Ç̲ÑÒ (Contents)
|
|
C. (P.) |
|
|
Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
|
|
Çì³ñò (Contents) |
2-4 |
|
|
ÎÃËßÄÈ (REVIEWS) |
|
|
| ÍÅÔÅÐÌÅÍÒÈÐÓÞÙÈÅ ÃÐÀÌÍÅÃÀÒÈÂÍÛÅ ÁÀÊÒÅÐÈÈ Â ÝÒÈÎËÎÃÈÈ ÍÎÇÎÊÎÌÈÀËÜÍÛÕ ÈÍÔÅÊÖÈÉ È ÏÐÎÁËÅÌÛ ÀÍÒÈÁÈÎÒÈÊÎÐÅÇÈÑÒÅÍÒÍÎÑÒÈ ×åðíÿâñêèé Â.È., Áèðþêîâà Ñ.Â., Ãðèøèíà Å.È. NONFERMENTING GRAMNEGATIVE BACTERIA IN THE ETIOLOGY OF NOSOCOMIAL INFECTIONS AND PROBLEM OF DRUG- RESISTANCE Chernjavsky V.I., Birukova S.V., Grishina O.I. A review
is devoted to the group of nonfermenting bacteria (NFB) role of which
in etiology of nosocomial infections the last years increased
substantially. There is given the description of the most important
types of microorganisms of this group and factors, determining their
clinical value. The basic biochemical mechanisms of forming of drug-
resistance NFB are resulted to the widely utilized antibiotics, that is
the basic problem of therapy of diseases, conditioned these
microorganisms.
|
5-13 |
|
| Á²ÎËÎò×Ͳ ÂËÀÑÒÈÂÎÑÒ² ÁÀÊÒÅÐ²É ÐÎÄÓ STREPTOCOCCUS, ²ÇÎËÜÎÂÀÍÈÕ Â²Ä ÏÀÖ²ªÍҲ ²Ç ÀËÊÎÃÎËÜÍÈÌ ÄÅ˲вªÌ Ëóê’ÿíåíêî Ò. Â. BIOLOGICAL QUALITY OF STREPTOCOCCUS SP. ISOLATED FROM THE PATIENT WITH DELIRIUM ALCOHOLYCUM Lukyanenko T. V. Research
of biological quality Streptococcus sp. of pacients whith alcogolism is
problem of today. The patients whith alcogolism have the treatment of
antibiotics. The proportion of lethality among people who abuse alcohol
is about 4.21%. Diagnosis of streptococcosis require of conduction
bacteological investigations whith isolation and identification of
quality Streptococcus sp., serotaxonomy, definition of
antibiotic-sensitive. The assosiation whith pathogenic-germ heppine for
acquirement quality for persistencia Streptococcus sp., its afford to
persist in definite econishe. Streptococcosis cause of response whith
increase the antibody titer for extracellular antigen of Streptococcus
sp. streptolysine Î, deoxyribonuclease Â, hyaluronidase and al.
Also urgent development of a nutrient medium on the basis of vegetable
component whith selective qualities for Streptococcus sp. Desease of
streptococcosus depend on entry of infection, factors of pathogenety,
the ñîndition of immune system. Streptococcus sp. die under the
influence of pasteurization and of the process solution many
disinfectants, anticeptics, antibiotics. The bacterial count whith
antibiotic resistance increases. Problem of today use the quaternary
ammonium compound, the derivative of acridine and of quinolones.
|
14-25 |
|
| ÕÐÎÌÀÒÎÃÐÀÔ²×Ͳ ÌÅÒÎÄÈ: ÊËÀÑÈÔ²ÊÀÖ²ß, ÏÐÈÍÖÈÏÈ ÒÀ ÏÐÀÊÒÈ×ÍÅ ÇÀÑÒÎÑÓÂÀÍÍß Ðèæêîâà Ò.À., Áàáè÷ Å.Ì., Êàë³í³÷åíêî Ñ.Â., Ñêëÿð Í.²., Ðÿáîâîë Î.Â., Ïëóãàòîð Ò.Ì., Ãîðáà÷ Ò.Â., Àíòóøåâà Ò.²., Êàñüÿíåíêî Ò.Ì. CHROMATOGRAPHY: THE CLASSIFICATION OF CHROMATOGRAPHY, PRINCIPLES AND PRACTICE OF CHROMATOGRAPHY Ryzhkova T. A., Babych E.M., Kalinichenko S.V., Sklyar N.I., Rjabovol O.V., Plugator T.N., Gorbach T.V., Antusheva T.I., Kasjanenko T.N. The
history of chromatographic technique development is briefly described
in this article. The classifications of above mentioned methods by
stationary and mobile phases aggregate state, by mechanism of
separation, by form of stationary phase, by type of development process
are presented. The main principles of operation of chromatographic
apparatus, including chromatographic detectors, are characterized.
Chromatography nomenclature and formula evaluation of the main
chromatographic characteristics are presented. The different
chromatographic techniques applications are described.
|
26-34 |
|
| ÑÒÐÓÊÒÓÐÀ È ÁÈÎËÎÃÈ×ÅÑÊÀß ÀÊÒÈÂÍÎÑÒÜ ÍÅÊÎÒÎÐÛÕ ÐÀÑÒÈÒÅËÜÍÛÕ ÝËËÀÃÈÒÀÍÈÍÎÂ, ÂÛÄÅËÅÍÍÛÕ ÈÇ ÐÀÇÍÛÕ ÏÐÅÄÑÒÀÂÈÒÅËÅÉ ÐÎÄÀ ÌÈÐÒÎÂÛÕ Ìóñòàôà Àëü-Õóññåéí, Ìàðòûíîâ À.Â. STRUCTURE AND BIOLOGICAL ACTIVITY OF SOME VEGETABLE ELLAGITANNINS FROM MYRTACEAE Mustafa Al-Hussein, Martynov A. In the
article are presented the review about structure, activity, and
disseminating hydrolyzed tannins containing a fragment ellagic
(digallic) acids. It is shown that the widest possible group of tannins
in Myrtle. Virtually all of the family of this type contain some form
of ellagitannins. Presents the results of the study of biological
activity as individual substances from ellagitannins groups and summary
extracts: shows a powerful antioxidant, antidiabetics, anticancer,
antiviral, antifungal, antibacterial and antileishmania effects
specified connection. It is shown that the pharmacological activity
involves inhibition by ellagitannins the enzyme and manifests itself as
a model in vitro in animal models at very low toxicity. Presented the
conclusions about potential introduction of medicines based on
both new and newest group natural substances - ellagitannins.
|
35-42 |
|
| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
||
| ÀÍÒÈ̲ÊÐÎÁÍÀ ÀÊÒÈÂͲÑÒÜ ÅÊÑÒÐÀÊҲ IRIS PSEUDACORUS L. Çàòèëüí³êîâà Î.Î., Îñîëîä÷åíêî Ò.Ï., Êîâàëüîâ Â.Ì. ANTIMICROBIAL ACTIVITY OF EXTRACTS OF IRIS PSEUDACORUS L. Zatylnikova O.A., Osolodchenko T.P., Kovalev V.N. The
bactericidal activity of total preparations from the rhizomes and
leaves of Yellow Iris by agar diffusion and dilution technique was
established. The dry extracts of rhizome and leaves dissolved in water,
DMSO, 40% and 50% alcohol. A concentration presented 10,0% and 20,0%.
Preparations of rhizome (10,0%) have more expressed antibacterial
activity, than preparations are from leaves. The more sensible of
microorganisms appeared B.subtilis, S.aureus, P.aeruginosa, E.coli,
preparations showed a less sensitiveness to C.ablicans. The
antibacterial activity of preparations from the rhizome was confirmed
of method of dilution technique in relation to S.aureus (ÌRC of 5,0
mg/ml), Å. of coli (ÌRC of 5,0 mg/ml), P.àeruginosa (ÌRC of 10,0
mg/ml). For preparations of leaves ÌRC arrives at 20,0 mg/ml.
