Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-5 |
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ÎÃËßÄÈ (REVIEWS) |
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| CÊÀÇ Â ÓÊÐÀ¯Í²: ÅϲÄÅ̲×ÍÀ ÒÀ ÅϲÇÎÎÒÈ×ÍÀ
ÑÈÒÓÀÖ²ß, ÇÀÑÎÁÈ ÄËß ÏÐÎÔ²ËÀÊÒÈ×Íί ÒÀ ˲ÊÓÂÀËÜÍÎ-ÏÐÎÔ²ËÀÊÒÈ×Íί ²ÌÓͲÇÀÖ²¯ Íîâèêîâà Î.Þ., Ëàâðèê O.À., Ïàí÷åíêî Ë.Î. RABIES IN UKRAINE: EPIDEMIOLOGICAL AND EPIZOOTIC SITUATION, MEANS FOR PREVENTIVE AND THERAPEUTIC IMMUNIZATION Novikova O., Lavrik A., Panchenko L.
Epidemiological and epizootic situations of rabies in Ukraine were
analyzed. Active centers of animal rabies formed in many areas where 2016 persons were attacked by animals
(mostly dogs suspected on rabies) during 2011 year. Characteristics of preparates on rabies
prevention, and basic methods of analyzing the specific activity of rabies vaccines were described.
Keywords: epidemic and epizootic situation on rabies, rabies vaccine, rabies immunoglobulin. |
6-9 |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ ÐÎÁÎÒÈ, ÌÅÄÈÖÈÍÀ (EXPERIMENTAL STUDY, MEDICINE) | ||
PHARMACEUTICAL CARE IN THE TREATMENT OF PATIENTS WITH INFECTIONS OF THE LOWER URINARY TRACT Moroz V.A.
In order to monitor changes in the recommendations for drug treatment
of lower urinary tract infections (UTI) and pharmaceutical care of patients analyzed resolution and
related publications of American Urological Association at the end of 2012. Marked improvement of detail
factors of chronicity UTI and allocation of roles pharmacist to prevent its recurrence. In the
arsenal of treatments for uncomplicated disease (about 80%) left Co-trimoxazole, but exclude the scheme of its
single administration. In complicated UTI the use of recommended combinations of antibiotics
extended to 14 days, introduced the scheme extended use of Co-trimoxazole or fluoroquinolones in
bacterial prostatitis and epididymitis. Formulated the principles of pharmaceutical care of patients with UTI
and stated that this pathology are results from the interaction of several biomedical factors that must be
considered for the rational choice of treatment strategy. Implementation of pharmaceutical care of
patients with UTI is an important component of the treatment success
and prevention of disease recurrence.
Key words: urinary tract infections, pharmaceutical care, antibiotic
therapy, bacteriuria. |
10-15 |
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| ORMS IN SURPRISING PLACES: CLINICAL
AND MORPHOLOGICAL FEATURES Adeyemi A. A., Borzenkova I. V., Myroshnychenko M. S., Pliten O. N.
Helminthes are the most common human diseases, which are characterized
by involvement in the pathological process of all organs and systems. In this article, the
authors discuss a few cases of typical and atypical localizations for parasitic worms such as filarial and
pinworms which were recovered from surprising places in the bodies of patients in Kharkiv region. This
article will allow the doctors of practical health care to pay special attention to the timely prevention
and diagnostics of this pathology.
Keywords: helminthes, filarial, pinworm, localization, features. |
16-24 |
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| ÂÈßÂËÅÍÍß ÃÅͲ ÏÀÒÎÃÅÍÍÎÑÒ² Â
V.PARAHAEMOLYTICUS, ÂÈIJËÅÍÈÕ Â Ï²ÂÄÅÍÍÈÕ ÐÅòÎÍÀÕ ÓÊÐÀ¯ÍÈ Ïåòðåíêî Î.Â., Àëåêñåºíêî Â.Â., Ëèñåíêî Ç.À. RECOGNITION OF PATHOGENIC GENES IN V.PARAHAEMOLYTICUS, ISOLATED IN SOUTHERN REGIONS OF UKRAINE Petrenko O. V., Alekseenko V.V., Lysenko Z.A.
Study of genetic determinants of V.parahaemolyticus showed a
correlation between geno- and phenotypic attributes of parahaemolytic vibrios. Presence of pathogenic
genes tdh or trh in parahaemolytic vibrios genome, which are responsible for TDH and TRH
hemolysins production, indicates their virulent properties, which in turn are exhibited by
vibrios in haemolytic activity.Application of molecular-genetic studies along with other
methods of differentiation of V.parahaemolyticus allows for accelerating and improving its laboratory
diagnostics.
Keywords: vibrios, V.parahaemolyticus, halophiloses, hemolysins, pathogenic genes.
