Annals of Mechnikov's Institute 2006 4
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PERSPECTIVES AND DEVELOPMENT PRODUCTION OF BIOTECHNOLOGICAL DRUGS IN UKRAINE
Strelnikov L.S., Strilets O.P., Shcherbak E.V., Chicitkina V.V., Dolgova T.A.
This article presentation the modern situation and perspectives of pharmaceutical biotechnology in the world and the Ukraine. In the article are discussion perspectives applications of biotechnology methods for production the drugs. Advantage these preparations are low cost and dont have any side-effect.

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EXPERIMENTAL APPROACHES TO CREATION OF ENTERAL FORMS OF ANTIDIPHTHERITIC PREPARATIONS
Belozersky V.I., Babich E.M., Volansky Y.L., Krasnopolsky Y.M., Chetinina V.M., Kolokolova O.B., Verezub L.G., Martinov A.V., Zhdamarova L.A., Sklar N.I., Chuyeshov V.I.
The data of study of immogenic properties of somatic antigens of Corynebacterium diphtheria protected by different polymer combinations at different methods of application are presented. More expressed immunogenity of liposomal forms of antigen at introduction per os to experimental animals at background of preliminary parenteral in-troduction of this preparation is demonstrated. The conclusion about the perspective of improvement of immunization shemes with utilization of effective doses and optimal intervals between the introduction of preparations.
Key words: liposomal and modificated forms of antigens; Corynebacterium diphtheriae, revaccination, ground-immunity, humoral immnity, antibodies.
 
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THE INFLUENCE OF ADT-ANATOXIN ON GLUCOCORTICOID STATUS OF RATS OF DIFFERENT AGE
Volyanskiy A.Y.
We examined the age-specific glucocorticoid status characteristics of intact male rats line Wistar aged 3 an 30 months during the immunization with ADT-anatoxin. The age-specific features of glucocorticoid function GG ACS functional state and the age-related and specific differences of anti-diptheria and anti-tetanus antibody genesis during the antitoxic immune response development process were identified. The empirical mathematical models of body glucocorticoid status changes in the dynamics of formation process of the antitoxic immune response are received depending on term after immunization and age of animals.
Key words: corticosterone, rats, immunization, antibody genesis, ADT-anatoxin.

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TECHNOLOGY OF CREATION OF LIQUID PROBIOTIC FROM AEROCOCCI
Rijenko S.A., Kremenchutsky G.N., Bredichina M.O., Diklenko T.V., Drobot O.V., Stepansky D.A., Chilko L.V., Valchuk S.I., Urgel L.G., Kondratiev A.U., Koshevaya I.P.
The dynamics of growth of culture of production culture of A.vrdans N 167 on different nourishing environments and an optimum nourishing environment is select for the receipt of liquid form of probiotics A-bacterinum. Possibility of constructing of liquid forms of probiotics is experimentally well-proven taking into account the biochemical aspects of metabolism of probiotics cultures and by the observance of principles and requirements FAO/WHO. On the basis of the received data the basic technological scheme of manufacture of the liquid form of a probiotic is developed A-bacterinum.

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PERSISTENT HERPESVIRUSES AS POTENTIAL TRIGGER-FACTOR OF SOME SOMATIC DISEASES
Smelyanskaya M.V., Peremot S.D., Martynov A.V.
Obtained results shown that in humans organism, especially with chronic somatic pathology, were presented persistent viruses of herpes group in one or more organs with big probability. Presence persistent viruses of herpes group in one or more humans organs can start mechanism of reactivation of persistent infection, caused by herpes virus with involved in infectious process other not herpes group viruses. Besides after infected by herpes virus of host organism the related virus from other group are possible caused of they exaltation action.
Key words: herpesviruses, persistence, somatic patology.
 

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CHLORINE DIOXIDE AS AN AGENT OF PROPHYLAXIS OF NOSOCOMIAL INFECTION
Mokienko A. V., Petrenko N. F., Gozhenko A. I., Ponomarenko A.N.
In work some given literatures on interrelation microbial contaminations of water and flares of nosocomial infection are submitted. The necessity of a padding decontamination of water submitted in hospitals is proved. The assumption of an opportunity of application for this purpose of chlorine dioxide as high performance desinfectant is stated.
Key words: chlorine dioxide, desinfection of water, nosocomial infection, prophylaxis
 

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USING OF CLONING METHODS FOR DISCOVERING THE INFLUENCE OF ENDOGERMETICS ACTION ON STROMA CELLS (IN VITRO)
Astahova V.S., Panchenko L.M.
The results of investigation of cytotoxic influence of materials for root canals feeling by cells-cultivating method are described in the article.
Key words: cells-cultivating method, fibroblasts, cytotoxic fluence, materials for root canals feeling.
 
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DEVELOPMENT OF INDIVIDUAL CHARTS OF APPLICATION OF ANTIBACTERIAL PREPARATIONS AT INFLAMMATORY PATHOLOGIES OF SKIN AND MUCOUS MEMBRANES FOR DOGS ON BASIS OF RESULTS OF STUDY OF PROPERTIES OF SELECTED MIKROFLORY
Obuchovskaya O.V., Stegniy B.T., Keleberda N.I., Glebova K.V.
During conducting of bacteriological study of pathological material from dogs with different pathologies (dermatitises, vaginits, postits, conjunctivitises, otitides and stomatits) isolated and studied 205 cultures of microorganisms. It is set that gram+ cocci (representatives of births of Staphylococcus, Streptococcus and Micrococcus) and enterobakterys (representatives of Proteus, Citrobacter and Serratia) have most etiologic value, which in 81,46 % cases selected in composition bacterial associations. The sensitiveness of the selected cultures is studied to the basic groups of antibiotics. Methodical approaches are certain to development of individual charts of treatment

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