Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÑÓ×ÀÑÍÈÉ ÑÒÀÍ ÐÎÇÐÎÁÊÈ ÒÀ ÇÀÑÒÎÑÓÂÀÍÍß ÏÐÎÁ²ÎÒÈ×ÍÈÕ, ÏÐÅÁ²ÎÒÈ×ÍÈÕ ÒÀ ÑÈÍÁ²ÎÒÈ×ÍÈÕ ÏÐÅÏÀÐÀҲ (îãëÿä ë³òåðàòóðè) Êàë³í³÷åíêî Ñ.Â., Áàáè÷ ª.Ì., Ðèæêîâà Ò.À., Ìàñë³é ².Ã., Êîðîòêèõ Î.Î., Äàí³ë³íà Ñ.Ñ., Ñîëÿí³ê Î.Ã., Øèêîâà Î.À., Ñêëÿð Í.²., Òêà÷ Ë.Ì., Áàëàê À.Ê., ͺìêîâà Ñ.Ì., Äåñÿòíèêîâà Î.Â. THE MODERN STATE OF DEVELOPMENT AND APPLICATION OF PROBIOTICS, PREBIOTICS AND SYNBIOTICS Kalinichenko S.V., Babych E.M., Ryzhkova T.A., Maslii I.G., Korotkykh O.O., Danilina S.S., Solianik O.G., Shykova O.A., Sklyar N.I., Tkach L.N., Balak A. K., Nemkova S.M., Desiatnikova O.V. Mass
uncontrolled use of antibiotics, environmental degradation, large
amount of stress situations cause reduction of adaptive abilities of
human body, activate the sympathetic-adrenal system, which, in turn,
causes the neurohumoral changes due to the imbalance of
neurotransmitters production, affecting specific and nonspecific
resistance of the organism, as well as the microorganisms. According to
WHO data, the number of people with disorders of immune system is
constantly increasing. That leads to exacerbation of chronic diseases,
including those caused by opportunistic pathogens. Thereby, it is very
important to develop appropriate methods for macroorganism’s optimum
microbiocenosis restoring. The review summarizes the scientific data
about composition, mechanisms of action and drug formulations of
probiotics, prebiotics and synbiotics. The probable complications after
taking these drugs are described. The main problems associated with the
production and standardization of probiotic preparations and
perspective directions aimed at the normalization of microbial ecology
are presented in the article.
Key words: microbial ecology, probiotics, prebiotics, synbiotics. |
5-12 |
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| ÌÈÊÐÎÁÈÎËÎÃÈ×ÅÑÊÈÅ ÀÑÏÅÊÒÛ ÑÒÀÔÈËÎÊÎÊÊÎÂÎÉ ÈÍÔÅÊÖÈÈ ÍÀ ÑÎÂÐÅÌÅÍÍÎÌ ÝÒÀÏÅ (ÎÁÇÎÐ ËÈÒÅÐÀÒÓÐÛ) Ïîíîìàðåíêî Ñ. Â. MICROBIOLOGICAL ASPECTS OF STAPHYLOCOCCAL INFECTIONS TODAY Ponomarenko S.V. Overview
summarizes the data of the domestic and foreign literature about the
prevalence and biological properties of S. aureus. S. àureusenzymes of
aggression and pathogenicity factors (capsular polysaccharides,
different extracellular protein substances (hemolysins, leukocidins),
phospholipase, hyaluronidase, fibrinolysin, coagulase etc.) which
disintegrate structural components of connective tissue and eukaryotic
cells are described in terms of improvement and enhancement of
microbiological technologies. Detailed information about the problem of
Staphylococcus aureusmultidrugresistance and mechanisms of methicillin
resistance formation is given. The necessity of targeted
monitoring of the biological propertiesof S. aureusselected clinical
isolates in order to optimize detection of the pathogen aggressiveness
is proved.
