Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÇÀÃÀËÜÍÎÁ²ÎËÎò×ÍÀ ÐÎËÜ ÁÀÊÒÅÐ²É ÐÎÄÓ PSEUDOMONAS  ÏÐÈÐÎIJ, ¯Õ Ê˲Ͳ×ÍÀ ÇÍÀ×ÓÙ²ÑÒÜ ÒÀ ×ÓÒËȲÑÒÜ ÄÎ ÀÍÒÈÁ²ÎÒÈʲ Âîëÿíñüêà Í.Ï. BIOLOGICAL ROLE OF PSEUDOMONAS BACTERIAS IN NATURE, THEIR CLINICAL ROLE AND SENSITIVENESS TO ANTIBIOTICS Volyanskaya N. P. Information
is resulted about distribution in nature of pseudomonads,
their taxonomical position in the hierarchy of
microbes, biological properties of typical type of P.aeruginosa
and also its sensitiveness to the antibiotics and
role in clinic.
Keywords: pseudomonads, role in nature, taxonomy, biology |
5-8 |
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| ÌÅÕÀÍÈÇÌÛ È ÐÅÃÓËßÖÈß ÔÀÇÎÂÛÕ È ÀÍÒÈÃÅÍÍÛÕ
ÂÀÐÈÀÖÈÉ ÁÀÊÒÅÐÈÉ Êîëîòîâà Ò.Þ., Áàëóòà È.Ì., Âîðîïàé À.Þ., Âàëü÷óê Ñ.È., Êó÷ìà È.Þ., Âîëÿíñêèé À.Þ., Ìàñëÿí÷óê Î.À. MECHANISMS AND REGULATION OF THE PHASE AND ANTIGENIC VARIATIONS OF BACTERIA Kolotova T.Yu., Baluta I.M., Voropay A.Yu., Val'chuk S.I., Kuchma I.Yu., Volyanskiy A.Yu., Maslyanchuk O.A. This
article discusses genetic mechanisms and regulation of the phase and
antigenic variations of prokaryotes. It is anticipated that studying
enzymes catalyzing genome rearrangements, which underlie phase and
antigenic variation, gives opportunity to create new drugs inhibiting
the enzymes catalytic activity and preventing the emergence of new
antigen or phase switching. While traditionally it has been believed
that genetic rearrangements are random, article summaries experimental
evidence, which prove regulation of the phase and antigenic variations
by the environmental conditions. Moreover some conditions of the
external environment, controlling genetic variation, are factors that
predict the future collision of the bacterial cells with selective
agents.
Key words: phase variation, antigenic variations, bacteria, genome rearrangement, recombination, environmental conditions, regulation. |
9-16 |
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| ÒÀÊÑÎÍÎÌÈß,
ÃÅÒÅÐÎÃÅÍÍÎÑÒÜ, ÝÏÈÄÅÌÈÎËÎÃÈ×ÅÑÊÀß È ÊËÈÍÈ×ÅÑÊÀß ÇÍÀ×ÈÌÎÑÒÜ ÁÀÊÒÅÐÈÉ
ÐÎÄÎÂ AEROCOCCUS, GLOBICATELLA, HELCOCOCCUS È FACKLAMIA (ÎÁÇÎÐ
ËÈÒÅÐÀÒÓÐÛ) Âàëü÷óê Ñ.È., Âîðîïàé À.Þ., Ïèëþãèí Ñ.Â., Êó÷ìà È.Þ., Âîëÿíñêèé À.Þ., Êðåìåí÷óöêèé Ã.Í. TAXONOMY, HETEROGENEITY, EPIDEMIOLOGICAL AND CLINICAL SIGNIFICANCE OF THE GENERA AEROCOCCUS, GLOBICATELLA, HELCOCOCCUS AND FACKLAMIA (REVIEW) Valchuk SI, Voropay AY, Pilyugin S.V, Kuchma I.Y ., Volyanskaya A.Y., Krementchutsry GN The
analysis of published data on the taxonomy of microorganisms
belonging to the genus Aerococcus, Globicatella, Hellcococcus and
Facklamia. We describe the biological properties of individual members
of these genera, their role in the pathology of human and animals. We
present the morphological, physiological, biochemical and molecular
genetic criteria for the identification of these bacteria.
