Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| CLINICAL COURSE AND EFFICACY OF TB TREATMENT DURING THE EPIDEMIC OF TUBERCULOSIS IN THE KHARKIV REGION. Lebid L.V., Kireev I.V. Poteyko P.I., Lyashenko A.A., V.S.Krutko., Sokol T.V. The
subject of the study was the clinical course of tuberculosis and the
treatment effectiveness of patients during the TB epidemic in the
Kharkiv region. Hematological toxicity index was defined in 413
patients. The treatment effectiveness was studied in its relation to
the clinical form of tuberculosis, the presence of destruction of lung
tissue, bacterial excretion, as well as the presence of resistance to
TB drugs
Key words: tuberculosis, clinical form, treatment effectiveness, Kharkiv region |
5-12 |
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| ÏÐÎÒÈ̲ÊÐÎÁͲ ÂËÀÑÒÈÂÎÑÒ² ͲÒÐÎÃÅÍÎÂ̲ÑÍÈÕ ÊÎÍÄÅÍÑÎÂÀÍÈÕ ÑÈÑÒÅÌ Ç Ï²ÐÈ̲ÄÈÍÎÂÈÌ ÔÐÀÃÌÅÍÒÎÌ Ùåðáàê Î. Ì., Àíäðåºâà ².Ä., Êàçì³ð÷óê Â. Â., Æóðàâåëü ². Î. THE ANTIBACTERIAL PROPERTIES OF CONDENSED NITROCONTAINING COMPOUNDS WITH THE PYRIMIDIN FRAGMENT (REVIEW) Scherbak O. M., Andreieva I. D., Kazmirchuk V. V., Zhuravel I. O. The review
summarizes the data of domestic and foreign sources concerning
antibacterial properties of condensed heterocyclic compounds of
different groups. The prospect of direct synthesis of condensed
heterocyclic compounds and the study of their antimicrobial activities
in order to develop new antibacterial agents on their basis is founded.
Key words: infectious diseases, condensed nitrocontaining compounds, antibacterial activity |
12-18 |
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| ÐÎÇÏÎÂÑÞÄÆÅÍÍß ÎÑÍÎÂÍÈÕ ÃÅͲ ²ÐÓËÅÍÒÍÎÑÒ² ÑÅÐÅÄ ÏÐÅÄÑÒÀÂÍÈʲ ÐÎÄÓ VIBRIO Ïåòðåíêî Î.Â. THE SPREAD OF THE VIRULENCE KEY GENES AMONG THE REPRESENTATIVES OF THE GENUS VIBRIO Petrenko O. V. Bacterial
DNA floatings, which relate to separate genes recombination as well as
genomic blocks gaining resulted from horizontal transgenesis, underlie
phenotypic and genotypic properties transformations of vibriosis
causative agents. The environmental spread of the vibrios with
different pathogenic potential assists to form vibriosis new causative
agents with various combination of the genes of pathogenicity.
Key words: vibrios, genes of pathogenicity, virulence.
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19-25 |
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| ÏÍÅÂÌÎÖÈÑÒÍÀß ÏÍÅÂÌÎÍÈß: ÈÑÒÎÐÈ×ÅÑÊÈÅ, ÝÏÈÄÅÌÈÎËÎÃÈ×ÅÑÊÈÅ È ÊËÈÍÈÊÎ-ÌÎÐÔÎËÎÃÈ×ÅÑÊÈÅ ÀÑÏÅÊÒÛ Ìàðêîâñêèé Â. Ä., Ïëèòåíü Î. Í., Ìèðîøíè÷åíêî Ì. Ñ., Ìèðîøíè÷åíêî À. À. PNEUMOCYSTIS PNEUMONIA: HISTORICAL, EPIDEMIOLOGICAL, CLINICAL AND MORPHOLOGICAL ASPECTS Markovskiy V. D., Pliten O. N., Myroshnychenko M. S., Myroshnychenko A. A. Pneumocystis
pneumonia is a life-threatening form of pneumonia, which occurs in
people with insufficiency of immune system. In the article is devoted
the data of the literature about historical, epidemiological,
diagnostic, clinical and morphological aspects of pneumocystis
pneumonia. The authors give two own observations from the practice of
pneumocystis pneumonia that was diagnosed in young women using autopsy
material. This article will allow the doctors of practical health care
to pay special attention to the timely prevention, diagnostics and
treatment of this pathology.
