Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÏÐÎÁËÅÌÛ ÔÀÐÌÀÊÎÒÅÐÀÏÈÈ ÍÅÃÎÑÏÈÒÀËÜÍÎÉ ÏÍÅÂÌÎÍÈÈ Â ÓÊÐÀÈÍÅ Êèðååâ È.Â., Áàêóìåíêî Ì.Ã., Äîáðà Å.À., Êíèæåíêî È.Á. PHARMACOTHERAPY PROBLEMS IN COMMUNITY-ACQUIRED PNEUMONIA TREATMENT Kireev I.V., Bacumenko M.G., Dobra O.O., Kniszhenko I.B. Treatment
of patients with CAP group II is an outpatient, patients receiving
antibiotics per os. Aminopenicillines ( with clavulonate) or
cephalosporins are combined with macrolides (azithromycin) in the
treatment. Evaluation of the effectiveness of emergency treatment in
all cases assessed within 48 hours of treatment. Clinical improvement
observed in 90% of empiric therapy. Note that related conditions do not
affect the choice of antibiotic therapy. Antibacterial therapy is
directed against the pathogen (typical and atypical) and not against
the related factors. Comorbidity is an important prognostic factor and
influences the severity index of community acquired
pneumonia, but does not play a role in the choice of antibiotic. |
5-12 |
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| ÑÓ×ÀÑͲ ϲÄÕÎÄÈ Â Ë²ÊÓÂÀÍͲ ÕÂÎÐÈÕ ÍÀ ÏÅÐÈÒÎͲÒ, ÙÎ ÂÈÊËÈÊÀÍÈÉ ØÏÈÒÀËÜÍÈÌÈ ØÒÀÌÀÌÈ ÁÀÊÒÅÐ²É Êîñ³ëîâà Î.Þ. MODERN METHODS OF TREATMENT OF PERITONITIS IS CAUSED BY HOSPITAL BACTERIA STRAINS Kosilova O.J. In this
article modern literature data about peritonitis treatment are analyzed
and direct etiological role of E .col³ for nosocomial pyo-inflammation
infections is determined. Modes sequence of antibiotic resistance
formation are described and possible ways of effective treatment are
presented.
Key words: intraabdominal infections, peritonitis, antibiotic resistance, E.col³. |
13-16 |
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| ÀÍÒÈ̲ÊÐÎÁÍÀ Ä²ß ÀÍÒÈÁ²ÎÒÈʲ ÒÀ ÀÍÒÈÑÅÏÒÈÊ²Â Ó ÓÐÎËÎò×ÍÈÕ ÕÂÎÐÈÕ Ðèìøà Î. Â. ANTIMICROBIC ACTION OF ANTIBIOTICS AND ANTISEPTIC TANKS AT PATIENTS OPERATED CONCERNING DGPZ Rymsha E. V. The review
of literature on microbic colonization of a prostate and bed of remote
adenoma is presented. The problem of prevention and treatment of
purulent-inflammatory complications after prostatectomy remains and is
now urgent. The widespread introduction of prophylactic antibiotics
leads to the selection of resistant strains of microorganisms, and
increases the risk of superinfection. The growth of the number
and extended multiresistant to antibiotics of
microorganisms may limit their use. This does no t
happen for antiseptics because of bacterial resistance to
them is formed slowly. Proof of
economic and clinical benefits of
using antiseptics. There is a positive
experience in providing antimicrobial
properties of surgical sutures, urethral
and vascular catheters. Effective
antiseptics are surface-active substances
known to a wide range of
bactericidal, virucidal, fungicidal action can
reduce the adhesive properties of
bacteria and destroy microbial toxins.
All the above proves the feasibility and the
need for specialists active lens of criteria and approaches to the
prevention of complications in the preoperative,
intra-and postoperative periods, as well
as a comprehensive approach to
treatment, with mandatory microbiological monitoring
Key words: microflora of a prostate and bed of remote adenoma, antibiotics, antiseptics, ñathterassociate infection.
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17-26 |
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| ÌÈÊÐÎÝÊÎËÎÃÈß ×ÅËÎÂÅÊÀ È ÐÎËÜ ÏÐÎÁÈÎÒÈ×ÅÑÊÈÕ ÏÐÅÏÀÐÀÒΠ ÒÅÐÀÏÈÈ ÃÍÎÉÍÎ-ÂÎÑÏÀËÈÒÅËÜÍÛÕ ÇÀÁÎËÅÂÀÍÈÉ Â ÀÊÓØÅÐÑÒÂÅ È ÃÈÍÅÊÎËÎÃÈÈ Âîéäà Þ.Â., Ñîëîíèíà Í.Ë. MICROECOLOGY OF HUMAN AND ROLE OF PROBIOTIC PREPARATIONS IN THERAPY OF FESTERING-INFLAMMATORY DISEASES IN OBSTETRICS AND GYNAECOLOGY Voyda Y. V., Solonina N. L. The
microecological system of man is an
aggregate of biocenoses, each of
which is characterized individual specific
composition of microorganisms. Damage any
of constituents of this multicomponent
system, caused endo- and exogenous
factors, results in violation of
equilibrium of the system and
serves as pre -condition for development of microbial
disbalance or infectious disease the way of autoinfection. As a result
of this process it is possible to examine the increasing role of
conditional pathogenic microorganisms at infectious diseases, including
at gynaecological diseases and obstetric
pathology. As a result of
application of probiotics it is possible
considerably to improve the results of treatment of patients with
different gynaecological diseases which always flow on a background
disbiotical disorders. However mu ch efficiency of probiotical therapy
in a large measure depends on composition and medical prophylactic
features of biopreparation.
