊÖ²¯
(LECTURES) ÁÀÊÒÅÐÈÀËÜÍÛÅ ÁÈÎÏËÅÍÊÈ È ÈÍÔÅÊÖÈÈ (Ëåêöèÿ) ×åðíÿâñêèé Â. È. BACTERIAL BIOFILMS AND INFECTION (LECTURE) Chernjavsky V.I. The lecture
presents published data on the biofilm – a special from of organization
of the microflora of the human body, the role of microbial biofilms in
the genesis and development of many common diseases. Different
mechanisms of antimicrobial resistance development in biofilm are
reviewed in the article.
Key words: bacterial
biofilms, extracellular matrix, dynamic and static methods,
antimicrobial resistanse |
86-90 |
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