Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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NEW APPROACH TO DESIGN AND SYNTHESIS OF THERAPEUTIC AND PREVENTIVE DRUGS, TAKING INTO ACCOUNT INTERSPECIES POLYMORPHISM OF RECEPTORS (METHOD OF PRECISION PARTIAL MODIFICATION) Martynov A.V., Smelyanskaya M.V., Peremot S.D. In the
article are presented new theory of drug’s development with used of
unclear and selfassembled structures – partial modified biopolymers.
Also was shown perspectives in gene therapy developments and new design
of actual vaccines with used principle of unclear structures .
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5-15 |
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| ÈÌÌÓÍÎÐÅÃÓËßÒÎÐÍÛÅ ÂÎÇÌÎÆÍÎÑÒÈ ËÈÌÔÎÈÄÍÛÕ ÈÌÈÅËÎÈÄÍÛÕ ÊËÅÒÎÊ Ðîìàíîâà Å.À., Ïîïîâ Í.Í. IMMUNOREGULATING POSSIBILITIES OF LYMPHOID AND MIELOID CELLS Romanova E.A., Popov N.N. The basic
immunological aspects of hemopoietic and lymphoid cell transplantation
in therapeutic and oncologic practice are outlined. Possibilities of
their separate and joint application come into question with a
regeneration and corrective purpose as facilities with powerful
polyregulating potential.
Key words: lymphocytes, hemopoietic cells, transplantation, regulation. |
16-24 |
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| ÑÒÓϲÍÜ Ç̲ÍÈ Á²ÎËÎò×ÍÈÕ ÂËÀÑÒÈÂÎÑÒÅÉ E.COLI, K.PNEUMONIAE ÒÀ P.AERUGINOSAE Ï²Ä ÂÏËÈÂÎÌ ÅÊÇÎÒÎÊÑÈÍÓ C.DIPHTHERIAE Áàáè÷ ª.Ì., Êàë³í³÷åíêî Ñ.Â., Ðèæêîâà Ò.À. THE CHANGES OF THE BIOLOGICAL PROPERTIES OF E.COLI, K.PNEUMONIAE AND AERUGINOSAE FALLING UNDER INFLUENCE OF C.DIPHTHERIAE EXOTOXIN Babych E.M., Kalinichenko S.V., Ryzhkova T.A. Influence
of different doses of diphtheria exotoxin on growth kinetic, antibiotic
resistance, adhesive and anticomplementary activity of gram-negative
bacteria was studied. It was determined that adhesive activity didn’t
change but anticomplementary activity was 1,26-1,52 times less. Growth
kinetic of gram-negative bacteria increased for certain in 1,7-2,8
times (p<0,05) after 0,1 ml of diphtheria toxin had been added in
1,0 ml of the nutrient medium; influence of lager dose of exotoxin (0,3
ml of exotoxin in 1,0 of the nutrient medium) resulted to growth
kinetic depression in 2,0-3,4 times (p<0,05).
Antibiotic sensibility decreased on average in 1,2-1,4 times independently of the exotoxin dose. Key words: diphtheria exotoxin, growth kinetic, antibiotic resistancenegative bacteria.
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25-29 |
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| ÂËÈßÍÈÅ IVIG-ÒÅÐÀÏÈÈ ÍÀ ÈÌÌÓÍÎ-ÏÀÒÎÃÅÍÅÒÈ×ÅÑÊÈÅ ÔÀÊÒÎÐÛ ÍÅÊÐÎÇÀ ÍÀÄÃÎÐÒÀÍÍÈÊÀ Ïîïîâ Í.Í., Ñàâ÷åíêî À.Â., Ðîìàíîâà Å.À. IVIG-THERAPY INFLUENCE TO THE IMMUNOPATOGINETIC FACTORS EPIGLOTTIS NECROSIS
The influence of IVIG-therapy for clinical
course of disease and immune indicators 23 patients with necrosis form
acute epiglottitis was searched. It was determined that this therapy
renders clinically important effect and positive influence for immune
processes, which play famous pathogenetic part in the development of
epiglottis necrosis. By influence of IVIGtherapy the producing activity
of proinflammatory agent descends, the content of micro- and middle
molecular circularN.N. Popov, A.V. Savchenko, E.A. Romanova immune complexes, collagen and elastin autoantibodyes reduces. Key words: epiglottitis, immunity, epiglottis necrosis. |
30-35 |
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| ÂÈÊÎÐÈÑÒÀÍÍß ÑÒÈÌÓËßÒÎв ÐÎÑÒÓ Ì²ÊÐÎÎÐÃÀͲÇ̲ ÄËß ÍÀÊÎÏÈ×ÅÍÍß Á²ÎÌÀÑÈ Áàòðàê Î.À., ×óïðèíîâà Ñ.²., Çàâàäà Í. Ï., Ðÿáîâà ².Ñ. USE OF GROWTH FACTORS OF MICROORGANISMS FOR ESCALATING A BIOMASS Batrak E. A., Chuprinova S.I., Zavada N. P., Rjabova I.S., Influence
of growth factors of microorganisms (enhancers) on occurrence of the
first colonies and on increase in a biomass of microbic cells is
studied. It is investigated, that increase qualities of microorganisms
considerably increase on nutrient mediums with addition enhancers in
comparison with standards medium. Concentration enhancers slightly
Influences speed of increase in a form make colony of microorganisms
for the certain interval of time.
