Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÐÎËÜ ÏÐÎÁÈÎÒÈÊΠ ÌÈÊÐÎÝÊÎËÎÃÈÈ ×ÅËÎÂÅÊÀ ×åïóðíàÿ Ì.Í., Áàáè÷ ª. Ì. THE ROLE OF PROBIOTICS IN HUMAN MICROECOLOGY Chepurnaya M. N., Babich E. M. Today
the number of violations in dysbiotic microflora of the
gastrointestinal tract increases. This is a consequence of many
factors: the effect of negative environmental factors, the uncontrolled
use of antibiotics, reduced adaptive capacity of the organism, etc.
Probiotic preparations are widely used in the clinical practice to
solve the problem of dysbiosis. The properties of probiotics, their
impact on the human body and mechanisms of actions of probiotics are
presented in the review. The modern requirements for probiotic
microorganisms and preparations-probiotics are described in the article.
Key words: intestinal microflora, disbacteriosis, probiotics |
5-12 |
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| ÑÎÄÅÐÆÀÍÈÅ ÁÀÇÀËÜÍÎÃÎ ÓÐÎÂÍß ÏÎËÎÂÛÕ ÃÎÐÌÎÍÎÂ È ÃÎÐÌÎÍÎÂ ÃÈÏÎÔÈÇÀ Â ÊÐÎÂÈ ÁÎËÜÍÛÕ ÄÅÌÎÄÅÊÎÇÎÌ Áîäíÿ Å.È., Ðåâåíêî Æ.À. CONTENTS BASAL LEVELS of SEX HORMONES and PITUITARY HORMONES IN PATIENTS DEMODECOSIS Bodnya K.I., Revenko Zh.A. The regularities of changes in the nature and
dynamics of clinical – hormonal parameters are revealed in this
research that are not being
specific they expand knowledge of the pathogenesis of demodicosis and
create certain conditions for the directed correction of compensatory
and adaptive capabilities of the host and open up prospect for
improvement – pathogenetic treatment of demodicosis and its
complications.
Keywords: demodecos, sex hormones, pituitary hormones.
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10-13 |
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| ÈÌÌÓÍÈÒÅÒ È ÖÅÍÒÐÀËÜÍÀß ÍÅÐÂÍÀß ÑÈÑÒÅÌÀ (ÖÍÑ) ÏÐÈ ÕÐÎÍÈ×ÅÑÊÎÌ ÏÐÈÎÁÐÅÒÅÍÍÎÌ ÒÎÊÑÎÏËÀÇÌÎÇÅ Áîäíÿ Å.È., Áîáðîâà Î.Â., Êîöûíà Ñ.Ñ., Âåðíèãîðà È.È. IMMUNITY AND CENTRAL NERVOUS SYSTEM (CNS) CHRONIC ACQUIRED TOXOPLASMOSIS Bodnya K.I., Bobrova O.V., Kotsyna S.S., Vernigora I.I. When
chronic acquired toxoplasmosis (ÑÀT) the regularities of changes in the
ratio of the immune system (CD3, IRI, total immunoglobulins) and the
functional state of the central nervous system (EEG changes on
stem-diencephalic type) available informative methods, which made it
possible to evaluate the severity of the flow chart and predict
treatment outcome without resorting to complex research methods. Found
that the host-parasite relationships and clinical manifestations of
chronic toxoplasmosis depend largely on protective and adaptive responses and compensatory abilities of the human body.
Keywords: toxoplasmos, immune system, clinical manifestations. |
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| ÒÅÎÐÈß ÂÅÊÒÎÐÍÎÉ ÀËÃÅÁÐÛ Â ÀÍÀËÈÇÅ ÑÂÎÉÑÒ ÀÍÒÈÌÈÊÐÎÁÍÛÕ ÏÐÅÏÀÐÀÒΠÁîéêî Í. Í., Çàéöåâ À. È., Îñîëîä÷åíêî Ò. Ï. VECTOR ALGEBRA THEORY IN ANALISIS OF PROPERTIES OF ANTIBACTERIAL MEDICATIONS Boyko N. N., Zaytsev A. I., Osolodchenko T. P. The possibility to use vector algebra theory for quantitative description of antibacterial medications and comparison of their properties has
been shown. Mathematic formulas for description of medications’
antibacterial action basing on data of simple to use well method have
been presented. This method allows evaluation of medications’
antibacterial activity and opportunity to choose the most active ones,
as well as compare them with each other. It is noted that medications
of natural origin are inferior to those of synthetic origin as for
their antibacterial activity, and new galenic medications possess the
most antimicrobial properties. The prospects of this method for
pharmacoeconomic analysis of medications conducted in order to chose
optimal cost/quality ratio has been demonstrated.
