Annals of Mechnikov's Institute 2007 4
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Contents)



C. (P.)


(Editorial Board)

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(Contents)

2-4

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NEW APPROACH TO DESIGN AND SYNTHESIS OF THERAPEUTIC AND PREVENTIVE DRUGS, TAKING INTO ACCOUNT INTERSPECIES POLYMORPHISM OF RECEPTORS (METHOD OF PRECISION PARTIAL MODIFICATION)
Martynov A.V., Smelyanskaya M.V., Peremot S.D.
In the article are presented new theory of drugs development with used of unclear and selfassembled structures partial modified biopolymers. Also was shown perspectives in gene therapy developments and new design of actual vaccines with used principle of unclear structures .

5-15

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IMMUNOREGULATING POSSIBILITIES OF LYMPHOID AND MIELOID CELLS
Romanova E.A., Popov N.N.
The basic immunological aspects of hemopoietic and lymphoid cell transplantation in therapeutic and oncologic practice are outlined. Possibilities of their separate and joint application come into question with a regeneration and corrective purpose as facilities with powerful polyregulating potential.
Key words: lymphocytes, hemopoietic cells, transplantation, regulation.
 
16-24

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ϲ ̲ ò E.COLI, K.PNEUMONIAE P.AERUGINOSAE ϲ C.DIPHTHERIAE
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THE CHANGES OF THE BIOLOGICAL PROPERTIES OF E.COLI, K.PNEUMONIAE AND AERUGINOSAE FALLING UNDER INFLUENCE OF C.DIPHTHERIAE EXOTOXIN
Babych E.M., Kalinichenko S.V., Ryzhkova T.A.
Influence of different doses of diphtheria exotoxin on growth kinetic, antibiotic resistance, adhesive and anticomplementary activity of gram-negative bacteria was studied. It was determined that adhesive activity didnt change but anticomplementary activity was 1,26-1,52 times less. Growth kinetic of gram-negative bacteria increased for certain in 1,7-2,8 times (p<0,05) after 0,1 ml of diphtheria toxin had been added in 1,0 ml of the nutrient medium; influence of lager dose of exotoxin (0,3 ml of exotoxin in 1,0 of the nutrient medium) resulted to growth kinetic depression in 2,0-3,4 times (p<0,05).
Antibiotic sensibility decreased on average in 1,2-1,4 times independently of the exotoxin dose.
Key words: diphtheria exotoxin, growth kinetic, antibiotic resistancenegative bacteria.

25-29

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IVIG- -
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IVIG-THERAPY INFLUENCE TO THE IMMUNOPATOGINETIC FACTORS EPIGLOTTIS NECROSIS
N.N. Popov, A.V. Savchenko, E.A. Romanova
The influence of IVIG-therapy for clinical course of disease and immune indicators 23 patients with necrosis form acute epiglottitis was searched. It was determined that this therapy renders clinically important effect and positive influence for immune processes, which play famous pathogenetic part in the development of epiglottis necrosis. By influence of IVIGtherapy the producing activity of proinflammatory agent descends, the content of micro- and middle molecular circular
immune complexes, collagen and elastin autoantibodyes reduces.
Key words: epiglottitis, immunity, epiglottis necrosis.


30-35

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USE OF GROWTH FACTORS OF MICROORGANISMS FOR ESCALATING A BIOMASS
Batrak E. A., Chuprinova S.I., Zavada N. P., Rjabova I.S.,
Influence of growth factors of microorganisms (enhancers) on occurrence of the first colonies and on increase in a biomass of microbic cells is studied. It is investigated, that increase qualities of microorganisms considerably increase on nutrient mediums with addition enhancers in comparison with standards medium. Concentration enhancers slightly Influences speed of increase in a form make colony of microorganisms for the certain interval of time.
Key words: microorganisms, medium, enhancers

36-38

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WORKING COMPOSITIONS ANTIMICROBIAL TOOL WITH SPECIFICOL SUPERACTIVITY
Kazmirchuk V.V., Bilocon I.F., Evsukova V.Y., Shulga N.N., Povolokina I. V., Yhimenko V.I., Volyanska N.A., Radchenko E.A.
The optimum antimicrobial combined compositions for treatment of contagions microbial of an aetiology are developed, the structure of auxiliary materials influencing rising of specific action of awake components picks up.
Key-words: norfloacin, ampicillin, polidekanit, specifical activity composition
 

39-42

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IMMUNOLOGICAL REACTIVITY OF THE PATIENTS UNDERGONE THE SURGERY FOR PULMONARY TUBERCULOSIS DEPENDING ON THE STATE OF CONNECTIVE TISSUE
Suhanova L. A.
The carried stady of the connective tissue state in 50 patients undergone the pulmonary tuberculosis revealed that more than a half (58%) demonstrated the signs of connective tissue dysplasia (CTD) of lungs and of all organism. All observed patients got the pre- and postoperative changes in immunological reactivity that is in conformity with the literature data. Nevertheless, the patients with pulmonary TB with x-ray and phenotype signs of CTD (compared to the individuals with absent CTD signs) demonstrated the more T-lymphocytes number that is an evidence of the strained cellular immunity as well as the higher level of the pulmonary and bronchial antigene, complement consumption before and after surgery and bronchial antigen complement consuption after operationthat reflects the humoral immune activity. The pulmonary CTD does not influence eesentially on the immunological reactivity of the organism.
Key words: pulmonary tuberculosis, immunological reactivity, connective tissue dysplasia (CTD) of lungs.
 
43-45

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VLADIMIR PAVLOVICH BOBIN IS PROMINENT UKRAINIAN DOCTOR, PUBLICMAN OF KHARKOV MEDICAL SOCIETY.
Bobbin I.V., Bobin V.V.
In memory of Vladimir Pavlovich Bobin - prominent Ukrainian doctor, publicman of kharkov medical society. Historical review.
46-49

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