Ç̲ÑÒ (Contents)
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÅϲÄÅ̲ÎËÎò×Ͳ ÒÀ ̲ÊÐÎÁ²ÎËÎò×Ͳ ÀÑÏÅÊÒÈ ²ªÐÑÈͲÎDz Ïîë³ùóê Í. Ì. EPIDEMIOLOGICAL AND MICROBIOLOGICAL ASPECTS OF IERSINEOSIS Polishchuk O.O. In the
assay there are new results of research in the antigen
genetic structure and biological properties
of iersineosis and pseudotuberculesis
agents presented as well as characteristics
of modern methodology in laboratory diagnostic
and sensitivity of iersinies towards antimicrobial drugs. There are
also innovative view on epidemiological aspects of
circulation and ability of selfpreservation of
these microorganisms in the environment described. In the
parallel there is a research data
presented along with statistical assay as
for prevalence of iersinia in Ukraine
as well as worldwide. According to
sanitaryepidemiological service statistical data results inUkraine and
official literature sources we can make a conclusion about
deficiencies in principals of iersiniosis
infection revelation in our country. This demands an improvement in
bacteriological methods of investigation and research of modern
technologies in diagnostics of iersiniosis.
Key words: iersinia, biological properties, the antigen genetic structure, epidemiological, microbiological, diagnostics iersineosis |
5-8 |
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| AÑÓÁÊËÈÍÈ×ÅÑÊÈÅ ÍÀÐÓØÅÍÈß ÔÓÍÊÖÈÈ ÙÈÒÎÂÈÄÍÎÉ ÆÅËÅÇÛ Áîíäàðü Ò.Í. SUBCLINICAL DYSFUNCTIOE OF A THYROID GLAND Bondar T.N. Data
populations researches about prevalence subclinical hypo-and
hyperthyroidism, and also the factors
raising probability of their occurrence are presented. Dataabout
potential risk of subclinical hypo-and
hyperthyroidism are discussed.
Key words: thyroid gland, subclinical dysfunction, potential risk. |
9-13 |
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| ÐÅÂÌÀÒίÄÍÈÉ ÀÐÒÐÈÒ ÒÀ ²ÐÓÑ ÅÏØÒÅÉÍ-ÁÀÐÐ Ãð³øèíà Î.². RHEUMATOID ARTHRITIS AND EPSTEIN-BARR VIRUS Grishyna O.I. Recent
publications on the potential relationship between Epstein-Barr
virus (EBV) and rheumatoid arthritis were
analyzed. The results suggest that the
infection/reactivation of the virus as
a consequence of defects in cellular immunity or drug
treatment. Evidence points to EVB that
could act as a trigger in
genetically susceptible hosts.
Key words: rheumatoid arthritis, Epstein-Barr virus, pathogenesis, immunity.
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14-18 |
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| GENERAL CHARACTERISTIC OF THE METHODS FOR DETECTION OF DIPHTHERIA TOXIN Babych E.M., Ryzhkova T.A., Kalinichenko S.V., Sklyar N.I. The
detection of toxigenicity among Corynebacterium
diphtheriae strains is the most
important test for the microbiological
diagnosis of diphtheria. Therefore, we describe
the moderately sensitive phenotypic (in
vitro) assays for exotoxin detection
(Elek test, flocculation test) and more
sensitive ones (agglutination assays, enzyme
immunoassay, immunochromatographic strip test,
immunoblotting, tissue culture tests), as
well as genotypic methods, based upon
polymerase chain reaction and bioassays
(in vivo), which have always been
regarded as the “gold standard”
tests for toxigenicity detection.
Key words: Corynebacterium diphtheriae, diphtheria toxin, toxigenicity, laboratory tests. |
19-21 |
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| THE ROLE OF HERPESVIRUSES I N THE DEVELOPME NT OF CORON ARY HEART DISEASE COMPLICATION S Peremot S.D., Smelyanskaya M.V., Martynov A.V., Peremot J.A. The
research results of CMV and HSV influence on CHD course and
acute myocardial infarction in particular, of
complication developments and outcomes are given inthis article. It is
defined that 48, 5 % of patients with AMI, 22,7 % of patients with
unstable angina and 12,8 % of patients with stable
angina have CMV and HSV
association. The increase
of general cholesterol level, of atherogenity index and the decrease of
HDL level are detected in herpesvirus infected patients with AMI
in comparison with uninfected patients. Heart rhythm
disturbances, thromboembolisms and recurrent
infarction development are observed 1,5-2 times
as often.