Key words: Aerococcus, Globicatella, Hellcococcus, Facklamia, grampozitivnye cocci, heterogeneity, sequencing, phylogenetic, phenotypic study and identification.
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22-32 |
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| ÏÐÎÒÈÂÎÌÈÊÐÎÁÍÀß ÀÊÒÈÂÍÎÑÒÜ, ÔÀÐÌÀÊÎËÎÃÈ×ÅÑÊÎÅ ÄÅÉÑÒÂÈÅ È ÒÎÊÑÈ×ÍÎÑÒÜ ÏÐÎÑÒÐÀÍÑÒÂÅÍÍÎ-ÐÀÇÂÅÒÂËÅÍÍÛÕ ÏÐÎÈÇÂÎÄÍÛÕ ÔÅÍÎËÀ Ðóäåíêî Ë.Ì., Âîëêîâ À.À. ANTIMICROBIC ACTIVITY, PHARMACOLOGICAL ACTION AND TOXICITY OF THE SPATIALLYBRANCHED OUT DERIVATIVES OF PHENOLUM Rudenko L.M., Volcov A.V. The
analysis of data of the literature devoted to biological activity,
degree of antimicrobic action, to pharmacological effects
and toxicity of phenolic bonds of various structure is carried
out. The prospect of the further scientific researches of
derivative spatially-branched out Phenolums for the purpose of creation
on their basis of effective and moderately toxic
antimicrobic agents is designated.
Keywords: Phenolum, antimicrobic activity, pharmacological effects, acute and chronic toxicity. |
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| ÄÅßʲ ÏÐÎÁËÅÌÈ Ì²ÊÐÎÁ²ÎËÎò×Íί IJÀÃÍÎÑÒÈÊÈ ÅØÅÐÈÕ²ÎÇÓ ² ÊÎ˲ÁÀÊÒÅвÎÇÓ Â ÃÓÌÀÍÍ²É ÒÀ ÂÅÒÅÐÈÍÀÐÍ²É ÌÅÄÈÖÈͲ Áàëóòà ².Ì., Ìàëàí÷óê Ñ.Ã., Ãîëóáêà Î.Â., ̳ç³í Â.Â., Áîíäàð Â.Î., Àëüõóñå³í Ìóñòàôà Àë³ SOME PROBLEMS OF MICROBIOLOGICAL DIAGNOSTICS OF ESHERIKHIOZA AND KOLIBAKTERIOZA ARE IN PRACTICAL AND VETERINARY MEDICINE Baluta I.M., Malanchuk S.G., Golubka O.V., Mizin V.V., Bondar V.A., Al'khuse³n Mustafa Al³ The
microbiological diagnosis state of Esherichiosis and Colibacteriosis in
medicine and veterinary was analysed. The perspective approaches to the
improvement of the laboratory diagnosis of the disease, which are
conditioned by Escherichia coli was market.
Key words. Esherichiosis, Colibacteriosis, microbiological diagnosis. |
30-32 |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| ÂÏËÈ ÌÎÄÈÔ²ÊÎÂÀÍÈÕ ²ÌÓÍÎÌÎÄÓËßÒÎв ÍÀ ÔÓÍÊÖ²ÎÍÀËÜͲ ÂËÀÑÒÈÂÎÑÒ² ˲ÌÔÎÖÈҲ Ðîìàíîâà Î.À., Ìàðòèíîâ À.Â., Âîëÿíñüêèé À.Þ., ²ãóìíîâà Í.²., Ñèäîðåíêî Ò.À., Ñì³ëÿíñüêà Ì.Â., Ïåðåìîò Ñ.Ä., Êàøïóð Í.Â. MODIFIED IMMUNOMODULATORS EFFECT ON FUNCTIONAL PROPERTIES OF LYMPHOCYTES Romanova E.A., Martynov A.V., Volyansky A.Yu., Igumnova N.I., Sydorenko T.A..,Smelyanskaya M.V., Peremot S.D., Kashpur N.V. Influence
of the partly succinylated derivates of interleukin-2 and
thymalin is studied on functional characteristics of lymphocytes
(capacity for proliferation and reaction of receptor apparatus) in
vitro taking into account the initial state of the immune system
(patients with a acute coronary syndrome or healthy examinees),
specific and organ belonging (lymphocytes of peripheral blood of man,
thymus of rats, spleen of mise). The expressed stimulant effect
acylated IL-2 in relation to all types of tested cells is found out. A
conclusion is done about perspective of
the use of the got derivate IL-2 as constituent or independent drug
possessing high immunopotenting properties, after additional researches
in vivo and in vitro. Keywords: lymphocytes, immunomodulation ability,
modified drugs.