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25-28 |
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| ÂÈÑÕ²ÄÍÈÉ ØËßÕ ²ÍÔ²ÊÓÂÀÍÍß ÏËÎÄÓ ÒÀ
ÔÎÐÌÓÂÀÍÍß ÊÈØÊÎÂÎÃΠ̲ÊÐÎ- Á²ÎÖÅÍÎÇÓ Ó ÍÎÂÎÍÀÐÎÄÆÅÍÈÕ Ä²ÒÅÉ Êóíîâñüêà Ë.Ì. ASCENDING WAY INFECTION NEWBORNS AND THE FORMATION OF INTESTINAL MICROBIOCENOSIS OF THE NEWBORN Kunovskaya L. M.
The role and value of the bacterial factor in development pre-natal
infection of newborns is studied. It is considered microflora of patrimonial ways of pregnant women, as basic
pathogenesis factor of an ascending way infection of newborns. On an example of the spent
bacteriological researches correlation communication between microflora of patrimonial ways, placenta and an
ascending way in fection of newborns is shown. At crops gastric swallowing at newborn children with
pre-natal infection of new borns it is ascertained growth aerobic and
àanaerobic microflora in the majority (87,7 %) supervision in the form of microbes associations
gramme-positive coccus Staphy lococcus
epidermidis and Staphylococcus aureus and Candida. The
inclusion in the treatment of
Saccharomyces boulard³i contributes to the restoration of intestinal microflora in 90 % of
newborns. Found significant growth of the colonies of Bifidobacterium spp. (3.7-4,9 lg CFU/ml) and
Lactobacillus spp. (7.2 lg CFU/ml).
Keywords:pre-natal infection of newborns, microflora, Saccharomyces boulard³i |
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| ÂËÈßÍÈÅ ÎÊÑÈÝÒÈËÈÐÎÂÀÍÍÛÕ ÀËÊÈËÔÅÍÎËΠÍÀ
ÃÎÐÌÎÍÀËÜÍÛÉ ÎÁÌÅÍ ÁÅËÛÕ ÊÐÛÑ Â ÏÎÄÎÑÒÐÎÌ ÝÊÑÏÅÐÈÌÅÍÒÅ Ìàðàêóøèí Ä.È., Íàêîíå÷íàÿ Î.À., Ìàêñèìîâà È.Ã. THE INFLUENCE OF OXYETHYLIZED ALKYLPHENOLS ON HORMONAL EXCHANGE OF WHITE RATS IN THE SUBACUTE EXPERIMENT Marakushin D.I., Nakonechnaya O.A., Maximova I.G.
The Influence of oxyethylized alkylphenols AF9-6, AF9-10 and AF9-12 has
been studied in doses 1/10 and 1/100 DL50on the hormonal profile of white rats in the conditions
of subacute experiment. It has been studied, that xenobiotics cause disturbances from the side of the
endocrine system at all level of its structurally-functional organization (hypothalamus – hypophysis –
thyroid and parathyroid glands – adrenal glands). Neonols manifest polytropic character of action on an
organism, which can be attended with formation of the multiple pathological states in the basis of
which membrane pathology lies.
Keywords: neonols, hormonal profile, oxyethylized alkylphenols. |
35-39 |
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| ×ÓÒËȲÑÒÜ ØÒÀ̲ ÑÒÀÔ²ËÎÊÎʲÂ, ÇÁÓÄÍÈʲÂ
ÃͲÉÍÎ-ÇÀÏÀËÜÍÈÕ ²ÍÔÅÊÖ²É, ÄÎ ÊÎÌÅÐÖ²ÉÍÈÕ ÏÐÅÏÀÐÀÒ²Â-ÁÀÊÒÅвÎÔÀò Äåðêà÷ Ñ.À., Âîðîíê³íà ².À., Êîöàð Î.Â., Êðèëîâà ².À., Ãîëîâåíüê³íà Í.À., Ãîëîâàõ³íà Ë.Ì. SUSCEPTIBLE STRAINS OF STAPHYLOCOCCI, AGENTS CHRONIC INFLAMMATORY INFECTION HAVE ACCESS TO COMMERCIAL PREPARATIONS OF BACTERIOPHAGE Derkach SA, Voronkina IA, Kotsar OV, Krylov IA, Golovenkina NA, Golovahina LM.
The wide spread of pathogenic microorganisms with a high resistance to
antibiotics causes the search fornew approaches to the treatment of patients with purulent-inflammatory
diseases. One promising area is the "resuscitation" and the improvement of phage therapy. Data on the
sensitivity of the circulating on the territory of Ukraine strains of staphylococci isolated from various
habitats of patients to drugs imported from Russia bacteriophages remain outstanding. We conducted a
study to determine fag's sensitivity S. aureus and CNS to staphylococcal bacteriophage,
sekstafags and piobakteriofags showed lytic activity of various antimicrobial agents. The most promising of
the drugs studied bacterio phages to treat staphylococcal disease in the Kharkov region is piobakteriofag.