Key words: pneumocystis pneumonia, diagnostics, clinical and morphological features |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| MODELS OF AMPHOTERICIN MEMBRANE CHANNEL BASED ON CONCERTED INTERMOLECULAR =C-H…O INTERACTIONS Lisnyak Yu. V. To study
the possibility for amphotericin to form membrane channel via
intermolecular interactions mimicing the association mode of polyene
macrolides in crystal structures we have built two channel models in
vacuo: amphotericin B octamer and hexamer. The octamer model does not
reproduce the concerted weak =C-H…O intermolecular interactions within
the whole aggregate structure and has too large pore diameter. For
hexamer model, the pore diameter is within experimental estimates. The
hexamer model rather well reproduces characteristic features of a
channel with such concerted weak interactions: association mode,
H-bonding pattern within the whole assembly and accessibility of
polyene hydroxyl groups for hydrophyllic interactions in the pore.
Key words: amphotericin, molecular modeling, interaction, membrane channe |
33-37 |
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| THE ROLE OF REPRESENTATIVES IN OPHTHALMIC PATHOLOGY HERPESVIRUS Smelyanskaya MV, Peremot SD, Martynov AV,Volyansky AY, Kashpur NV, Voloshko IV, Moroz MP The goal
was to establish a place of herpesviruses (HSV1, HSV2, HHV6, SMV, VZV,
EBV) in the etiological structure of the eye’s diseases. The study
involved 35 patients diagnosed with recurrent keratitis (15 patients)
and viral uveitis (n = 20). Was carried out virological examination,
including a study using fluorescent antibody scrapings from the cornea
and conjunctiva for the presence of herpesvirus antigen in leukocytes
and determination of the blood antigens of viruses with the calculation
of the fluorescence index (FI). Set of different herpesvirus
persistence in leukocytes of blood in 95% of patients with viral
uveitis and 32% of patients with keratitis. In the each second patient
with viral uveitis (10) detected association of three or more
herpesvirus antigens in blood leukocytes. Most often these associations
are found antigens of viruses EBV, SMV, and HHV6.
Key words: herpes, eye’s diseases, immunofluorescence, etiological structure. |
38-40 |
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| ÑÒÐÓÊÒÓÐÍÛÅ ÄÎÌÈÍÀÍÒÛ ÍÅÂÐÈÒÀ ÒÐÎÉÍÈ×ÍÎÃÎ ÍÅÐÂÀ  ÝÒÈÎÏÀÒÎÃÅÍÅÒÈ×ÅÑÊÎÉ ÊÀÐÒÈÍÅ ÏÐÎËÎÍÃÈÐÎÂÀÍÍÛÕ ÈÍÔÅÊÖÈÎÍÍÎÂÎÑÏÀËÈÒÅËÜÍÛÕ ÏÐÎÇÎÏÀËÃÈÉ Òîðÿíèê È.È. STRUCTURAL DOMINANTS OF THE TRIGEMINAL NERVE’S NEURITIS IN ETYOPATHOGENETIC PICTURE’S PROLONGATIVE INFECTIOUS AND INFLAMMATORY PROSOPALGIA Òîrianik ².². The
morphological analysis’s results of the trigeminal nerve’s fragments
and its node after the experimental infectious and inflammatory
neuritis influence are presented in this work. The examinational
model’s are Chinchilla rabbit’s male of the 2.5-3.0 kg by weight, which
was puted agent on perineural cavity. In experimental results was
adjusted, that the acute form’s of the trigeminal nerve’s neuritis was
obtain. The oedema, inflammatory infiltration, which was includes
lympho-monocytical component’s plasmosytes were became the
morphological evidence. The present signs of the gigantocellula
metamorphosis, hyperchromatosis, basophil granular, typical nuclear
changes (caryorexis, caryopiknosis) was been determined of the specific
damages.
