Ç̲ÑÒ (Contents)
|
|
C. (P.) |
|
|
Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
|
|
Çì³ñò (Contents) |
2-4 |
|
|
ÎÃËßÄÈ (REVIEWS) |
|
|
| ÀÄÚÞÂÀÍÒÛ Â ÑÎÂÐÅÌÅÍÍÎÉ ÂÀÊÖÈÍÎËÎÃÈÈ Èñàåíêî Å.Þ., Áàáè÷ Å.Ì., Åëèñååâà È.Â., Æäàìàðîâà Ë.À., Áåëîçåðñêèé Â.È., Êîëïàê Ñ.À. ADJUVANTS IN MODERN VACCINOLOGY Isaenko Ye. Yu., Babych Ye. M., Yelyseyeva I. V., Zhdamarova L. A., Belozersky V. I., Kolpak S. A. A concept
of adjuvants and their story of creation is characterized in the
article. They’re presented the various types of non-specific
stimulators of immune systeme, thier excipients and classification.
They’re described basic properties of adjuvant systems, their
significant advantages and disadvantages. Particular attention is paid
to the numerous antigen delivery systems, including alive vectors,
nanoparticles, bacterial toxins, etc. They’re considered non-specific
stimulators mechanisms of action on immune system and their interaction
with antigens. They’re given examples of different adjuvants in
licensed vaccines use.
Key words: adjuvants, non-specific stimulators of immune systeme, antigen delivery systems antigen delivery systems, immunogenicity, immunity. |
5-21 |
|
| ÐÎËÜ ÅÍÒÅÐÎÊÎÊ²Â Ó ÂÈÍÈÊÍÅÍͲ ÍÎÇÎÊÎ̲ÀËÜÍÈÕ ²ÍÔÅÊÖ²É (îãëÿä ë³òåðàòóðè) Ïåðåòÿòêî Î.Ã. ROLE OF ENTEROCOCCI IN THE OCCURRENCE OF NOSOCOMIAL INFECTIONS (REVIEW) Peretyatko E. G. In the
article considers the role of microorganisms of the
genus Enterococcus in the occurrence of
nosocomial infections. The most common nosological forms of
infections enterococci’s etiology: urinary tract infections, infectious
endocardit, sepsis, gynecological, neonatal, intraabdominal infections
and infectious-inflammatory soft tissue lesions. Shows the
clinical role not only E. faecalisand E. faecium, but other
species, namely: E. avium, E. casseliflavus, E. durans, E. gallinarum,
E. hirae, E. malodoratus, E. mundtii, E. raffinossus, E. solitarius.
Key words: enterococci, nosocomial infection, etiological role, E. faecalis, E. faecium. |
22-27 |
|
| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
||
| VALUE OF HOUSE AEROALLERGENS IN THE ETIOLOGICAL SPECTRUM OF BRONCHIAL ASTHMA IN CHILDREN Makeeva N.I., Shmulych V.K., Chernenko L.N., Staruseva V.V., Shmulych A.V., Parameyeva K.O. 1487
children with asthma were examined
by prick- test method. Were made a
comparative assessment of the etiological
significance of house aeroallergens: house dust mites, bird’s feathers,
chironomids, fungas in the formation of bronchial asthma in
children. Defined a dominating allergen from the house dust (Allergenum e pulvere domesticum e Dermatophagoides pteronyssinus), which could be used to optimize the specific immunotherapy of asthma in children. Keywords: asthma, house aeroallergens, etiologic significance, children. |
28-32 |
|
| Ä²ß ÓËÜÒÐÀÇÂÓÊÎÂÎÃÎ ÂÈÏÐÎ̲ÍÞÂÀÍÍß ÍÀ ÑÔÎÐÌÎÂÀͲ Á²ÎÏ˲ÂÊÈ ÒÀ ÇÄÀÒͲÑÒÜ ÄÎ ¯Õ ÔÎÐÌÓÂÀÍÍß S.AUREUS ̳øèíà Ì.Ì. EFFECT OF ULTRASOUND RADIATION ON FORMED BIOFILMSAND ABILITY TO THEIR FORMATION IN S.AUREUS Mishina M.M. Microbiological
research of the clinical material received from with inflammatory
processeswas carried on that to detect ability to form biofilmsand to
study effect of low-intensity ultrasound radiation on formed
biofilmsand their aggregation ability. Performed research showed that
ultrasound radiation of low intensity could destroy biofilmsand inhibit
ability of microorganisms to form secondary biofilms.