Keywords: herpesviruses, coronary heart disease |
22-25 |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| ÏÐÎÄÓÊÖÈß ÈÍÒÅÐÔÅÐÎÍÎÂ Ó ÁÎËÜÍÛÕ ÐÅÂÌÀÒÎÈÄÍÛÌ ÀÐÒÐÈÒÎÌ Ñ ÏÐÈÇÍÀÊÀÌÈ ÏÅÐÅÍÅÑÅÍÍÎÉ ÈÍÔÅÊÖÈÈ ÂÈÐÓÑÀ ÝÏØÒÅÉÍ-ÁÀÐÐ Äûêóí È. ß., Ìåíêóñ Å. Â., Æìóðêîâà Â. Â., Ìóðàäÿí Î. Â. INTERFERON PRODUCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS AND EBV INFECTION SIGNS Dykun I. Ya., Menkus O. V., Zhmurkova V. V, Ìuradyan Î. V. Aim of
research: to examine the interferon α (INF-α) and interferon
γ (INF-γ) contents in synovial
fluid (SF) in patients with rheumatoid
arthritis (RA) depending on Epstein-Barr
virus (EBV) infection signs. It was
found that RA patients with EBV
infection signs have had higher disease
activity and significantly higher contents
of INF-α in SF while INF-γ levels
did not differ comparing to RA
patients without EBV infection signs. Positive
correlation was shown between INF-α contents, ESR level and swollen
joint count as well.
Key words: rheumatoid arthritis, Epstein-Barr virus, interferon alfa, interferon gamma. |
26-29 |
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| ÂËÈßÍÈÅ ÍÅÑÁÀËÀÍÑÈÐÎÂÀÍÍÎÉ ÄÈÅÒÛ ÍÀ ÑÎÑÒÎßÍÈÅ ÏÐÎÎÊÑÈÄÀÍÒÍÎ- ÀÍÒÈÎÊÑÈÄÀÍÒÍÎÉ ÑÈÑÒÅÌÛ ÊÐÎÂÈ ÊÐÛÑ ÏÐÈ ÈÌÌÓÍÈÇÀÖÈÈ ÀÄÑ-ÀÍÀÒÎÊÑÈÍÎÌ Âîëÿíñêèé À. Þ., Íèêèò÷åíêî Þ.Â., Êó÷ìà È.Þ., Ñèìèðåíêî Ë.Ë. THE EFFECT OF NON-BALANCED NUTRITION ON THE STATE OF PROOXIDANTANTIOXIDANT SYSTEM IN BLOOD OF RATS UNDER ADT-IMMUNIZATION Volyanskiy A.Yu., Qikitchenko Yu.V., Kuchma I.Yu., Simirenko L.L. The effect
of non-balanced on animal proteins and antioxidant vitamins nutrition
on the activity of the prooxidant-antioxidant blood system in the
process of immunization anatoxins of ADT-vaccine on 3-month old Wistar
line rats was studied. The content
of lipid hydroperoxides was increased and reliability of
the enzymes of the antioxidant system was reduced. Both of these
processes had resulted in the slowing
of changes of glutathione peroxidase
activity.The activity of glutathione peroxidase
of the blood serum of the treated rats increased on the 7 th - 21 st
days of the experiment in the process of the forming of
humoral immune response to diphteria and
tetanus anatoxins of ADT-vaccine.
Key words: non-balanced nutrition, prooxidantantioxidant balance, ADT-anatoxin, rats. |
30-34 |
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| ÐÅÇÓËÜÒÀÒÛ ÑÅÐÎËÎÃÈ×ÅÑÊÎÃÎ ÌÎÍÈÒÎÐÈÍÃÀ ÈÍÔÈÖÈÐÎÂÀÍÍÎÑÒÈ HHV-6 Ó ÁÎËÜÍÛÕ ÎÑÒÐÛÌ È ÕÐÎÍÈ×ÅÑÊÈÌ ËÀÐÈÍÃÈÒÎÌ Ïîïîâà Í.Ã. THE RESULTS OF SEROLOGICAL MONITORING OF HUMAN HERPESVIRUS TYPE 6 INFECTIOUS IN THE PATIENTS WITH ACUTE ATN CHRONICAL LARYNGITIS Popova N.G. The
analysis is given of literature
date and results of serological monitoring to human
herpesvirus type 6 are presented. It was
established that high infectious of to
human herpesvirus type 6 (52,9±5,0 %) in patientswith acute and chronic
laryngitis.
