Annals of Mechnikov's Institute 2012 2
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Contents)



C. (P.)


(Editorial Board)

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(Contents)

2-4

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(REVIEWS)




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PHARMACOTHERAPY PROBLEMS IN COMMUNITY-ACQUIRED PNEUMONIA TREATMENT
Kireev I.V., Bacumenko M.G., Dobra O.O., Kniszhenko I.B.
Treatment of patients with CAP group II is an outpatient, patients receiving antibiotics per os. Aminopenicillines ( with clavulonate) or cephalosporins are combined with macrolides (azithromycin) in the treatment. Evaluation of the effectiveness of emergency treatment in all cases assessed within 48 hours of treatment. Clinical improvement observed in 90% of empiric therapy. Note that related conditions do not affect the choice of antibiotic therapy. Antibacterial therapy is directed against the pathogen (typical and atypical) and not against the related factors. Comorbidity is an important prognostic factor and influences the severity index of community acquired
pneumonia, but does not play a role in the choice of antibiotic.


5-12

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MODERN METHODS OF TREATMENT OF PERITONITIS IS CAUSED BY HOSPITAL BACTERIA STRAINS
Kosilova O.J.
In this article modern literature data about peritonitis treatment are analyzed and direct etiological role of E .col for nosocomial pyo-inflammation infections is determined. Modes sequence of antibiotic  resistance formation are described and possible ways of effective treatment are presented.
Key words: intraabdominal infections, peritonitis, antibiotic resistance, E.col.

13-16

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ANTIMICROBIC ACTION OF ANTIBIOTICS AND ANTISEPTIC TANKS AT PATIENTS OPERATED CONCERNING  DGPZ
Rymsha E. V.
The review of literature on microbic colonization of a prostate and bed of remote adenoma is presented. The problem of prevention and treatment of purulent-inflammatory complications after prostatectomy remains and is now urgent. The widespread introduction of prophylactic antibiotics leads to the selection of resistant strains of microorganisms, and increases the risk of superinfection. The growth of the number and  extended  multiresistant to antibiotics of  microorganisms  may  limit their use. This  does no t happen for antiseptics because of bacterial resistance  to  them  is  formed  slowly.  Proof  of  economic  and  clinical  benefits  of  using  antiseptics.  There  is  a positive  experience  in  providing  antimicrobial  properties  of  surgical  sutures,  urethral  and  vascular   catheters. Effective  antiseptics  are  surface-active  substances  known  to  a  wide  range  of  bactericidal,  virucidal,  fungicidal action  can  reduce  the  adhesive  properties  of  bacteria  and  destroy  microbial  toxins.  All  the  above  proves  the feasibility and the need for specialists active lens of criteria and approaches to the prevention of complications in the  preoperative,  intra-and  postoperative  periods,  as  well  as  a  comprehensive  approach  to  treatment,  with mandatory microbiological monitoring
Key words: microflora of a prostate and bed of remote adenoma, antibiotics, antiseptics,  athterassociate infection.

17-26

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MICROECOLOGY OF HUMAN AND ROLE OF PROBIOTIC PREPARATIONS IN THERAPY OF FESTERING-INFLAMMATORY DISEASES IN OBSTETRICS AND GYNAECOLOGY
Voyda Y. V., Solonina N. L.
The  microecological  system  of  man  is  an  aggregate  of  biocenoses,  each  of  which  is  characterized  individual specific  composition  of  microorganisms.  Damage  any  of  constituents  of  this  multicomponent  system,  caused endo-  and  exogenous  factors,  results  in  violation  of  equilibrium  of  the  system  and  serves  as  pre -condition  for development of microbial disbalance or infectious disease the way of autoinfection. As a result of this process it is possible to examine the increasing role of conditional pathogenic microorganisms at infectious diseases, including at  gynaecological  diseases  and  obstetric  pathology.  As  a  result  of  application  of  probiotics  it  is  possible considerably to improve the results of treatment of patients with different gynaecological diseases which always flow on a background disbiotical disorders. However mu ch efficiency of probiotical therapy in a large measure depends on composition and medical prophylactic features of biopreparation.
Keywords: biocenose, normal microflora, disbios, probiotic


27-37

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(EXPERIMENTAL STUDY)



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FRACTIONAL COMPOSITION OF INDUSTRIAL TETANUS TOXOID AND DIPHTHERIA TOXIN
Babych Ye.M., Kalinichenko S.V., Ryabovol E.V., Ryzhkova T.A., Sklyar N.I., Zhdamarova L.A., Bilozerskii V.I.,  Plugator T.M., Bobyreva I.V., Bolshakova G.M.
Fractional  composition  of  industrial  diphtheria  toxin  and  tetanus  toxoid  was  determined  with  the  use  of  gel filtration chromatography. It was established, that with the exception of specific antigenic  structures, diphtheria toxin and tetanus toxoid contained ballast proteins.
Key words: diphtheria toxin, tetanus toxoid, chromatography.