Key words: ultrasound radiation, biofilms, S.aureus.
|
33-36 |
|
| ÂÈÂ×ÅÍÍß
ÂÏËÈÂÓ ÓËÜÒÐÀÇÂÓÊÎÂÎÃÎ ÂÈÏÐÎ̲ÍÞÂÀÍÍß ÍÀ ÇÄÀÒͲÑÒÜ ÄÎ ÔÎÐÌÓÂÀÍÍß
Á²ÎÏ˲ÂÎÊ ÒÀ ÍÀ ÑÔÎÐÌÎÂÀͲ Á²ÎÏ˲ÂÊÈ KLEBSIELLA PNEUMONIAE Ìîçãîâà Þ.À. STUDY OF ULTRASOUND RADIATION INFLUENCE ON ABILITY TO FORM BIOFILMS AND FORMED BIOFILMS OF KLEBSIELLA PNEUMONIAE Mozgova Yu.A. With aim
to detect ability to form biofilms in K. pneumoniaeand to study effects
of low-intensity ultrasound radiation on formed biofilms and their
aggregation microbiological research of material from patients with
pyoinflammatory diseases was performed. It was found that low-intensity
ultrasound radiation could destroy formed biofilms of K.
pneumoniae and decrease ability of this pathogen to form secondary
biofilms.
Key words: biofilm, Klebsiella pneumoniae,low-intensity ultrasound radiation. |
|
|
| ̲ÊÐÎÁÍÀ ÔËÎÐÀ ÐÎÒÎÃËÎÒÊÈ ÏÐÈ ÇÀÕÂÎÐÞÂÀÍÍßÕ ÍÀ ÃÐÈÏ ÒÀ Ãв Êëèìíþê Ñ.²., Ïîêðèøêî Î.Â, Ñàâ÷óê Ì.Ì., Ðîìàíþê Ë. Á., Òêà÷óê Í. ²., Àíäðåé÷èí Þ. Ì. MICROBIAL FLORA OF STOMASTOPHARYNX IN PEOPLE WITH INFLUENZA AND ACUTE RESPIRATORY VIRAL INFECTIONS Klymnyuk S. I., Pokryshko O. V., Savchuk M.M., Romanyuk L.B., Òkachuk N.²., Andreichyn Y.M. Stomatopharynx
samples of 146 patients with influenza and acuterespiratoryviral
infections were investigated. Diagnosis of influenza was confirmedin
2,7 % patients, the remaining persons had acuterespiratoryviral
infections and their complications. Oropharyngeal microbiocenosis was
represented by associations of facultative anaerobic,aerobic, ahaerobic
bacteria, and fungi. Almost allisolated strains (97,2 %) had bacterial
nature, rest ones belonged to Candidagenus.Bacteria were represented by
3 types and 7 classes. Coccal bacteria – Streptococci and
Staphylococcicolonized stomatopharynx mucosa most frequently – 91,8 %
and 74,7 % of patients accordingly. Corynebacteria spp, Moraxellaspp.
and Neisseriawere presented in patients microbiocenosis in 3,3-4,1
times less. Haemophilusspp. colonized mucosa of 7,5 % of patients.
Other bacteria had low consistency indexes that’s why there are typical
transient inhibitants of mucosa. In Staphylococcus community there were
two genera of cocci: Staphylococcus (98,2 %of strains) and
Gemella –1,8 %.Coagulase positive staphylococci S. aureusand S.
intermedius put together 30,6 % of proper community. Another cocci
belonged to coagulase negative ones.Colonizational level of coagulase
positive cocci was in ten- hundred times more than coagulase negative
ones - about 5,9-6,4 lg CFU/ml. Micrococcus community was present
by Micrococcus, Dermacoccus, Kokuria, and Rothia genera.
Their colonization level fluctuated between 4,1 (Micrococcus) – 6, 4
(Rothia) lg CFU/ìl. Moraxella spp. were dominated in community of
Moraxellaand Neisseria.(64, 1 %of strains) Such rare inhabitants
of stomatopharynx microbiocenosis as Rothiaspp., Granilicatellaspp.,
Gemellaspp., Facklamiaspp., Lactococcusspp., are appeared in patients
with flue and acute respiratory viral infections. This situation may be
as a result of dysbiosis formation in this biotope.