Key words: Staphylococcus aureus, pyoinflammatory diseases,
bacteriophage |
40-44 |
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| ÀÏÎÏÒÎÇ ÔÀÃÎÖÈÒÓÞ×ÈÕ Ê˲ÒÈÍ, ²ÍÄÓÊÎÂÀÍÈÉ
̲ÊÎÁÀÊÒÅвßÌÈ ÒÓÁÅÐÊÓËÜÎÇÓ Ç Ð²ÇÍÎÞ Â²ÐÓËÅÍÒͲÑÒÞ ²ËܯÍÑÜÊÀ². Ô. , ÇÓÁвÉ×ÓÊ Î. Ì. APOPTOSIS INDUCTION IN THEPHAGOCYTIC CELLS BY MYCOBACTERIUM TUBERCULOSIS WITH DIFFERENT VIRULENCE Ilyinskaya I.F. , Zubriychuk O.M. The purpose of
this study was to investigate the characteristics of
phagocytic cells apoptosis induced in vitro and in vivo by
Mycobacterium tuberculosis with different
virulence. For this aim the main feachers of apoptosis of peritoneal
macrophages, neutrophyles,
monocytes, induced in vitro by living and dead MBT H37Rv and BCG in
intact animals, healthy subjects and
patients with tuberculosis were expected, as well as features of
apoptosis of neutrophils and
peritoneal macrophages of animals infected with MBT H37Rv and BCG. It
was found that the virulent Mycobacterium
tuberculosis have a powerful apoptogenic effect on phagocytic cells,
and the loss of pathogen
viability and virulence causes its weakening. It was demonstrated that
the induction of apoptosis by
Mycobacterium tuberculosis is realised both directly and indirectly,
probably through their influence on the production of cell interaction
mediators. It was detected that in order to limit excessive loss of
phagocytes due to apoptosis, virulent mycobacteria use mechanisms that
prevent infection of these cells.
Key words: apoptosis, peritoneal macrophages, neutrophils, monocytes, Mycobacterium tuberculosis, virulence, vitality, experimental tuberculosis, BCG vaccination. |
45-50 |
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| ÂÏËÈÂ ÏÅÐÎÐÀËÜÍÎÃÎ ÂÂÅÄÅÍÍß ÊÀØËÞÊÎÂÈÕ
ÀÍÒÈÃÅÍÍÈÕ ÏÐÅÏÀÐÀҲ ÍÀ ÄÅÐÌÎÍÅÊÐÎÒÈ×ÍÓ ÐÅÀÊÖ²Þ Ó ÊÐÎ˲ ªëèñåºâà ². Â., Áàáè÷ ª. Ì., Æäàìàðîâà Ë. À., Á³ëîçåðñüêèé Â. ²., ²ñàºíêî Î. Þ., Áîáèðºâà ². Â. INFLUENCE OF PREVIOUS ORAL APPLICATION OF PERTUSSIS ANTIGENIC PREPARATIONS ON RABBIT ALLERGIC REACTION FORMING AFTER SKIN TEST Yelyseyeva I. V., Babych Ye. M., Zhdamarova L. A., Belozersky V. I., Isayenko Ye. Yu., Bobireva I. V.
It’s studied an influence of previous oral application of pertussis
antigenic preparations, which obtained by the pertussis pathogen ultrasonic disintegration and centrifugation,
on allergic inflammation forming after skin test. Obtained results testify to the sensitizing effect of
high doses of the B.pertussis ultrasonic preparation and decreasing of hyperemia reaction when attenuating of
peroral dose of disintegration. Got out from B. pertussis microbe cells antigenic preparation appeared
considerably less reactogenious, nontoxic for neutrophilic leukocytes according to in vitro test and
showed a tendency to decreasing manifestation of rabbit skin reactions.
Key words: pertussis pathogen, antigenic preparations, oral imunization, skin allergic reaction. |
51-57 |
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| ̲ÊÐÎÁ²ÎÖÅÍÎÇ ÐÎÒÎÃËÎÒÊÈ Ó ÕÂÎÐÈÕ ÍÀ
ÒÓÁÅÐÊÓËÜÎÇ ËÅÃÅÍÜ Âèííè÷óê Ì.Î., Êëèìíþê Ñ.²., Âèííè÷óê Ë.Ð. OROPHARYNGEAL MICROBIOCENOSIS IN PATIENTS WITH PULMONARY TUBERCULOSIS Vynnychuk M.O., Klymnyuk S.I., Vynnychuk L.R.