Key words: structural dominants, trigeminal nerve, etyopathogenetic picture, prolongative infectious and inflammatory prosopalgia. |
41-44 |
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| ÀÍÀË²Ç Á²Îղ̲×ÍÎÃÎ ÑÊËÀÄÓ Ô²ÒβÌÓÍÎÊÎÐÅÊÒÎÐÓ «ÀÔËÓÔ²Ò» ÌÅÒÎÄÎÌ ÂÈÑÎÊÎÅÔÅÊÒÈÂÍί вÄÈÍÍί ÕÐÎÌÀÒÎÃÐÀÔ²¯ Íåìÿòèõ Î.Ä. ANALYSIS OF BIOCHEMICAL COMPOSITION OF FITOIMMUNOKORREKTOR "AFLUFIT" BY METHOD OF HIGH-EFFICIENCY LIQUID CHROMATOGRAPHY Nemyatykh Î.D. The
research on development of methodologies of qualitative and
quantitative determination of active and auxiliary substances in
composition of preparation "Aflufit" in form child's syrup and jelly by
method of highefficiency liquid chromatography have been conducted.
Identification and quantitative maintenance of active (chlorogenic,
1,3-dicofeilchinic, derivatives of coffee acid) and auxiliary (sorbic,
maleinic, lemon, apple acids, saccharose, maltose, glucose, fructose,
arabinose) substances have been certained. Worked out methodologies is
simple, highly selective and can be used for control of quality of
medicine.
Êey words: high performance liquid chromatography, analysis, "Aflufit" |
45-50 |
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| ÌÎËÅÊÓËßÐÍÅ ÌÎÄÅËÞÂÀÍÍß ÂÇÀªÌÎÄ²É ÏÐÎÒÈ̲ÊÐÎÁÍÈÕ ÑÏÎËÓÊ Ç ÅËÅÌÅÍÒÀÌÈ Ê˲ÒÈÍÍί ÌÅÌÁÐÀÍÈ: ͲÑÒÀÒÈÍ-ÅÐÃÎÑÒÅÐÈÍÎÂÀ ÌÅÌÁÐÀÍÍÀ ÏÎÐÀ ˳ñíÿê Þ. Â., Ìàðòèíîâ À. Â. MOLECULAR MODELING OF INTERACTIONS OF ANTIMICROBIAL COMPOUNDS WITH CELL MEMBRANE COMPONENTS: NYSTATIN-ERGOSTEROL MEMBRANE PORE Lisnyak Yu.V., Martynov A.V. Model of
nystatin-ergosterol membrane channel has been built by molecular
modeling methods. Peculiarities of molecular structure and
intermolecular interactions of this supramolecular aggregate have been
analyzed. Parameters of our model have been compared with experimental
data. The presented model of nystatin-ergosterol membrane channel can
be incorporated into phospholipid bilayer membrane to serve as a
starting structure in further comprehensive molecular dynamics
simulations of these systems in lipid and aqueous environment.
Êey words: nystatin-ergosterol membrane channel, molecular modeling, supramolecular aggregate |
51-56 |
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| ÂÈÊÎÐÈÑÒÀÍÍß ÍÎÌÎÃÐÀÔ²×ÍÎÃÎ ÌÅÒÎÄÓ Â ÅÒ²ÎËÎò×Í²É ÐÎÇØÈÔÐÎÂÖ² ÀËÅÐò×ÍÎÃÎ ÐÈͲÒÓ Ó Ä²ÒÅÉ Øìóë³÷ Â.Ê., Ïðîõîðåíêî Î.À., Øìóë³÷ Î.Â., Ñòàðóñåâà Â.Â., Öèìáàë Â.Í., Àùåóëîâ Î.Ì., Òåñëåíêî Ò.Î. FEATURES OF ETIOLOGIC SPECTRUM OF ALERGIC RINITY FOR CHILDREN DEPENDING ON SEX AND AGE Shmulich V.K., Prokhorenko A.A., Shmulich O.V., Staruseva V.V., Zimbal V.N., Asheulov .OM., Teslenko T. In this
work there are presented the results of allergy testings of children
suffering from alergic rinity. The aim of this study was the
specification of casually significant allergen depending on sex and
age. Results of testing are processed by a method of the mathematiical
analysis, raised in nomograms according to which, considering the
nosological entity of disease, sex and age of a patient, it is possible
to define causally significant allergen.