Key words: ifluenza, acute respiratory viral infections, stomatopharynx, microbiocenosis. |
41-48 |
|
| ÄÎÑ˲ÄÆÅÍÍß ÂÏËÈÂÓ ÊÎÌÁ²ÍÀÖ²É ÀÍÒÈÁ²ÎÒÈʲ ÍÀ ÌÓÇÅÉͲ ÏÎ˲ÀÍÒÈÁ²ÎÒÈÊÎÐÅÇÈÑÒÅÍÒͲ ØÒÀÌÈ ÑÈÍÜÎÃͲÉÍί ÏÀËÈ×ÊÈ Äÿ÷åíêî Â.Ô., ßãíþê Þ.À., Ìàðþùåíêî À.Ì., Áîìêî Ò.Â., Áàêóìåíêî À.Â., Ãîðîäíèöüêà Í.². THE STUDY OF ANTIMICROBIAL ACTION OF COMBINATION OF ANTIBIOTICS AGAINST POLYANTIBIOTICRESISTANT STRAINS OF PSEUDOMONAS AERUGINOSA BY OF CHECKERBOARD METHOD Dyachenko V.F. , Yagniuk Yu.A., Mariushchenko A.M., Bomko T.V., Bacumenko A.V., Gorodnitskaya N.I. Many
researchers fromdifferent countries are searching synergistic
combinations of antimicrobial preparations that allow, first of all, to
achieve the elimination of severe infections caused by multiresistant
pathogens. Research conducted under the direction of Sh. Oie and M.
Masako, T. Kazumi et al. demonstrated the effectiveness of two- and
three-component combinations of antibiotics for multidragresistant
strains of P.aeruginosa. The result of experimental study
by of method “time-bactericidal effect”was shown the high effectiveness
of the combinations of cefepime and ciprofloxacin in relation to four
museums multiresistant Pseudomonas aeruginosa strains obtained from the
Museum of microorganisms of State Establishment “Mechnikov Institute of
Microbiology and Immunology of the National Academy of Medical Sciences
of Ukraine”.
Key woards: combinations of the antibiotics,polyantibiotic-resistant strains, method“time-bactericidal effect”. |
49-52 |
|
| ÎÁÃÐÓÍÒÓÂÀÍÍß ÂÈÁÎÐÓ ÀÍÒÈÑÅÏÒÈÊÀ ÄËß ÊÎÌÏËÅÊÑÍÎÃÎ ÍÀÇÀËÜÍÎÃÎ ÏÐÅÏÀÐÀÒÓ Ç ÀÍÒÈ̲ÊÐÎÁÍÎÞ ÒÀ ÑÓÄÈÍÎÇÂÓÆÓÂÀËÜÍÎÞ Ä²ªÞ Áîéêî Ì.Ì., Íåôüîäîâà Ë.Â., Ðèáàëê³í Ì. Â., Îñîëîä÷åíêî Ò.Ï. ANTISEPTIC SELECTION RATIONALE FOR COMPLEX NASAL MEDICINE HAVING ANTIMICROBIAL AND VASOCONSTRICTOR ACTION Boyko, N.N., Nefedovà, L.V., Rybalkin, N.V., Osolodchenko, T.P. Screening
of antimicrobial properties of Myramistinum 0.01 % solution, Decasanum
0.02 % solution, Chlorhexidine digluconate 0.05 % solution,
Benzalkonium chloride 0.05 % solution, and Octenisept 0.1 % solution
has been carried out. It has been found that Chlorhexidine digluconate
0.05 % solution has the greatest antimicrobial activity, whereas
Myramistinum 0.01 % solution has the lowest activity. For manifestation
of optimal antiseptic properties of cation-active antiseptics, it is
proposed to increase their concentration in the preparation by not less
than 0.05% and not more than 0.1%. It is noted that use of Octenisept
is inefficient due to its expensiveness and high concentration needed
to achieve the optimal level of manifestation of its anti-microbial
properties.
Keywords: nasal medicine, antiseptics, screening microbiological studies. |
53-56 |
|
| ÑÎÑÒÎßÍÈÅ ÍÅÑÏÅÖÈÔÈ×ÅÑÊÎÉ ÐÅÇÈÑÒÅÍÒÍÎÑÒÈ ÎÐÃÀÍÈÇÌÀ ÐÀÁÎ×ÈÕ, ÇÀÍßÒÛÕ ËÈÒÜÅÌ Â ÏÎÑÒÎßