Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| LISTERIOUS INVASION OF THE CENTRAL NERVOUS SYSTEM Krestetska S.L., Krestetsky N.G. Listeriosis
is life threatening food-related infection with systemic dissemination
of causative agent and multiple organs lesion. Although L.monocytogenes
is wide spread in the environment, listeriosis is uncommon illness in
the general population. The most vulnerable groups are neonates,
pregnant women, elders and patients with impaired cell-mediated
immunity. A failure of the immune system to control peripheral
infection substantially increases the risk for the cerebral
involvement. The latter ensures severe and often irreversible
consequences. In addition, the cases of listerious brain steam
encephalitis in previously healthy immunocompetent young adults have
been described. Unlike extracellular bacteria, that commonly invades
CNS with primary meningeal lesion, L.monocytogenes infection results in
a variety of CNS manifestations including meningitis,
meningoencefalitis, encephalitis and abscesses in the brain or spinal
cord. Diversity of clinical and pathological signs is determined by
multiple factors, but substantially reflects causative agent life style
features and different abilities to entry to the CNS that are ensured
by this features. The extensively raising published experimental data
array on this topic highlight some patterns of relationship which is
crucial for pathogenesis understanding
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5-9 |
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| ÑÎÂÐÅÌÅÍÍÛÅ ÏÎÄÕÎÄÛ Ê ÝÒÈÎÏÀÒÎÃÅÍÅÇÓ ÝØÅÐÈÕÈÎÇÎÂ Áàëóòà È.Ì., Âîðîíêèíà È.À. MODERN APPROACHES TO THE ETIOPATHOGENESIS ESHERIHIOSIS Balut IM, Voronkina IA At
present, acute intestinal infection (DCI) remains one of the pressing
problems of practical medicine. By Dann WHO in the world each year,
from 68.4 to 275 million cases of DCI, whose number is constantly
increasing. The incidence among children in 2,5-3 times higher than in
adults. Esherihiozy (colibacillosis) - the acute infectious diseases
with fecal-oral mechanism of transmission, primary lesion of the
gastrointestinal tract with the development of enteritis or
enterocolitis. It is currently known about 170 of antigenic variants of
E. coli; more than 80 of them cause colibacillosis. The disease is
widespread; epidemiological features esherihiozov caused by different
serovar may vary significantly.
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10-14 |
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| ÍÀÐÓØÅÍÈß Â ÑÈÑÒÅÌÅ ÈÌÌÓÍÎÁÈÎËÎÃÈ×ÅÑÊÎÃÎ ÍÀÄÇÎÐÀ ÏÐÈ ÁÎËÅÇÍßÕ ÈÌÌÓÍÍÎÉ ÀÓÒÎÀÃÐÅÑÑÈÈ Ó ÄÅÒÅÉ Êèñåëåâà Ë.Ï., Ñàââî Â.Ì., Ïàí÷åíêî Ë.À. CHANGES IN THE IMMUNOBIOLOGICAL CONTROL SYSTEM IN CHILDREN WITH IMMUNE ÀUTOAGGRESSION DISEASE Kyselyova L.P., Savvo V.M., Panchenko L.A. We have
studied in peripheral blood of 89 patients and synovial fluid of 24
patients diagnosed with rheumatoid arthritis (RA) the levels of CD3,
CD4, CD8 T- lymphocytes, CD19 B-lymphocytes, Ig A,M,G, circulating
immune complexes. We have also correlated the results with disease
activity index. We have found the higher levels of T cells and
circulating immune complexes in the synovial fluid. A negative
correlation was found between T cells and circulating immune complexes
in blood, T suppressors in blood and B-lymphocytes in the synovial
fluid. T cells is still thought to be a central event in the initiation
and progression of the disease.
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15-18 |
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| ÂÈÂ×ÅÍÍß
ÂÏËÈÂÓ ÅÊÑÏÅÐÈÌÅÍÒÀËÜÍÈÕ ÇÐÀÇʲ ÏÐÅÏÀÐÀҲ ÑÓÁÊ˲ÒÈÍÍÈÕ ÊÎÌÏËÅÊѲÂ
ÇÁÓÄÍÈÊÀ ÄÈÔÒÅв¯ ÍÀ ÀÊÒÈÂͲÑÒÜ ÔÀÃÎÖÈÒÎÇÓ ÏÐÈ ²ÌÓͲÇÀÖ²¯ ËÀÁÎÐÀÒÎÐÍÈÕ
ÒÂÀÐÈÍ ªëèñåºâà ².Â., Áàáè÷ ª.Ì., Æäàìàðîâà Ë.À., Êîëïàê Ñ.À., ²ãóìíîâà Í.²., Ñèäîðåíêî Ò.À., Áîáèðºâà ².Â. STUDY OF EFFECT OF EXPERIMENTAL SAMPLIES OF DIPHTHERIA PATHOGEN SUBCELLULAR COMPLEXES PREPARATIONS ON PHAGOCYTOSIES DURING LABORATORY ANIMALS IMMUNIZATIONS Yelyseyeva I.V., Babych Ye.M., Zhdamarova L.A., Kolpak S.A., Igumnova N.I., Sidorenko T.A., Bobireva I.V. Study is
dealt with evaluation of interrelationship between adjuvant effect of
examining antigenic preparations of subcellular complexes pathogenic
corynebacterium and phagocyte ability to consume diphtheria pathogen
cells. Month later after immunization by experimental samples of
antigenic preparations index of phagocytosis and phagocytic number have
increased meanwhile all values of monocyte phagocytic activity have
decreased
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19-22 |
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| ÏÅÐÑÈÑÒÅÍÖ²ß ÃÅÐÏÅѲÐÓѲ  ²ÌÓÍÎÖÈÒÀÕ ÕÂÎÐÈÕ ÍÀ ÃÎÑÒÐÈÉ ÊÎÐÎÍÀÐÍÈÉ ÑÈÍÄÐÎÌ Ïåðåìîò Ñ.Ä., Ñì³ëÿíñüêà Ì.Â., Âîëÿíñüêèé À.Þ., Êàøïóð Í.Â., Ðîìàíîâà Î.À., Ñèäîðåíêî Ò.À., ²ãóìíîâà Í.²., Ïåðåìîò ß.Î., Ìàðòèíîâ À.Â. HERPESVIRAL PERSISTENCE IN IMMUNOCYTES OF PATIENTS WITH ACUTE CORONAL SYNDROME Peremot S.D., Smelyanskaya M.V., Volyansky A.Y., Kashpur N.V., Romanova E.A., Sydorenko T.A., Igumnova N.I., Peremot Y.A., Martynov A.V. In work,
information is resulted on the exposure of antigens of viruses of
family of Herpesviridae in the leucocytes of patients with an acute
coronal syndrome. It is shown that the markers of six types of
herpesviruses are determined for all of patients. More frequent than
all there are associations of antigens of CMV, VEB, HHV6 and HSV-1.
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23-26 |
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| ÏÐÎÒÈÂÎÌÈÊÐÎÁÍÀß ÀÊÒÈÂÍÎÑÒÜ È ÄÅÇÈÍÔÈÖÈÐÓÞÙÈÅ ÑÂÎÉÑÒÂÀ ÍÎÂÎÃÎ ÀÍÒÈÑÅÏÒÈÊÀ ÄÅÇÀÊÒÈÍÀ Âîëêîâ À.À. ANTIMICROBIAL ACTIVITY AND DESINFECTIVE PROPERTIES OF A NEW ANTISEPTIC DESACTIN Volkov A.À. Antimicrobial
activity and desinfective action of a new antiseptic desactin have been
studied. It is recommended to use desactin in 0,5-1,0% concentration.