Preparations answer the requirements of Pharmacopoeia of Ukraine at
research on a microbiological cleanness.
|
43-47 |
|
| ÏÎÊÀÇÍÈÊÈ ÐÅÇÈÑÒÅÍÒÍÎÑÒ² Ó ÕÂÎÐÈÕ ÍÀ ÏÍÅÂÌÎÍ²Þ Ð²ÇÍί ÅÒ²ÎËÎò¯ ªãîøèíà Â.Î., Êîëÿäà Î.Ì., Áðóñí³ê Ñ.Â., Ìèõàéëè÷åíêî Ì.Ñ., Àòò³êîâ Â.ª., Íåñòåðåíêî À.Ì., Êîëÿäà Ò.². IMMUNOLOGIC FEATURES OF THE CURRENT OF THE PNEUMONIA OF DIFFERENT ETIOLOGY Egoshina V.A., Koljada O. N., Brusnik S.V., Mihajlichenko M. S., Nesterenko A.M., Attikov V. E., Koljada T.I. Spent
immunologic inspection patient with nonhospital pneumonia of a various
etiology. During research it has been established, that atypical unlike
a staphylococcus pneumonia develop against oppression of the T-cellular
link, and in a smaller measure of phagocytic reaction. There are also
changes in a humoral link of immunity, about what quantity rising
Blymphocytes (CD19 +), IgM titer and CIC level testifies. At
staphylococcus pneumonia prevalence of the proinflammatory cytokines
takes place. Absence of rising of level of proinflammatory cytokines,
especially ²L-1β, at pneumonia advance is prognostically adverse.
|
48-52 |
|
| Ä²ß ÀÍÒÈÑÅÏÒÈ×ÍÈÕ ÇÀÑÎÁ²Â ÍÀ ÏÀÒÎÃÅÍͲ ÌÅÕÀͲÇÌÈ ÁÀÊÒÅÐ²É Æîðíÿê Î. ²., Ñòóêàí Î. Ê., Ñóõëÿê Â. Â. ACTION OF THE PILL ANTISEPTICS ONTO PATHOGENIC MECHANISMS OF BACTERIA Zhornjak O. I., Stukan O. K., Suchljak V. V. The
results of studying of effect of antimicrobial agents on the adhesion
of gram-positive and gram-negative microorganisms were discribed.
Studies have shown that antiseptics septefril, sebidin, adzhysept
inhibited adhesion of bacteria. The lowest index of adhesiveness
observed in the presence of septefril was - 39,51-34,08% for
museum strains of staphylococcus and 51,7-51,9% for clinical strains of
staphylococcus, that in 2,53 and 1,93 times less in comparison with the
control.