Key words: microorganisms, medium, enhancers |
36-38 |
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| ÐÀÇÐÀÁÎÒÊÀ ÊÎÌÏÎÇÈÖÈÉ ÏÐÎÒÈÂÎÌÈÊÐÎÁÍÛÕ ÑÐÅÄÑÒÂ Ñ ÏÎÂÛØÅÍÍÎÉ ÑÏÅÖÈÔÈ×ÅÑÊÎÉ ÀÊÒÈÂÍÎÑÒÜÞ Êàçìèð÷óê Â.Â., Áåëîêîíü È. Ô., Åâñþêîâà Â. Þ., Øóëüãà Í. Í., Ïîâîëîêèíà È. Â., Þõèìåíêî Â. È., Âîëÿíñêàÿ Í. À., Ðàä÷åíêî Å. À. WORKING COMPOSITIONS ANTIMICROBIAL TOOL WITH SPECIFICOL SUPERACTIVITY Kazmirchuk V.V., Bilocon I.F., Evsukova V.Y., Shulga N.N., Povolokina I. V., Yhimenko V.I., Volyanska N.A., Radchenko E.A. The
optimum antimicrobial combined compositions for treatment of
contagion’s microbial of an aetiology are developed, the structure of
auxiliary materials influencing rising of specific action of awake
components picks up.
Key-words: norfloõacin, ampicillin, polidekanit, specifical activity composition |
39-42 |
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| ÈÌÌÓÍÎËÎÃÈ×ÅÑÊÀß
ÐÅÀÊÒÈÂÍÎÑÒÜ ÁÎËÜÍÛÕ, ÎÏÅÐÈÐÎÂÀÍÍÛÕ ÏÎ ÏÎÂÎÄÓ ÒÓÁÅÐÊÓËÅÇÀ ËÅÃÊÈÕ, Â
ÇÀÂÈÑÈÌÎÑÒÈ ÎÒ ÑÎÑÒÎßÍÈß ÑÎÅÄÈÍÈÒÅËÜÍÎÉ ÒÊÀÍÈ Ñóõàíîâà Ë.À. IMMUNOLOGICAL REACTIVITY OF THE PATIENTS UNDERGONE THE SURGERY FOR PULMONARY TUBERCULOSIS DEPENDING ON THE STATE OF CONNECTIVE TISSUE Suhanova L. A. The
carried stady of the connective tissue state in 50 patients undergone
the pulmonary tuberculosis revealed that more than a half (58%)
demonstrated the signs of connective tissue dysplasia (CTD) of lungs
and of all organism. All observed patients got the pre- and
postoperative changes in immunological reactivity that is in conformity
with the literature data. Nevertheless, the patients with pulmonary TB
with x-ray and phenotype signs of CTD (compared to the individuals with
absent CTD signs) demonstrated the more T-lymphocytes number that is an
evidence of the strained cellular immunity as well as the higher level
of the pulmonary and bronchial antigene, complement consumption before
and after surgery and bronchial antigen complement consuption after
operationthat reflects the humoral immune activity. The pulmonary CTD
does not influence eesentially on the immunological reactivity of the
organism.
Key words: pulmonary tuberculosis, immunological reactivity, connective tissue dysplasia (CTD) of lungs. |
43-45 |
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| ÂËÀÄÈÌÈÐ ÏÀÂËÎÂÈ× ÁÎÁÈÍ - ÈÇÂÅÑÒÍÛÉ ÍÀ ÓÊÐÀÈÍÅ ÂÐÀ×, ÎÁÙÅÑÒÂÅÍÍÛÉ ÄÅßÒÅËÜ ÕÀÐÜÊÎÂÑÊÎÃÎ ÌÅÄÈÖÈÍÑÊÎÃÎ ÎÁÙÅÑÒÂÀ. Áîáèíà È.Â., Áîáèí Â.Â. VLADIMIR PAVLOVICH BOBIN IS PROMINENT UKRAINIAN DOCTOR, PUBLICMAN OF KHARKOV MEDICAL SOCIETY. Bobbin I.V., Bobin V.V. In memory of Vladimir Pavlovich Bobin - prominent Ukrainian doctor, publicman of kharkov medical society. Historical review.
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46-49 |
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