Key words: nomographic method, children, etiology, alergic rinity, scarification. |
57-61 |
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| ÄÎÑ˲ÄÆÅÍÍß ÒÅÕÍÎËÎò×ÍÈÕ ÒÀ ̲ÊÐÎÁ²ÎËÎò×ÍÈÕ ÂËÀÑÒÈÂÎÑÒÅÉ ÊвÎÏÎÄвÁÍÅÍί ÐÎÑËÈÍÍί ÑÈÐÎÂÈÍÈ Êîíþõîâ ².Â. ×óºøîâ Â.²., Ñîëäàòîâ Ä.Ï. RESEARCH OF TECHNOLOGICAL AND MICROBIOLOGICAL PROPERTIES OF THE CRYOMILLED MEDICINAL PLANT RAW MATIRIAL Koniukhov I.V., Chueshov V.I., Soldatov D.P. The
technological parameters of the cryomilled plant raw matirial Calendula
flowers, Taraxacum roots, Silybum fruit, Mentha leaves, Menyanthes
grass, Agrimonia grass, Fumaria grass have been determined.
Microbiological cleanness and antimicrobial activity of cryopowders and
input material have been researched. It is established that use of
cryomilling lead to microbiological contamination decrease, cryopowders
of researched medicinal plant raw material can be used in tablets
technology.
Key words: vegetable raw materials, tablets, cryogenic grinding, cryo powder cryo mill, operating characteristics, microbiological properties, antimicrobial activity, hepatic. |
62-66 |
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| ²ÌÓÍÎÁ²ÎËÎò×ÍÀ ÕÀÐÀÊÒÅÐÈÑÒÈÊÀ ÎÊÐÅÌÈÕ ÔÐÀÊÖ²É ÏÐÀÂÖÅÂÎÃÎ ÀÍÀÒÎÊÑÈÍÓ ÄÎ ÒÀ ϲÑËß ÂÏËÈÂÓ ÓËÜÒÐÀÇÂÓÊÎÂÈÕ ÕÂÈËÜ Áàáè÷ ª.Ì., Êàë³í³÷åíêî Ñ.Â., Ðÿáîâ³ë Î.Â., ʳââà Ô.Â., Ðèæêîâà Ò.À., Ñêëÿð Í.²., Êîâàëåíêî Î.²., Ïëóãàòîð Ò.Ì., Åãë³ò Â.Î., Á³ëîçåðñüêèé Â.². IMMUNOBIOLOGICAL CHARACTERISTIC OF TETANUS TOXOID FRACTIONS BEFORE AND AFTER EXPOSURE TO ULTRASONIC WAVES Babych Ye.M., Kalinichenko S.V., Ryabovol E.V., Kivva F.V., Ryzhkova T.A., Sklyar N.I., Kovalenko O.I., L.A., Plugator T.N., Eglit V.A., Bilozerskii V.I. Fractional
composition of industrial tetanus toxoid before and after exposure to
ultrasonic waves was determined with the use of gel filtration
chromatography. It was established, that with the exception of specific
antigenic structures (fraction A), tetanus toxoid contained ballast
proteins (fraction B). Ultrasound treatment of tetanus toxoid resulted
in ballast proteins quantity decrease. Percentage composition of
tetanus toxoid fractions depended on ultrasound treatment conditions.
Key words: tetanus toxoid, chromatography, ultrasound. |
67-69 |
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| ²ÍÄÓÊÖ²ß Ò- ÒÀ Â-Ê˲ÒÈÍÍί ²ÌÓÍÎËÎò×Íί ÏÀÌ’ßÒ² ÇÀ ÂÀÊÖÈÍÀÖ²¯ вÇÍÈÌÈ ÒÈÏÀÌÈ ÂÀÊÖÈÍ Âîëÿíñüêèé À.Þ. THE INDUCTION OF T-AND B-CELLS OF IMMUNE MEMORY DURING THE VACCINATION WITH DIFFERENT TYPES OF VACCINES Volyansky A. Yu. The
dynamics of the generation of T-and B-cell of immunological memory
under the influence of vaccination with different types of vaccines
have been investigated. It was found that the creation of resistant
strained immunity (The adsorbed diphtheria-tetanus toxin with a reduced
amount of antigens, measles vaccine) is associated with a twofold
increase during the first months after inoculation of the amount of TCM
(CCR7 + CD45RA-) - and BM (CD22 + CD72 +) - memory cells in the
peripheral blood. The induction of only memory Tcells (TCM), which is
not accompanied by the formation of memory B cells, does not lead to
the prolonged preservation of immunity.
Key words: vaccination, T-cells and B-cells of immune memory, long-term immunity. |
67-69 |
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