|
53-58 |
|
| ÂËÈßÍÈÅ
ÒÅÐÀÏÈÈ ÈÌÌÓÍÎËÎÃËÎÁÓËÈÍÎÌ ×ÅËÎÂÅÊÀ ÍÎÐÌÀËÜÍÛÌ ÄËß ÂÍÓÒÐÈÂÅÍÍÎÃÎ
ÂÂÅÄÅÍÈß ÍÀ ÎÑÍÎÂÍÛÅ ÏÀÐÀÌÅÒÐÛ ÌÅÑÒÍÎÃÎ È ÑÈÑÒÅÌÍÎÃÎ ÈÌÌÓÍÈÒÅÒÀ ÄÅÒÅÉ,
×ÀÑÒÎ ÁÎËÅÞÙÈÕ ÎÑÒÐÛÌÈ ÐÅÑÏÈÐÀÒÎÐÍÛÌÈ ÈÍÔÅÊÖÈßÌÈ Ñ ÑÈÍÄÐÎÌÎÌ
ËÈÌÔÀÄÅÍÎÏÀÒÈÈ Ïîïîâ Í.Í., Ñàââî À.Í., Êîëèóøêî Å.Ã. INFLUENCE OF THERAPY BY AN IMMUNOGLOBULIN OF THE PERSON NORMAL FOR INTRAVENOUS INTRODUCTION ON KEY PARAMETERS LOCAL AND SYSTEM IMMUNITY CHILDREN, OFTEN ILL SHARP RESPIRATORY VIRUS INFECTIONS WITH A SYNDROME LYMPHADENOPATHY Popov N.N., Savvo A.N., Koliushko E.G. The
purpose of the present research was studying of efficiency of
application of an intravenous immunoglobulin (IVIG) in treatment of
often ill children by sharp respiratory virus infections with a
syndrome lymphadenopathy. The obtained data specifies that application
ivig allows about treatment terms, in 3 times reduces disease DRS
within a year, warns development of bacterial complications, liquidates
lymphadenopathy. At children receiving IVIG, dynamical increase of
local and system immunity, activization of anti-virus immunity,
normalization of funktsional th activity of lymphocytes and phagocytes
cages is observed. Under the influence of IVIG spontaneous and
IL-2-induction proliferative activity of lymphocytes, and also
spontaneous production IL-2 and IL-10 at patients decrease to normal
values. The offered therapy allows to normalize in short terms
it-munnye processes with which development of lymphadenopathy
associates.
|
59-65 |
|
| ÄÎÑ˲ÄÆÅÍÍß ÏÐÎÒÈÃÐÈÁÊÎÂί ÀÊÒÈÂÍÎÑÒ² ÊÎÌÁ²ÍÎÂÀÍÈÕ ÏÅÑÀв¯Â «Ê˲ÌÅÄÅÊÑ» Ëåâà÷êîâà Þ.Â. Ñòåïàíîâà Ê.Î. SCIENTIFIC INVESTIGATION OF ANTIMYCOTIC ACTION OF COMBINED PESSARIES “CLIMEDEX” Levachkova Y.V., Stepanova K.A. Data
of microbiological studies of combined pessaries on the base of
substances of synthetic and natural origin have been given and the
perspectiveness of development of combined remedy for treating of
vaginal candidosis is shown. By the conducted analysis of
antimycotic activity of pre-productions models of pessaries with
fluconazole depending on his maintenance, it was set, that all
standards have a moderate or expressed antimycotic effect as compared
to the control, however most rational and perspective for the further
study there is a standard 2b of combined pessaries «Climedex». In
addition, it is defined from data of experiment, that adding of
fluconazole to the composition of a drug allows to extends its
pharmacological spectrum of action.
|
66-68 |
|
| ²ÌÓÍÎËÎò×Ͳ
ÊÐÈÒÅв¯ ÏÐÎÃÍÎÇÓÂÀÍÍß ÐÈÇÈÊÓ ÐÎÇÂÈÒÊÓ ÃÎÑÒÐÎÃÎ ÊÎÐÎÍÀÐÍÎÃÎ ÑÈÍÄÐÎÌÓ Ó
ÎѲÁ Ç ²ØÅ̲×ÍÎÞ ÕÂÎÐÎÁÎÞ ÑÅÐÖß, ²ÍÔ²ÊÎÂÀÍÈÕ Â²ÐÓÑÀÌÈ ÐÎÄÈÍÈ
HERPESVIRIDAE Ïåðåìîò Ñ.Ä., Ñì³ëÿíñüêà Ì.Â., Âîëÿíñüêèé À.Þ., Ïåðåìîò ß.Î., Êàøïóð Í.Â., Óñåíêî Ñ.À. IMMUNOLOGICAL CRITERIA OF PROGNOSTICATION OF RISK OF DEVELOPMENT OF ACUTE CORONAL SYNDROME AT PERSONS WITH ISCHEMIC HEART DISEASES, INFECTED THE VIRUSES OF HERPESVIRIDAE Peremot S.D., Smelyanskaya M.V., Volyanskiy A.J., Peremot J.A., Kashpur N.V. Immunological
criteria of prognostication of risk of development of acute coronal
syndrome (ACS) at persons with IHD infected the viruses of family of
Herpesviridae. The increases of risk of origin of ACS establish at
presence of tendency to the decline (on 33 % and more) of amount
of lymphocytes of CD3, CD4, CD8 and their correlation (CD4/CD8),
decline of indexes of reaction functionly incomplete T lymphocytes at
the simultaneous increase (on 33 % and more) of indexes of maintenance
of proinflammatory TNF, and also to the exposure of antigens of viruses
of family of Herpesviridae in leucocytes (IF).