Keywords: biocenose, normal microflora, disbios, probiotic |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| ÔÐÀÊÖ²ÉÍÈÉ ÑÊËÀÄ ÏÐÀÂÖÅÂÎÃÎ ÀÍÀÒÎÊÑÈÍÓ ÒÀ ÄÈÔÒÅвÉÍÎÃÎ ÒÎÊÑÈÍÓ ÏÐÎÌÈÑËÎÂÎÃÎ ÂÈÐÎÁÍÈÖÒÂÀ Áàáè÷ ª.Ì., Êàë³í³÷åíêî Ñ.Â., Ðÿáîâ³ë Î.Â., Ðèæêîâà Ò.À., Ñêëÿð Í.²., Æäàìàðîâà Ë.À., Á³ëîçåðñüêèé Â.²., Ïëóãàòîð Ò.Ì., Áîáèðåâà ².Â., Áîëüøàêîâà Ã.Ì. FRACTIONAL COMPOSITION OF INDUSTRIAL TETANUS TOXOID AND DIPHTHERIA TOXIN Babych Ye.M., Kalinichenko S.V., Ryabovol E.V., Ryzhkova T.A., Sklyar N.I., Zhdamarova L.A., Bilozerskii V.I., Plugator T.M., Bobyreva I.V., Bolshakova G.M. Fractional
composition of industrial diphtheria
toxin and tetanus toxoid was
determined with the use of gel filtration
chromatography. It was established, that with the exception of specific
antigenic structures, diphtheria toxin and tetanus toxoid
contained ballast proteins.
Key words: diphtheria toxin, tetanus toxoid, chromatography. |
38-42 |
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| ÌÎͲÒÎÐÈÍÃ
ÌÅÄÈÊÀÌÅÍÒÎÇÍί ÐÅÇÈÑÒÅÍÒÍÎÑÒ² ̲ÊÎÁÀÊÒÅÐ²É ÒÓÁÅÐÊÓËÜÎÇÓ Ó
ÁÀÊÒÅвÎÂÈIJËÞÂÀײ вÇÍÈÕ ÊÀÒÅÃÎÐ²É Ó ÕÀÐʲÂÑÜÊ²É ÎÁËÀÑÒ²
ÇÀ ÏÅвÎÄ 2006-2011 ð.ð. Êó÷ìà ².Þ., Êîâàëüîâà Ã.Î., Ãóøèëèê Á.². MONITORING OF DRUG RESISTANCE MYCOBACTERIUM TUBERCULOSIS BY SMEAR ELIMINATERS OF DIFFERENT CATEGORIES IN KHARKIV REGION DURING THE PERIOD 2006-2011 Kuchma I.Yu., Kovalyova G.O., Gushylyk B.I. Determined
by the frequency, structure and
profile of drug resistance (DR) in
tuberculosis smear of different categories.
Strains of multidrug-dominated (63.7%) in the secondary
structure of DR increased the number of Rresistant and
decreased E-resistant strains (10.0%). The profile
mono-resistance least - E (11.6%) and R-(15,4%), most
others - S-resistant strains (47.38%).
Among the newly diagnosed smear
incidence of resistant strains of MBT was the
highest of all first-line drugs.
Key words: monitoring, frequency, resistance, sensitivity, strains. |
43-50 |
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| ÀÍÀË²Ç ×ÓÒËÈÂÎÑÒ² ̲ÊÐÎÎÐÃÀͲÇ̲ ÄÎ ÒÀÁËÅÒÎÂÀÍÈÕ ÀÍÒÈÑÅÏÒÈ×ÍÈÕ ÏÐÅÏÀÐÀҲ Æîðíÿê Î. ². ANALISIS OFANTIMICROBIAL ACTIVITY OF ANTISEPTIC TABLETS TO MICROORGANISMS Zhornyak O. I. Antimicrobial
activity of antiseptic tablets septefril, sebidin, septolette, ephisol,
adzhysept results have been given in this article. Research results
that we have got, point to great perspective of septefril, sebidin,
septolette, ephisol, adzhysept antiseptic usage for treatment and
prophylaxis inflammatory-purulent diseases.