Keywords: vector algebra, antibacterial properties of medications. |
20-26 |
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| ÈÍÔÅÊÖÈÎÍÍÀß ÏÀÒÎËÎÃÈß ÌÀÒÅÐÈ È ÅÅ ÂËÈßÍÈÅ ÍÀ ÀÍÒÐÎÏÎÌÅÒÐÈ×ÅÑÊÈÅ ÏÎÊÀÇÀÒÅËÈ ÍÎÂÎÐÎÆÄÅÍÍÛÕ Ìàðêîâñêèé Â.Ä., Ñîðîêèíà È.Â., Ìèðîøíè÷åíêî Ì.Ñ., Ïëèòåíü Î.Í. INFECTIOUS PATHOLOGY OF MOTHER AND ITS INFLUENCE ON THE ANTHROPOMETRIC PARAMETERS OF NEWBORNS Markovsky V.D., Sorokina I.V., Myroshnychenko M.S., Pliten O.N. The presence in
pregnant woman foci of latent, chronic infection of any localization is
an important cause of various complications during pregnancy,
childbirth, a wide range of perinatal pathology. The purpose of this
study was to reveal the influence of mother infectious diseases on the
anthropometric parameters of newborns. The authors set up an experiment
on WAG rats on modeling subacute (prolonged) peritonitis in females in
order to study the influence of this infectious-inflammatory process in
the organism of mother on the anthropometric parameters of newborns.
The study found that the presence of infectious-inflammatory diseases
in mother is not always leads to inflammatory changes in the placenta,
but involutive- degenerative and dyscirculatory changes are taking
place in all cases. In newborns from mothers with infectious pathology
revealed significantly reduced anthropometric parameters in comparison
with newborns from healthy mothers. Anthropometric parameters of
newborns from mothers with infectious pathology depend on the infective
dose (the higher the dose of agent, the less neonatal anthropometric
parameters). Negative influence of infectious extragenital pathology of
mother on newborn anthropometric parameters requires improving the
quality of pregravidal training aimed at early detection and sanitation
of foci of infection.
Keywords: infection, mother, anthropometric parameters, newborn. |
20-26 |
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ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ |
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Á²ÎËÎò×ÍÈÕ ÂËÀÑÒÈÂÎÑÒÅÉ ÏÐÎÁ²ÎÒÈ×ÍÈÕ ØÒÀ̲ LACTOBACILLUS SPP. ÏÐÈ
ÊÓËÜÒÈÂÓÂÀÍͲ ¯Õ  ÀÅÐÎÁÍÈÕ ÒÀ ̲ÊÐÎÀÅÐÎÔ²ËÜÍÈÕ ÓÌÎÂÀÕ Áàáè÷ ª. Ì., Êàë³í³÷åíêî Ñ.Â., Êîðîòêèõ Î.Î., Ðèæêîâà Ò. À., Ñêëÿð Í.²., Ìàñë³é ².Ã., Áàëàê À.Ê., Øêîäîâñüêà Í.Þ., Áàãà÷à Ì. Á. THE STUDY OF THE BIOLOGICAL PROPERTIES OF PROBIOTIC LACTOBACILLUS SPP. STRAINS UNDER AEROBIC AND MICROAEROPHILIC CULTIVATION CONDITIONS Babych E.M., Kalinichenko S.V., Korotkykh O.O., Ryzhkova T.A., Sklyar N.I., Maslii I.G., Balak A. K., Shkodovska N. Yu., Bagacha M. B. The
biological properties (growth characteristics, adhesive activity and
sensitivity to antimicrobial) of probiotic Lactobacillus strains were
studied under different gas composition of incubation atmosphere. It
was found that the number of viable lactobacilli cells in the one dose
of investigated probiotic preparations was lower than it was claimed by
the manufacturer. Gas composition of incubation atmosphere affects cell
viability of probiotic strains. The number of colony forming units of
lactobacilli under
microaerophilic conditions increased in 1,19-1,33 times as compared
with aerobic conditions. It was proved that adhesive activity of
probiotic Lactobacillus strains and sensitivity to 2th, 3th, 4th
generations of cephalosporins (cefuroxime, cefotaxime, cefepime) and
tetracyclines (doxycycline) also increased under microaerophilic
conditions. The changes of the biological properties of lactobacilli
under different cultivation conditions require further study for
optimization of correction of dysbiotic disorders.