Key words: human herpesvirus type 6, laryngitis, infectious. |
35-37 |
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| ÊËÈÍÈÊÎ-ÈÌÌÓÍÎËÎÃÈ×ÅÑÊÈÉ ÝÔÔÅÊÒ ÕËÎÐÎÔÈËËÈÏÒÀ ÏÐÈ ÃÍÎÉÍÎÌ ÂÅÐÕÍÅ×ÅËÞÑÒÍÎÌ ÑÈÍÓÑÈÒÅ Ó ÁÎËÜÍÛÕ ÑÀÕÀÐÍÛÌ ÄÈÀÁÅÒÎÌ Îãíèâåíêî Å.Â., Ïîïîâ Í.Í., Ðîìàíîâà Å.À., Ôèëàòîâà È.Â. EFFECT OF
CHLOROPHYLLIPTUM OF CLINICAL AND IMMUNITY COURSE IN PURULENT
RHINOSINUSITIS PATIENTS SUFFERING FROM INSULAR DIABETES The
efficiency of administration of chlorophylliptum as an immunomodulator
in treatment in purulent rhinosinusitis patients
suffering from insular diabetes has been investigated. It has been
established that inclusion of the chlorophylliptum into the complex
treatment of the patients promptly raises the fphagocytic
fnd biocidic activity of the phagocyticcells, opsonizing
properties of serum, raises of affinity of the antibodies
produced in the patients, normalization the content of the basic
antibody of serum.
Key words: chlorophylliptum, immunity, sinusitis. |
38-44 |
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| ÊËÈÍÈÊÎ-ÌÈÊÐÎÁÈÎËÎÃÈ×ÅÑÊÈÅ ÀÑÏÅÊÒÛ È ËÅ×ÅÁÍÛÅ ÌÅÐÎÏÐÈßÒÈß ÏÐÈ ÃÍÎÉÍÎ-ÄÅÑÒÐÓÊÒÈÂÍÛÕ ÏÐÎÖÅÑÑÀÕ ËÅÃÊÈÕ Áèðþêîâà Ñ.Â., Áàêóìåíêî À.Â., Äüÿ÷åíêî Â.Ô., ßãíþê Þ.À., Ìàðþùåíêî À.Ì. MICROBIOLOGICAL ASPECTS AND SURGICAL MEDICAL MEASURES OF PURULENTDESTRUCTIVE DISEASES OF LUNGS Birukova S.V., Bacumenko A.V., Dyachenko V.F., Yagnuk Yu.A., Maruchenko A.M. Microbiological
aspects and surgical medical measures of purulent-destructive
diseases of lungs are discussed this
article. The study of microbiological
spectrum of these diseases facilitates
conducting of adequate therapy. Domestic antiseptic
«Dekasan», possessing an expressive bactericidal action,
is widely used at catchment of abscess
and pleura pectoral cavity for local sanation.
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45-48 |
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| ÐÅÍÒÃÅÍÎÃÐÀÔ²×ÍÅ
ÄÎÑ˲ÄÆÅÍÍß ÏÐÎ̲ÆÍÈÕ ÏÐÎÄÓÊҲ ÐÅÀÊÖ²¯ ÂÇÀªÌÎIJ¯ ÁÓÐØÒÈÍÎÂÎÃÎ
ÀÍòÄÐÈÄÓ ÒÀ β-ÖÈÊËÎÄÅÊÑÒÐÈÍÓ Ó ÂÎÄÍÎÌÓ ÑÅÐÅÄÎÂÈÙ² Ìàðòèíîâ À.Â., Áàóìåð Â.Ì. , ˳ñíÿê Þ.Â. X-RAY ANALYSIS OF INTERMEDIATES OF SUCCINIC ANHYDRATE INTERACTION WITH β-CYCLODEXTRIN IN WATER Martynov A.V., Baumer V.N., Lisnyak Yu.V. The
peculiarities of interaction of succinic anhydrate with β-cyclodextrin
(β-CD) in water are discussed in thepaper. Crystal intermediates
isolated at different stages of the reaction have been studied by X-ray
analysis. X-ray analysis of the samples of single crystals and crystal
powders reveals both β-CD inclusion complex with succinic acid and free
succinic acid in reaction media, and thus confirms that hydrolysis of
succinic anhydratebeing included in β-CD is one of the reaction path.
Key words: succinic anhydrate, β-cyclodextrin, X-ray analysis. |
49-54 |
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| ÑÒÓϲÍÜ ÏÐÎÒÈ̲ÊÐÎÁÍί IJ¯ ÍÎÂÈÕ ×ÅÒÂÅÐÒÈÍÍÈÕ ÏÎÕ²ÄÍÈÕ ÑÎËÅÉ ÑÒÈÐÈËÕ²ÍÎË²Í²Þ Âîëÿíñüêèé À.Þ. ANTIMICROBIAL ACTIVITY NEW 4-ED DERIVATEVE SALTS OF QUINOLINIUM Volyansky A.Yu. The
degree and spectrum antimicrobial
activity 4-ed of derivative salts of
quinolinium is detennined. The activity
quinolinium of connections grampositive to bacteria and
Candida is more expressed. The
dependence "activity - structure" at
the majority derivative quinolinium of
new synthesis is determined.