|
69-72 |
|
| ßÌÐ-ÄÈÀÃÍÎÑÒÈÊÀ ÍÀÍÎÊÎÌÏÎÇÈÒΠÍÀ ÎÑÍÎÂÅ ÃÈÄÐÎÃÅËÅÂÛÕ ÌÀÒÐÈÖ, ÑÎÄÅÐÆÀÙÈÕ ÈÍÊÎÐÏÎÐÈÐÎÂÀÍÍÛÉ ÃÈÄÐÎÊÑÈËÀÏÀÒÈÒ Áîëäåñêóë È.Å, Ñàì÷åíêî Þ.Ì., Äàíèëü÷åíêî Ñ.Í., Òðà÷åâñêèé Â.Â., Ñóõîäóá Ë.Á., Âîëÿíñêèé À.Þ., Êó÷ìà È.Þ., Óëüáåðã Ç.Ð., Ñóõîäóá Ë.Ô. 31Ð ÌÀS MRS DIAGNOSTIC OF THE HYDROGEL-BASED NANOCOMPOSITES WITH INCORPORATED HYDROXYAPATITE Boldeskul I.E. Samchenko Y.M., Danilchenko S.N., Trachevsky V.V., Sukhodub L.B. , Voljansky A.Y., Kuchma I.Y., Ulberg Z.R., Sukhodub L.F. 31Ð ÌÀS
Magnetic resonance spectra have demonstrated that the hydration level
of the hydrogel matrix before treatment by ammonia solution (at the end
stage) crucially influence of the structure of calcium phosphates. The
predominant formation of the hydroxyapatite takes place when the
structure has a maximum hydration level. In the dehydration case of the
same structure a TCP phase is formed.
|
73-78 |
|
| ÂÈÂ×ÅÍÍß
ÄÅßÊÈÕ ÔÀÊÒÎв ÏÅÐÑÈÑÒÅÍÖ²¯ ÀÍÒÈÁ²ÎÒÈÊÎÐÅÇÈÑÒÅÍÒÍÈÕ ÇÁÓÄÍÈʲ ÃͲÉÍÎ-
ÇÀÏÀËÜÍÈÕ ÓÑÊËÀÄÍÅÍÜ Â ÒÎÐÀÊÎÀÁÄÎ̲ÍÀËÜÍ²É Õ²ÐÓÐò¯ Äÿ÷åíêî Â.Ô., ßãíþê Þ.À., Ìàðþùåíêî À.Ì., Áàêóìåíêî À.Â., Ãîðîäíèöüêà Í.². STUDY OF SOME PERSISTANCE FACTORS OF ANTIBIOTIC- RESISTANCE STRAINS OF PYOINFLAMMATORY COMPLICATIONS IN THORACOABDOMINAL SURGERY Dyachenko V.F, Yahnyuk J.A, Maryuschenko A.M, Bakumenko A.V., Gorodnitskaya N.I. The
research of persistance properties (antilyzocimic, anticomplementic and
adhesive activity)of strains of pyo-septic infections which was
selected in thoracoabdominal surgical hospitals was conducted and was
assessed their informative in predicting of the formation of
antibiotic-resistants these pathogens. Established that antibiotic-
resistants strains created more significant depressing effect
against complement and lysozyme than the moderately resistant.