Key words: probiotic strains, lactobacteria, adhesive properties, growth characteristics, susceptibility to antibiotics.
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33-37 |
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| ÄÎÑ˲ÄÆÅÍÍß ÀÍÒÈÁÀÊÒÅвÀËÜÍί ÀÊÒÈÂÍÎÑÒ² ÊÎÌÁ²ÍÎÂÀÍÈÕ ÏÐÅÏÀÐÀҲ ÄËß Ë²ÊÓÂÀÍÍß ÂÀòÍÎDz вÇÍί ÅÒ²ÎËÎò¯ Áîáðèöüêà Ë.Î., Îñîëîä÷åíêî Ò.Ï., Ðóáàí Î.À. ANTIBACTERIAL ACTIVITY OF COMBINATION DRUGS FOR TREATING VAGINOSIS DIFFERENT ETIOLOGIES Bobritskaya L.A., Osolodchenko T.P., Ruban E.A. Investigated the
antimicrobial activity of the combination preparation in capsules
"Meraflam" clinical of microbial strains isolated from patients with
bacterial vaginosis . Experimentally proved the therapeutic dose of 0.3
g ornidazole in combination with Flamini 0.05 g, improve tolerability
and expand the range of antibacterial action of the drug. In view of
the antimicrobial capacity of diclofenac sodium from the
combination of ofloxacin proposed for use in an integrated circuit -
inflammatory treatment of infectious diseases , including bacterial
vaginosis.
Key words: antibacterials preparations, capsule, ornidazole, flamini, diclofenac sodium |
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| ÇÍÀ×ÅÍÍß ÄÈÍÀ̲ÊÈ ÄÅßÊÈÕ ²ÍÒÅÐËÅÉʲͲ ÑÈÐÎÂÀÒÊÈ ÊÐβ Ó ÕÂÎÐÈÕ ÍÀ ÌÓËÜÒÈÐÅÇÈÑÒÅÍÒÍÈÉ ÐÅÖÈÄÈ ÒÓÁÅÐÊÓËÜÎÇÓ ËÅÃÅÍÜ Áóòîâ Ä.Î. THE VALUE OF THE DYNAMICS SOME INTERLEUKINS OF BLOOD SERUM IN PATIENTS WITH MULTIREZYSTENT RELAPSE PULMONARY TUBERCULOSIS Butov D.O. The
study of interleukin (IL)-2, IL-4 and IL-8 in 140 patients with
pulmonary tuberculosis and 30 healthy donors. In patients with
pulmonary tuberculosis before treatment was an increase levels of IL-2,
IL-8 and decrease IL-4 compared to the relatively healthy donors. After
two-month standard antimycobacterial therapy found significant decrease
IL-2, IL-8 and increase IL-4 in patients with pulmonary tuberculosis.
More significant changes were expressed as before treatment so after
two months of chemotherapy were observed in patients with pulmonary
multirezystent pulmonary tuberculosis, especially in patients with
recurrent process than patients without the multirezystent pulmonary
tuberculosis and newly diagnosed pulmonary tuberculosis.
Keywords: multidrug-resistant tuberculosis, recurrent tuberculosis, newly diagnosed tuberculosis, immunity, cytokines, interleukin. |
43-47 |
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Ãðèöåíêî Â. ²., Ðóáàí Î. À., Îñîëîä÷åíêî Ò. Ï. RESEARCH ON MICROBIOLOGICAL PURITY OF “PHYTOPROST” AND “TAMSULOPROST” SUPPOSITORIES Gritsenko V.I., Ruban O.A., Osolodchenko T.P. Results
of the tests on microbiological purity of the test samples of
"Tamsuloprost" and "Phytoprost" suppositories for the treatment of
prostate diseases have shown that no viable cells of fungi were found
in the preparations, the number of viable cells of microorganisms is
within a norman rate. Studying the effectiveness of antimicrobial
preservatives it was found that the test samples meet criterion of the
requirements of the State Pharmacopoeia of Ukraine.