Key words: 4-ed salt of quinolinium, microorganisms, antimicrobial activity. |
55-60 |
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| ÑÒÓϲÍÜ ÂÏËÈÂÓ ÏÐÎÑÒÎÐÎÂÎ ÐÎÇÃÀËÓÆÅÍÈÕ ÏÎÕ²ÄÍÈÕ ÔÅÍÎËÓ ÍÀ ÀÄÃÅÇÈÂͲ ² ÏÐÎÒÈ˲ÇÀÖÈÌͲ ÂËÀÑÒÈÂÎÑÒ² Ê˲Ͳ×ÍÎ ÇÍÀ×ÓÙÈÕ ÏÀÒÎÃÅͲ Ðóäåíêî Ë.Ì. DEGREE OF INFLUENCE OF REGIONALLY BRANCHED OUT DERIVATIVES OF PHENOLUM ON ADHESIVE AND ANTILYSOZYME PROPERTIES CLINICALLY MEANING PATHOGENS Rudenko L.M. In
researches in vitro presence at some regionally branched out Phenolums
in subbacteriostatic doses antiadhesive and antilysozyme properties is
certain. Keywords:derivatives of Phenolum, colonization, adhesion, a
lysozyme.
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61-66 |
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| ÂÏËÈ ÏÐÅÏÀÐÀÒÓ ÃÀËÀÂ²Ò ÍÀ ÖÈÒÎʲÍÎÂÈÉ ÄÈÑÁÀËÀÍÑ ÏÐÈ ÎÏÐÎ̲ÍÅÍͲ ÙÓв ˲Ͳ¯ WISTAR ÍÀ ÌÎÄÅ˲ ²ÍÔÅÊÖ²ÉÍÎÃÎ ÏÐÎÖÅÑÓ Áðóñí³ê Ñ.Â., Ìèõàéëè÷åíêî Ì.Ñ., ªãîøèíà Â. Î., Áîëõîâ³ò³íîâà À.²., Êîëÿäà Î.Í. INFLUENCE OF GALAVIT ON CYTOKINE DISBALANCE AT AN IRRADIATED WISTAR - RATS ON MODEL OF INFECTIOUS PROCESS Brusnik S.V., Mikhailichenko M.S., Egoshina V.O., Bolchovitinova A. I., Kolyada O.N. The
influence of low-dose γ-irradiation on
the antiinfectious resistance factors in animals was studied. The
present work displays some data concerning the influence of
immunomodulator agent Galavit on such
parameters, as cytokines levels (IL-4,
TNF-α and IFN-γ concentrations), in
antenatal or postnatal irradiation of
different intensity. It was shown that Galavit influence the
course of infectious process, caused by Salmonella typhimurium and
developing against a background of antenatal irradiation in the dose of
1 Gy positively. In particular,galavit stimulates the non-specific
defence factors and cytokines.
Key words: Galavit, immunomodulation, non-specific defence, γ-irradiation. |
66-68 |
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| ÑÒÓϲÍÜ ÂÏËÈÂÓ ÃÅÒÅÐÎÖÈÊ˲×ÍÈÕ ÏÎÕ²ÄÍÈÕ À̲ÍÎÖÓÊÐÎÕ²ÍÎË²Í²Þ ÍÀ Å˲̲ÍÀÖ²ÞÏËÀÇÌ²Ä ÀÍÒÈÁ²ÎÒÈÊÎÐÅÇÈÑÒÅÍÒÍÎÑÒ² ̲ÊÐÎÎÐÃÀͲÇ̲ Ðóäåíêî Ñ.Ñ. THE INFLUENCE OF HETEROCYCLIC AMINOSUGARCHINOLINE DERIVANTS ON ELIMINATION OF ANTIBIOTIC RESISTANCE PLASMIDS Rudenko S.S. The
influence of heterocyclic aminosugarchinoline and quaternary ammonium
derivants in subbacteriostatic doses (10-20 µg/ml) on elimination of R,
Hly., Ent in conjugation process was determined. The results canbe used
in clinical medicine for chemotherapy rationalization and
chemoprophylaxis.
Key words: aminosugarchinoline and quaternary ammonium derivants, anti-microbial agents resistance plasmids. |
69-79 |
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