|
79-81 |
|
| ÄÈÔÔÅÐÅÍÖÈÀËÜÍÎ-ÄÈÀÃÍÎÑÒÈ×ÅÑÊÀß
ÑÎÏÎÑÒÀÂÈÌÎÑÒÜ ÌÎÐÔÎËÎÃÈ×ÅÑÊÈÕ ÌÀÐÊÅÐΠÎÑÏÀËÈÒÅËÜÍÎ-
ÄÅÃÅÍÅÐÀÒÈÂÍÛÕ ÈÇÌÅÍÅÍÈÉ Â ÃÎËÎÂÍÎÌ ÌÎÇÃÅ ÏÐÈ ÈØÅÌÈ×ÅÑÊÎÌ ÈÍÑÓËÜÒÅ È
ÃÅÐÏÅÑÂÈÐÓÑÍÎÉ ÍÅÉÐÎÈÍÔÅÊÖÈÈ (ÏÎ ÄÀÍÍÛÌ ÊËÈÍÈÊÎ- ÝÊÑÏÅÐÈÌÅÍÒÀËÜÍÛÕ ÈÑÑËÅÄÎÂÀÍÈÉ) Òîðÿíèê È.È., Êîëåñíèê Â.Â. DIFFERENTIAL AND DIAGNOSTIC COMPARIENCE OF THE MORPHOLOGICAL MARKERS OF THE INFLAMMATORY AND DEGENERATIVE CEREBRAL CHANGES IN THE ISCHEMIC STROKE AND HERPESVIRAL NEUROINFECTION (for the data of the clinical and experimental investigations) Torianik Inna I., Kolesnik Vladimir V. The
studing results of the differential and diagnostic comparience of the
morphological markers of the inflammatory and degenerative cerebral
changes in the ischemic stroke and herpes virus neuroinfection were
presented in the article. The research material were the data of the
clinical and the experimental elaborations. With the morphological
methods analysis was revealed: hyperchromatism of the neurocyte’s,
fragmentation of the chromatin, karyopyknosis, destruction of the
mitochondrion, the granular and a granular reticulum, availability of
the lysosomic inclusion, vacuolar dystrophy. Symptoms of the focal
gliosis and the cells- shadow accumulation around the pathologically
changed capillary was taked is a special place in the differential
diagnostic of each pathology. Microvessels and neurocytes structure
changes were been accompanied astrocyte processes oedema. Infiltrative
and proliferative symptoms were demon- strated inflammatory reaction.
|
82-85 |
|
| ÂÏËÈ ÌÓËÜÒÈÏÐÎÁ²ÎÒÈÊÓ «ÑÈÌÁ²ÒÅÐ-2» ÍÀ ̲ÊÐÎÁ²ÎÇÅÍÎÇ ÐÎÒÎÂί ÏÎÐÎÆÍÈÍÈ Ó ÕÂÎÐÈÕ ÍÀ ÂÒÎÐÈÍÍÓ ÀÄÅÍÒ²Þ Áàëàê Î.Ê. THE INFLUENCE OF MULTIPROBIOTIC “SIMBITER-2” ON THE MOUTH’S MICROBIOCENOSIS OF THE PATIENTS WITH SECONDARY ADENTIA Balak O. K. The
article is devoted to increasing the effectiveness of therapy of
patients with secondary adentia and to improving of microbiocenotic
rehabilitation of patients with secondary adentia that are in need of
orthopedic treatment with taking off dentures accounting
microbiological monitoring and immunological, biological indexes. The
peculiarities of mouth’s microbiocenosis in the treatment using the
probiotic “A-bacterin” and symbiotic “Simbiter-2” in combination are
determined.
|
86-90 |
|
Þâ³ëå¿ |
||
| 80-ËÅÒÍÈÉ ÞÁÈËÅÉ ÌÀÊÀÐÅÍÊÎ ÊÎÍÑÒÀÍÒÈÍÀ ÊÎÍÑÒÀÍÒÈÍÎÂÈ×À (ïàìÿòè Ó÷èòåëÿ, ó÷åíîãî, ïåäàãîãà, âðà÷à) |
91 |
|