Key words: Staphylococcusaureus, biological properties, methicillinresistance |
13-17 |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ ÐÎÁÎÒÈ
(EXPERIMENTAL STUDY) |
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| RESEARCH OF SOPHORA JAPONICA L. FLOWER BUDS VOLATILE COMPOUNDS WITH GAS-CHROMATOGRAPHY/MASS-SPECTROMETRY METHOD Maksiutina N.P., Cholak I.S., Karpiuk U.V. This work
represents the results of the research of essential oil contained in
Sophora japonica L. flower buds volatile compounds collected during the
next stages of their development: green flower buds, formed flower buds
and the beginning of flower buds opening. Essential oil assay content
in Sophora japonica L. flower buds was determined with
hydrodistillation method. Content of essential oil in the raw material
is less than 0,1%. Qualitative composition and assay content of Sophora
japonica L. flower buds essential oil constituents
were determined with chromato-mass
spectrometry method. In consequence of
the research 80 constituents were identified in Sophora japonica L.
flower buds out of which 61 substances are during the green flower buds
and beginning of flower buds opening stages, 66 substances are during
formed flower buds stage. Substances are
represented byaliphatic andcyclic terpenoids, their alcohols and
ketones. Most volatile substances were extracted on the stage of formed
buds.
Keywords: Sophora japonica L., volatile compounds, gas-chromatography/mass-spectrometr
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18-23 |
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| ÐÎÇÐÎÁÊÀ ÒÅÕÍÎËÎò¯ ÒÀ ÔÀÐÌÀÊÎ-ÒÅÕÍÎËÎò×Ͳ ÄÎÑ˲ÄÆÅÍÍß ÍÎÂÈÕ ÊÎÌÁ²ÍÎÂÀÍÈÕ ÀÍÒÈòÏÅÐÒÅÍÇÈÂÍÈÕ ÒÀÁËÅÒÎÊ «Á²ÑÎÏÀ̲Ļ Ñòð³ëåöü Î. Ï., Òðóòàºâ ². Â., Ñòðåëüíèêîâ Ë. Ñ. DEVELOPMENT OF TECHNOLOGIES AND PHARMACO-TECHNOLOGICAL RESEARCH COMBINED ANTIHYPERTENSIVE NEW TABLETS "BISOPAMID" Strilets O. P., Trutaev I. V., Strelnikov L. S. The new
original drug, code-named "Bisopamid" in the form of tablets, are
proposed for the treatment of hypertension. As active ingredients of
the tablets are antihypertensive substances from different
pharmacological groups, namely bisoprolol fumarate (beta-blocker),
lisinopril dihydrate (ACE inhibitor), and indapamide (thiazide
diuretic). Tablets "Bisopamid" using excipients (lactose monohydrate,
potato starch, MCC, calcium stearate) were obtained by direct
compression. The main pharmaco-technological characteristics of the
developed tablets "Bisopamid" were conducted and there were found that
all the investigated technological characteristics meet the
requirements of HFCs.
Key words: hypertension, combined pill, bisoprolol, lisinopril, indapamide, pharmaco-technological properties |
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| ÂÈÇÍÀ×ÅÍÍß ÑÒÀÁ²ËÜÍÎÑÒ² ÒÀ ÒÅÐ̲ÍÓ ÏÐÈÄÀÒÍÎÑÒ² ÌÀDz Ç ÖÈÍÊÎÂÎÞ Ñ²ËËÞ ÊÈÑËÎÒÈ Ã²ÀËÓÐÎÍÎÂί ÒÀ Ò²ÎÒÐÈÀÇÎ˲ÍÎÌ Áåçðóêàâèé ª.À. DETERMINATION OF THE STABILITY AND SHELF LIFE OF OINTMENT WITH ZINC SALT OF HYALURONIC ACID AND THIOTRIAZOLINE Bezrukaviy Y.A. Based on
the results of physical-chemical and microbiological research
investigated the stability and shelf life of ointment with zinc
salt of hyaluronic acid and thiotriazoline. Ointment which stored in
aluminum tubes, during all term of researches met allthe indicators of
drugs QC. Ointment which kept in jars from orange glass did not meet
the indicator "acidic number" in definingof indicators per 24 months of
storage. Was established shelf life of medication with zinc salt of
hyaluronic acid and thiotriazoline - 2 years.