Keywords: microbiological testing, suppositories, prostate. |
48-52 |
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| ÓÄÎÑÊÎÍÀËÅÍÍß ÑÊËÀÄÓ ÒÀ ÒÅÕÍÎËÎò¯ ÒÀÁËÅÒÎÊ Ç Á²ËÊÎÌ ÑÎÍß×ÍÈÊÀ Ìàíñüêèé Î.À. IMPROVEMENT OF COMPOSITION AND TECHNOLOGY OF TABLETS WITH SUNFLOWER PROTEIN Manscy A.A. The
work is dedicated to the improvement of composition and technology of
tablets with plant proteins. As objects of research were chosen natural
compounds: sunflower protein and immunomodulator (mix-factor). The
manufacturing of tablets has been performed with preliminary wet
granulation. Substitution of moisturizer from purified water to
mix-factor. During the studies the new composition of immunomodulatory
tablets has been developed, which meets SPU requirements, water
substitution to mix-factor as a moisturizer has been justified, the
optimum parameters of technological process have been determined, on
the basis of experimental data it has been set that the granules are
tablettable with addition of a binder.
Key words: immunitet, protein, technology, tablets. |
53-56 |
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À̲ÍÎÊÈÑËÎÒÍÈÉ ÏÓË ÊÐβ IJÒÅÉ, ÕÂÎÐÈÕ ÍÀ ÀËÅÐòÉͲ ÇÀÕÂÎÐÞÂÀÍÍß
AMINO ACID BLOOD POOL OF CHILDREN WITH ALLERGIC DISEASES The
amino acid blood pool of children with atopic dermatitis, bronchial
asthma, urticaria, angioedema was investigated. The variability of
blood plasma amino acid content (tryptophan, histidine, tyrosine,
cysteine, methionine) was observed. The changes of histidine and
tryptophan levels might be connected with the formation of biogenic
amines, such as histamine, serotonine, with take part in the
development of allergic reactions and inflammatory processes in
organism.
Kew words: aminoacidical pool of blood, bronchial astma, atopic dermatitis, urticaria, angioedema |
57-60 |
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| ÃÅÒÅÐÎÃÅÍͲÑÒÜ ÏÎÏÓËßÖ²¯ ÑÒÀÔ²ËÎÊÎʲ ÇÀ ÎÇÍÀÊÎÞ ÌÅÒÈÖÈ˲ÍÐÅÇÈÑÒÅÍÒÍÎÑÒ² Êîöàð Î. Â., Âîðîíê³íà ².À., Äåðêà÷ Ñ. À., Êðèëîâà ². À., Ãàáèøåâà Ë.Ñ. HETEROGENEITY OF STAPHYLOCOCCUS POPULATION ON THE BASIS OF METYTSYLIN RESISTANCE Kotsar O.V., Voronkina I.A., Derkach S.A., Krylova I.A., Gabisheva L.S. 57 Staphylococcus
strains were identified and excluded from patients. Metytsylin
resistance of these strains was determined using disc-diffusion method
and method of serial dilutions with oxacillin MIC determination. In in
vitro studies of heterogeneity for the cultures with metytsylin
resistance was revealed. Expression of heterogeneity was shown to be
more typical for strains with low and average levels of oxacillin MICs.
Keywords: staphylococcal infection, metytsylin resistance, heterogeneity. |
61-65 |
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| ÎÑÎÁÅÍÍÎÑÒÈ ÔÀÐÌÀÊÎÒÅÐÀÏÈÈ ÑÀÕÀÐÍÎÃÎ ÄÈÀÁÅÒÀ 2-ÃÎ ÒÈÏÀ Òðèùóê Í. Ì. FEATURES PHARMACOTHERAPY OF DIABETES MELLITUS II TYPE Tryshchuk N. M. Epidemiological
increased incidence of diabetes mellitus is still ongoing. Treatment of
patients with diabetes mellitus is challenging due to several factors:
low level of diagnostics, difficulties in choice of drugs, the limited
use of self-monitoring of glucose by patients, clinical failure
medicines. Article defines the main groups of drugs that are needed for
the treatment of diabetes mellitus type 2, based on the mechanism of
action, dosage, side effects, contraindications and applications of
algorithms. These articles will help to rationally choose hypoglycemic
drugs for patients with diabetes mellitus type 2, thereby improving the
condition of diabetics and reducing the risk of
complications. Key words: pharmacotherapy, diabetes mellitus II type |
66-74 |
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Ê 100-ËÅÒÈÞ ÑÎ ÄÍß ÐÎÆÄÅÍÈß ÂÈÐÓÑÎËÎÃÀ, ÀÊÀÄÅÌÈÊÀ ÂÈÊÒÎÐÀ ÌÈÕÀÉËÎÂÈ×À ÆÄÀÍÎÂÀ Äèâî÷à Â.À. |
75-80 |
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