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33-36 |
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| ÂËÈ ÍÅÇÁÀËÀÍÑÎÂÀÍί IJªÒÈ ÍÀ ²ÌÓÍÎÃÎÐÌÎÍÀËÜÍÈÉ ÑÒÀÒÓÑ ÙÓв ÇÀ ÓÌΠ²ÌÓͲÇÀÖ²¯ Êó÷ìà ².Þ., Ñèìèðåíêî Ë.Ë., Íèêèò÷åíêî Þ.Â., ²ùåíêî Ò.²., Âîëÿíñüêèé À.Þ., Áîíäàð Ò.Ì. THE EFFECT OF NON-BALANCED NUTRITION ON THE IMMUNOHORMONAL STATE OF RATS UNDER IMMUNIZATION Kuchma I.J., Simirenko L.L., Nikitchenko J.V., IschenkO T.I., Voljanskij A.J., Bondar T.M. Influence
of the maintenance of rats males of Wistar line from 1-month's age
throughout 90 days on a diet unbalanced by animal proteins and vitamins
of an antioxidatic number on specific antibody genesis activity was
investigated. The maintenance of rats on an unbalanced diet
resulted in the formation of an organism hyperthyroid state and was
accompanied by depression of specific antibody genesis activity at
immunization of 3- month's animals by ADT-anatoxin. Results of
immunohormonal
communications analysis in the dynamics of the humoral immune answer
formation are described by means of empirical function of regression
and added by correlation models.
Key words: thyroid hormones, non-balanced nutrition, ADT-anatoxin, rats. |
37-43 |
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| ÏÅÐÑÈÑÒÓÞ×À ÃÅÐÏÅѲÐÓÑÍÀ ²ÍÔÅÊÖ²ß: ÐÎËÜ ÏÐÈ ÑÎÖ²ÀËÜÍÎ ÇÍÀ×ÓÙÈÕ ÇÀÕÂÎÐÞÂÀÍÍßÕ Â ÓÊÐÀ¯Í² Ñì³ëÿíñüêà Ì.Â. THE PERSISTENCE HERPESVIRUS INFECTION: ROLE OF SOCIALLY MEANINGFUL DISEASES IN UKRAINE Smelyanskaya M. The
conducted researches are show the role of viruses of group
of Herpesviridae in the process of pathogenesis socially meaningful
diseases of human (SMD) is ischemic heart
disease, cancer and tuberculosis. Except for the traditional methods of
treatment other approach is offered is a purposeful
fight against persistence viruses. It is shown that
conducting of antiviral therapy in the complex of base measures
at SMD gives a positive effect: success at treatment of
SMD,
and also prevention of relapses.