Keywords: ointment, stability, shelf life, zinc salt of hyaluronic acid, thiotriasolin. |
28-33 |
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| ÏÅÐÅÄÓÌÎÂÈ ÂÈÍÈÊÍÅÍÍß ÒÀ ØËßÕÈ ÌÅÄÈÊÀÌÅÍÒÎÇÍί ÊÎÐÅÊÖ²¯ ÑÈÍÄÐÎÌÓ ÅÍÒÅÐÀËÜÍί ÍÅÄÎÑÒÀÒÍÎÑÒ² Ó ÕÂÎÐÈÕ ÍÀ ÃÎÑÒÐÈÉ ÏÀÍÊÐÅÀÒÈÒ Êóíîâñüêèé Â.Â. PREREQUISITES OF ENTERIC FAILURE MEDICATED CORRECTION IN PATIENTS WITH ACUTE PANCREATITIS Kunovsky V.V. On the
example of the 62 patients treatment with acute pancreatitis were
studied and considered the background to the development of enteric
failure syndrome (EFS). By results of research it was argued that in
67,74 % of the patients on the background of peristaltic gastric
contractions contractile capacity duodenal ulcer was acute reduced or
significantly delayed, up to its complete absence in 59,68 % of
patients. On the basis of morphological researches biopsy of the small
intestine mucous membrane shown that on the basis of the EFS in 76% of
patients with acute pancreatitis developing structural disorders in the
anatomical structure of enterocytes. The ways of these violations drug
correction by inclusion in a complex of drug therapy prokinetics and
probiotic Saccharomyces boulardii according to the developed and
approved regimens.
Key words: acute pancreatitis, enteric failure syndrome, motor and evacuation functions of gastrointestinal tract, morphometry, prokinetics, Saccharomyces boulardii. |
34-39 |
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| ÄÎÑ˲ÄÆÅÍÍß Ä²ÓÐÅÒÈ×Íί ÀÊÒÈÂÍÎÑÒ² ÏÎÕ²ÄÍÈÕ 3-ÌÅÒÈË- 7-ÀËʲË-8- ÌÎÐÔÎ˲ÍÎÊÑÀÍÒÈͲ Áàêóìåíêî Ì.Ã. EXPERIMENTAL STUDY OF THE DIURETIC ACTIVITY AMONG 7-SUBSTITUTED- 3-METHYL- 8- MORPHLINOXANTHINES Bakumenko M.G. The
experimental study of influence on functional activity of kidney of 14
compounds among 7-substituted- 3-methyl- 8-morpholinoxanthines
synthesized for the first time and also some mechanisms of this action
were studied. The introduction of studied substances resulted in an
increase of diuresis by 23,8-118,9% (ð<0,05) for 8 hours of
observation in albino rats. The most marked diuretic action was
manifested by compound ¹8 - 3-methyl-7-( -chlorbenstenil-2) 8-
morpholinoxanthines which excelled reference agents hydrochlorthiazide
by 1,8 times. The mechanism of the diuretic effect of compound 1 is
connected not only with a decrease of reabsorption and increase of
excretion of sodium in realization of its pharmacodynemic effects.
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40-43 |
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| ÎÑÍÎÂͲ ÍÀÏÐßÌÊÈ ÑÈÍÒÅÇÓ ÒÀ Á²ÎËÎò×ÍÀ ÀÊÒÈÂͲÑÒÜ ÄÅßÊÈÕ ÔÎÑÔÎÐÎÐÃÀͲ×ÍÈÕ ÑÏÎËÓÊ, ÙÎ Â̲ÙÓÞÒÜ ÔÐÀÃÌÅÍÒÈ ÑÅ×ÎÂÈÍÈ ÒÀ ÒÐÈÕËÎÐÅÒ²ËÀ̲ÄÓ Ãóøèëèê Á.². BASIC SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME PHOSPHOR- CONTATNING ORGANIC COMPOUNDS CONTAINING FRAGMENTS OF UREA AND TRYHLORETILAMID Gushylyk B. Data about
directions of synthesis and use of the phosphororganic compounds in
technics, biology and medicine is presented in the paper. Antimicrobial
activity of 51 phosphororganic salts and Hides containing urine and
threechlor ethylenamide has been studied. Perspective of the
development of effective antimicrobial substances has been determined.
Keywords: organophosphorus agents, antimicrobial activity. |
44-48 |
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