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27-36 |
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| ÀÍÒÈÒ²ËÎÃÅÍÅÇ
ÒÀ ÏÐÎÎÊÑÈÄÀÍÒÍÎ-ÀÍÒÈÎÊÑÈÄÀÍÒÍÈÉ ÁÀËÀÍÑ ÊÐβ ÙÓв ÇÀ ÓÌΠÙÅÏËÅÍÍß ÍÀ
Ò˲ ÊÎÌÏÅÍÑÀÖ²¯ òÏÎÒÈÐÅίÄÍÎÃÎ ÑÒÀÍÓ ÎÐÃÀͲÇÌÓ Êó÷ìà ².Þ., Íèêèò÷åíêî Þ.Â., Ñèìèðåíêî Ë.Ë., Âîëÿíñüêèé À.Þ. ANTIBODY GENESIS AND PROOXIDANT-ANTIOXIDANT BLOOD BALANCE OF RATS UNDER IMMUNIZATION AT THE BACKGROUND OF AN ORGANISM HYPOTHYROID CONDITION COMPENSATION Kuchma I.J., Nikitchenko J.V., Simirenko L.L., Voljanskij A.J. Specific
antibody genesis and prooxidant-antioxidant blood balance under
immunization by ADT-anatoxin and diphtherial anatoxin at the background
of compensation by Ò4 introduction of an organism hypothyroid
condition, induced by 1-metil-2-merkaptoimidazol, were studied at
3-month's rats males of Wistar line. Whey concentration of
antydiphterial and antytetanic antibodies at hypothyroid rats increased
to euthyroid animals level under T4 introduction in a dose 10 mkg per
100 g of body weight. It is established, that compensation of an
organism hypothyroid condition, caused by blocking of thyrocites
thyroid hormones secretion, causes. Blood whey glutathioneperoxidase
activity at rats with compensated of an organism hypothyroid condition
did not differ from activity at immunized euthyroid animals for 21-28
days after immunization, blood whey superoxidedismutase activity - for
7-28 days after immunization, and blood whey levels of both
enzyme-active ceruloplazmin and lipid hydroperoxides - throughout all
experiment (3-28 days).
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37-46 |
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| ÎÑÎÁÅÍÍÎÑÒÈ ÈÌÌÓÍÎËÎÃÈ×ÅÑÊÎÃÎ ÑÒÀÒÓÑÀ Ó ÏÀÖÈÅÍÒΠÎÑÒÅÎÀÐÒÐÎÇÎÌ Ñ ÌÅÒÀÁÎËÈ×ÅÑÊÈÌ ÑÈÍÄÐÎÌÎÌ Ãðèøèíà Å.È. CHARACTERISTICS OF THE IMMUNOLOGICAL STATUS IN PATIENTS WITH OSTEOARTHROSIS AND METABOLIC SYNDROME Grishyna O.I. The aim of
this study was to investigate the characteristics of the immune status
of patients with osteoarthrosis (OA) and the metabolic syndrome (MS)
compared to patients with MS-free OA. We examined 26 patients with OA
and MS and 19 - with MS-free OA. The patient with OA and MS have
activation of the inflammatory process that manifests itself in
increasing content of neutrophils and phagocytosis indices. System
immunologic response characterized by increased levels of lymphocyte
helper/inducer (CD3 +, CD4 +), cytotoxic lymphocytes (CD3 +, CD4 +), an
increase in the relative number of lymphocytes with CD16 +, CD20 + CD25
+ determinants and significantly higher content of the circulating
immune complexes.
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47-49 |
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| ²ñòîð³ÿ íàóêè (History of science) |
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| ÀÊÒÓÀËÜͲÑÒÜ
²ÄÅÉ ².².ÌÅ×ÍÈÊÎÂÀ ÍÀ ÑÓ×ÀÑÍÎÌÓ ÅÒÀϲ ÁÎÐÎÒÜÁÈ Ç ÒÓÁÅÐÊÓËÜÎÇÎÌ (ÄÎ
120-ÒÈ Ð²××ß ÉÎÃÎ ÏÓÁ˲×ÍÈÕ ËÅÊÖ²É Ç ÏÐÎÁËÅÌ ÒÓÁÅÐÊÓËÜÎÇÓ) Þð÷åíêî Â.Ä., Êîâãàí Ì.²., Øàïîâàë Â.Ô., Êó÷ìà ².Þ., Âîëÿíñüêèé À.Þ. MECHNIKOV'S IDEAS ACTUALITY IN THE MODERN STAGE OF FIGHT WITH THE TUBERCULOSIS (TO 120- YEARS OF HIS PUBLIC LECTURES ON THE PROBLEMS OF TUBERCULOSIS) YurchenkO V.D., Kovgan M.I., Shapoval V.F., Kuchma I.Yu., Volyanskiy A.Yu. In the
I.I.Mechnikov lectures cycle, which was read 120 years ago, scientific
-practical recommendations to prevention of the tuberculosis in people
and animal in a popular form were resulted. The ideas unspecific
prophylaxis of the infectious diseases, were marked at that time, are
very valuable and important for today.
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50-52 |
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