Key words: herpesviral infection, ischemic heart trouble, cancer, tuberculosis, diagnostics, treatment. |
44-48 |
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| ÔÓÍÊÖÈÎÍÀËÜÍÀß
ÀÊÒÈÂÍÎÑÒÜ ËÈÌÔÎÖÈÒΠ×ÀÑÒÎ ÁÎËÅÞÙÈÕ ÄÅÒÅÉ Ñ ÑÈÍÄÐÎÌÎÌ ËÈÌÔÀÄÅÍÎÏÀÒÈÈ Ïîïîâ Í.Í., Ñàââî À.Í., Ðîìàíîâà Å.À. FUNCTIONAL ACTIVITY OF LYMPHOCYTES OF OFTEN BEING ILL CHILDREN WITH THE SYNDROME OF LYMPHADENOPATHY Popov N.N., Savvo A.N., Romanova E.A. Descriptions
of lymphoid constituent of peripheral blood of children sufferings by
frequent acute respirators infections
(ARI) without and with the syndrome of lymphadenopathy (LAP) are
studied. By characteristic violations of often being ill ARI children
are considerable decline of
stimulation RBTL on PHÀ, to the products by lymphocytes IL-2 and INFγ,
to activity of their nuclear chromatin, to the concentration in the
serum of blood of INFα and INFγ in a period and after the disease.
Increase
the part of Ò- and Â-lymphocytes, bearings markers activated (CD25+)
and actively proliferated (CD71+) cells both in the acute period of
disease and after convalescence, and also overactivity of nuclear
chromatin and capacity for the increased spontaneous products IL-2 by
mononuclears after completion of illness are the
distinctive features of lymphoid part of blood of often being ill
children.
Key words: lymphocytes, acute respirators infections, lymphadenopathy. |
49-53 |
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| ÂÈÄÎÂÎÉ ÑÎÑÒÀ ÌÈÊÐÎÔËÎÐÛ ÌßÃÊÈÕ ÒÊÀÍÅÉ ÏÀÐÀÄÎÍÒÀ Îñîëîä÷åíêî Ò.Ï., Áàéäàëêà È.Ä., Øòèêåð Ë.Ã., Ïóøêàðü Ë. Þ., Ïèëþãèí Ñ.Â. SPECIES OF MICROFLORA OF PERIODONTATUS Osolodchenko T.P., Baydalka I.D., Shtiker L.G., Pushkar L.Y., Pilyugin S.V. In work
the date for microbiological inspection of patiens with periodontatus.
The motley landscape of microflora allocated. Prevalens of en aerobic-
anaerobic microflora. The received results specify in necessity of the
profilactic control from outside the stomatologic.
Key words: microflora, periodontatus, antibioticus |
54-57 |
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| ÖÈÒÎÃÅÍÅÒÈ×Ͳ ÅÔÅÊÒÈ ÂÏËÈÂÓ Á²ÎÒÈ×ÍÈÕ ÒÀ ÀÁ²ÎÒÈ×ÍÈÕ ÔÀÊÒÎв ÍÀ ÄÈÔÒÅвÉÍÈÉ ÒÎÊÑÈÍ Áàáè÷ ª.Ì., Øêîðáàòîâ Þ.Ã., ʳââà Ô.Â., Êàë³í³÷åíêî Ñ.Â., Ïàñþãà Â.Ì., Êîëïàê Ñ.À., Ðèæêîâà Ò.À., Êîâàëåíêî Î.²., Àíòóøåâà Ò.². CYTOGENETIC EFFECTS OF INFLUENCE OF BIOTIC AND ABIOTIC FACTORS ON DIPHTHERIA TOXIN Babych E.M., Shckorbatov Yu.G., Kivva F.V., Kalinichenko S.V., Pasyuga V.M., Kolpak S.A., Ryzhkova T.A., Kovalenko O.I., Antusheva T.I. The
influence of bacterial toxins on genome of buccal epithelium cells was
studied. It was determined, that diphtheria exotoxin had a negative
influence on nuclear apparatus of eukaryotic cells. As a result of this
influence the proper
areas of chromatin lose their metabolic activity. Millimeter waves
irradiation of diphtheria toxin resulted to reduction of the above
mentioned toxin negative effects on
nuclear genome of buccal epithelium cells.
Key words: bacterial toxins, buccal epithelium, millimeter waves. |
58-61 |
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| ÏÀÌßÒÈ
ÈÂÀÍÀ ÈÂÀÍÎÂÈ×À ÌÀÂÐÎÂÀ |
62 |
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