Key Words: antiseptic pills, septefril, sebidin, septolette, ephisol, adzhysept. |
51-54 |
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| ÀÍÒÈÁÀÊÒÅвÀËÜͲ
ÂËÀÑÒÈÂÎÑÒ² ÏÎ˲ÎÊÑÎÌÅÒÀËÀÒÓ ÃÎËÜÌ²Þ ÏΠ²ÄÍÎØÅÍÍÞ ÄÎ ÇÁÓÄÍÈʲÂ
ÃͲÉÍÎ-ÇÀÏÀËÜÍÈÕ ÓÑÊËÀÄÍÅÍÜ Ó ÏÎÑÒÐÀÆÄÀËÈÕ ²Ç ÒßÆÊÈÌÈ ÒÐÀÂÌÀÌÈ Ëåáåäºâà Í.Þ., ϳääóáíà Î.Ì. ANTIBACTERIAL PROPERTIES OF HOLMIUM TO CAUSATIVE AGENTS OF SUPPURATIVE -INFLAMMATORY COMPLICATIONS IN PATIENTS WITH TRAUMA Lebedeva N.Yu., Poddubnaya H. N. Article
denotes to determination of antibacterial
action of polyoxometalate holmium to
causative agents of suppurative-inflammatory
process in wounds of patients,
which were suffered from trauma.
Method of serial dilutions was used
for determination of minimal inhibiting
concentration (MIC) of holmium to
staphylococci, enterococci and E. coli. Registration of holmium action
shows the strong antibacterial influence to staphylococci and
enterococci (MIC of holmium action to staphylococcal and enterococcal
strains same 1 10 M, to strains of E.coli – 2,5 10 M). Solutions of
holmium don’t have antibacterial action to strains of E.coli.
Key words: Holmium, Antibacterial action .
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55-58 |
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| ÎÑÎÁËÈÂÎÑÒ² ÅÒ²ÎËÎò×ÍÎÃÎ ÑÏÅÊÒÐÓ ÁÐÎÍÕ²ÀËÜÍί ÀÑÒÌÈ Ó Ä²ÒÅÉ ÇÀËÅÆÍÎ Â²Ä ÑÒÀÒ² ÒÀ ²ÊÓ Øìóë³÷ Â.Ê. , Ïðîõîðåíêî Î.À., Øìóë³÷ Î.Â., Ñòàðóñåâà Â.Â., Öèìáàë Â.Ì. FEATURES OF ETIOLOGIC SPECTRUM OF BRONCHIAL ASTHMA FOR CHILDREN DEPENDING ON SEX AND AGE Shmulich V.K., Prokhorenko A.A., Shmulich O.V., Staruseva V.V., Zimbal V.N. In this
work there are presented the results of allergy testings of 695
children suffering from bronchial asthma. The aim of this study was the
specification of casually significant allergen depending on sex and
age. Results of testing are processed by
a method of the mathematiical
analysis, raised in nomograms according
to which, considering the nosological entity of disease, sex and
age of a patient, it is possible to define causally significant
allergen.
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59-63 |
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| Åêñïåðèìåíòàëüí³ ðîáîòè: ôàðìàö³ÿ (Experimental articles: pharmacy) |
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| ORAL LONG-ACTING PHARMACEUTICAL FORM OF INSULIN ON THE BASIS OF SELF-ORGANIZING KVASI-LIVING SYSTEM OF COMBINATORIAL PEPTIDES Martynov A.V., Bomko T.V., Nosalskaya T.N., Farber B.S., Farber S.B. The
paper discusses the results of
studies on physical and chemical
properties of kvasi-living self-organizing
insulin-based system, and on the effectiveness of its oral
administration. The purpose of the studies was to modify
positively charged amino acid residues
into negatively charged residues of
dicarboxylic acids. The process of bioorganic
combinatorial synthesis produced more than 100 thousand fragments
capable of self-organization in the insulin receptor.
Self-organization is due to the
fact that peptides were previously
a part of the whole –namely, insulin
molecule. These peptides had small size, and could be easily absorbed
by intestines. They also had a long duration
of circulation in blood and reacted
with insulin receptor in a fashion
similar to injected insulin. It is shown that a
single oral application of such system leads to statistically
significant and sustained reduction in blood
glucose levels within 24 hours of
application. The effect is observed
in both cases: while taking the drug on an empty
stomach, and with glucose and food load up to 7.11 mmol / L. A
single dose of the drug led to a plateau of stable glucose levels and
prevented hypoglycemia and glucose level jumps when applied to rats
(control group). The kvasi -living system was obtained by partial
proteolysis of recombinant insulin with pepsin, followed by partial
modification of peptides with succinic anhydride.
Key words: insulin, oral form, self-assembled quasi living, succinylated |
64-70 |
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| CORRELATION OF THE STRUCTURAL PECULIARITIES OF BIOACTIVE COMPOUNDS OF HERBAL REMEDY AND ITS PHARMACOLOGICAL VALUE Shulga L.I. Fatty
acids in lipophilic fractions of
the herbal composition as well as
of the tincture obtained from it
were detected and identified by the method of gas chromatography. The
presence of this group of biologically active compounds
supplements the biological value of
the herbal medicine since fatty
acids are responsible for the manifestation of
antimicrobial properties along with flavonoids and volatile compounds.
An antimicrobial activity of extraction agents
was experimentally determined in regard
to gram-positive and gram-negative microorganisms.
Key words: mixture of officinal plants, tincture, fatty acids, antimicrobial activity |
71-75 |
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