Classical bacteriological method for examination of stomatopharynx
microflora in 58 patients with lung tuberculosis and 21 practically healthy persons subjects of both sexes,
aged from 18 to 43 years for revealing of microbiocenoses differences and justifying its correction
in patients with lung tuberculosis was used. The dysbiotic changes of stomatopharynx microbiocenosis with
lack of typical inhabitants of this biotope such as Lactobacilliand Fuzobacteria, as well as
appearance of Enterococcus spp. (12,1 %), Veillonella spp.(22,4 %) S. aureus, Pseudomonas spp. were observed in
patients with lung tuberculosis. The frequency of of Candida spp.carriage in tuberculosis patients was
in 2 times more, than in healthy persons and their colonization level was more too. But such index for
Neisseria spp.and Peptostreptococcus spp.carriage was less.
(p<0,05). Thus, use of antimycobacterial drugs deepens
sytomatopharynx dysbiosis. It must be taken into consideration during complex treatment
of patients with lung
tuberculosis. Key words: pulmonary tuberculosis, oropharynx, microbiocenosis. |
54-56 |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ, ÔÀÐÌÀÖ²ß/Õ²Ì²ß (EXPERIMENTAL STUDY, PHARMACY/CHEMISTRY) |
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| ÐÅÀÊÖ²ß ÀÐβËÌÅÒÈËÅÍÒÐÈÔÅͲËÔÎÑÔÎв˲IJ Ç
ÁÎÐÔÒÎÐÈÄÀÌÈ ÀÐÈËIJÀÇÎÍ²Þ ² ÏÐÎÒÈ̲ÊÐÎÁÍÀ ÀÊÒÈÂͲÑÒÜ ÔÎÑÔÎͲÉòÄÐÀÇÎͲ Ìàëàí÷óê Ñ.Ã. REACTION AROILMETHYLENTRIPHENILPHOSPHRILIDES WITH ARILDIASONIY BORPHTORIDES AND ANTIMICROBIAL ACTIVITY PHOSPHONIYHIDROSONES Malanchuk S. G.
The reactions of electrophilic accession borftoryds aryldizoniy by P-C
connection aroyilmetylentryphenylfosforilids were studied. Found that the reaction
formed borftoryds hidrazonofosfoniy salts. Studied the chemical and physical properties
and antimicrobial activity of synthesized compounds.
Keywords:borftoryds aryldiazoniy, aroyilmethylentryfenylfosforilids, fosfoniyhidrazony, α-azoaroyilmetylen- tryphenylphosphorilids, antimicrobial activity. |
65-69 |
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| ÑÈÍÒÅÇ ÒÀ
Ô²ÇÈÊÎ-ղ̲×Ͳ ÂËÀÑÒÈÂÎÑÒ² ÀÖÈËÜÎÂÀÍÈÕ ÒÀͲIJ Ìóñòàôà Àëü Õóññåéí, Ìàðòèíîâ À.Â. SYNTHESIS AND PHYSICO-CHEMICAL PROPERTIES OF ACYLATED TANNIN'S Mustafa Al Hussein, Martynov AV
One of the areas in the search for new pharmacologically active
compounds and the study is to obtain modified derivatives of natural substances. The goal was to synthesize
a series of acylated derivatives of gallo-and ellagitannins and explore their physical and chemical
properties. As a result, a number of studies have been synthesized acylated derivatives of the gallotannins
and ellagitannins and studied their physico-chemical properties. Tannin were obtained from a commercial
gallotannin and ellagotannins from alder cones. The main objectives of the study was to confirm the
possibility of establishing a stable esters between the phenolic groups of gallic acid and ellagic tannins
and acylating derivatives of dicarboxylic acids. The structure of the synthesized compounds is
confirmed using the method of thin layer chromatography and NMR 1Í. It is shown that only tannin, gallic
acid derivatives which are capable of forming a fully substituted phenyl for all available
hydroxyls. In the structure of ellagic acid derivatives - ellagitannins remain unsubstituted phenyl hydroxyls due
to the presence of steric hindrance.
Keywords: succin-ellagic acid, succin-gallic acid, succin-tannides, structure |
70-76 |
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| ËÅÊÖ²¯ (LECTURES) |
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| THE DIFFERENTIAL DIAGNOSIS OF CARDIOMEGALY
IN CHILDREN (Lecture) Holodnyak O.V.
The topic of the lecture is "The differential diagnosis of cardiomegaly
in children". The general symptoms of cardiomegaly, normal heart size and its cavities, depending
on age are shown. The differential diagnosis of cardiomegaly was made depending on the
etiology. Each year grows the number of children with heart disease of different etiology accompanied by the
increase of heart borders both locally and totally. We can influence on this process only through the
timely detection of disease, the differential diagnosis of heart disease and the appropriate treatment.
Keywords: cardiomegaly in children, differential diagnosis, heart failure, heart defects. |
66-73 |
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