38-42

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MONITORING OF DRUG RESISTANCE MYCOBACTERIUM TUBERCULOSIS BY SMEAR ELIMINATERS OF DIFFERENT CATEGORIES IN KHARKIV REGION DURING THE PERIOD 2006-2011
Kuchma I.Yu., Kovalyova G.O., Gushylyk B.I.
Determined  by  the  frequency,  structure  and  profile  of  drug  resistance  (DR)  in  tuberculosis  smear  of  different categories.  Strains of  multidrug-dominated (63.7%) in the secondary  structure of  DR increased the number of  Rresistant and decreased E-resistant strains (10.0%). The profile  mono-resistance least  - E  (11.6%) and R-(15,4%), most  others  -  S-resistant  strains  (47.38%).  Among  the  newly  diagnosed  smear  incidence  of  resistant  strains  of MBT was the highest of all first-line drugs.
Key words: monitoring, frequency, resistance, sensitivity, strains.

43-50

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ANALISIS OFANTIMICROBIAL ACTIVITY OF ANTISEPTIC TABLETS TO MICROORGANISMS
Zhornyak O. I.
Antimicrobial activity of antiseptic tablets septefril, sebidin, septolette, ephisol, adzhysept results have been given in this article. Research results that we have got, point to great perspective of septefril, sebidin, septolette, ephisol, adzhysept antiseptic usage for treatment and prophylaxis inflammatory-purulent diseases.
Key Words: antiseptic pills, septefril, sebidin, septolette, ephisol, adzhysept.


51-54

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ANTIBACTERIAL PROPERTIES OF HOLMIUM TO CAUSATIVE AGENTS OF SUPPURATIVE -INFLAMMATORY COMPLICATIONS IN PATIENTS WITH TRAUMA
Lebedeva N.Yu., Poddubnaya H. N.
Article  denotes  to  determination  of  antibacterial  action  of  polyoxometalate  holmium  to  causative  agents  of suppurative-inflammatory  process  in  wounds  of  patients,  which  were  suffered  from  trauma.  Method  of  serial dilutions  was  used  for  determination  of  minimal  inhibiting  concentration  (MIC)  of  holmium  to  staphylococci, enterococci and E. coli. Registration of holmium action shows the strong antibacterial influence to staphylococci and enterococci (MIC of holmium action to staphylococcal and enterococcal strains same 1 10 M, to strains of E.coli 2,5 10 M). Solutions of holmium dont have antibacterial action to strains of E.coli.
Key words: Holmium, Antibacterial action
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55-58

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FEATURES OF ETIOLOGIC SPECTRUM OF BRONCHIAL ASTHMA FOR CHILDREN DEPENDING ON SEX AND AGE
Shmulich V.K., Prokhorenko A.A., Shmulich O.V., Staruseva V.V., Zimbal V.N.
In this work there are presented the results of allergy testings of 695 children suffering from bronchial asthma. The aim of this study was the specification of casually significant allergen depending on sex and age. Results of testing  are  processed  by  a  method  of  the  mathematiical  analysis,  raised  in  nomograms  according  to  which, considering the nosological entity of disease, sex and age of a patient, it is possible to define causally significant allergen.

59-63

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: (Experimental articles: pharmacy)



ORAL LONG-ACTING PHARMACEUTICAL FORM OF INSULIN ON THE BASIS OF SELF-ORGANIZING KVASI-LIVING SYSTEM OF COMBINATORIAL PEPTIDES
Martynov A.V., Bomko T.V., Nosalskaya T.N., Farber B.S., Farber  S.B.
The  paper  discusses  the  results  of  studies  on  physical  and  chemical  properties  of  kvasi-living  self-organizing insulin-based system, and on the effectiveness of its oral administration. The purpose of the studies was to modify positively  charged  amino  acid  residues  into  negatively  charged  residues  of  dicarboxylic  acids.  The  process  of bioorganic combinatorial synthesis produced  more than 100 thousand fragments capable of self-organization in the  insulin  receptor.  Self-organization  is  due  to  the  fact  that  peptides  were  previously  a  part  of  the  whole  namely, insulin molecule. These peptides had small size, and could be easily absorbed by intestines. They also had  a  long  duration  of  circulation  in  blood  and  reacted  with  insulin  receptor  in  a  fashion  similar  to  injected insulin. It  is shown that a  single oral application of such system leads to statistically significant and sustained reduction  in  blood  glucose  levels  within  24  hours  of  application.  The  effect  is  observed  in  both  cases:  while taking the drug on an empty stomach, and  with glucose and food load up to 7.11 mmol / L. A single dose of the drug led to a plateau of stable glucose levels and prevented hypoglycemia and glucose level jumps when applied to rats (control group). The kvasi -living system was obtained by partial proteolysis of recombinant insulin with pepsin, followed by partial modification of peptides with succinic anhydride.
Key words: insulin, oral form, self-assembled quasi living, succinylated

64-70

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CORRELATION OF THE STRUCTURAL PECULIARITIES OF BIOACTIVE COMPOUNDS OF HERBAL REMEDY AND ITS PHARMACOLOGICAL VALUE
Shulga L.I.
Fatty  acids  in  lipophilic  fractions  of  the  herbal  composition  as  well  as  of  the  tincture  obtained  from  it  were detected and identified by the method of gas chromatography. The presence of this group of biologically active compounds  supplements  the  biological  value  of  the  herbal  medicine  since  fatty  acids  are  responsible  for  the manifestation of antimicrobial properties along with flavonoids and volatile compounds. An antimicrobial activity of  extraction  agents  was  experimentally  determined  in  regard  to  gram-positive  and  gram-negative microorganisms.
Key words: mixture of officinal plants, tincture, fatty acids, antimicrobial activity
71-75

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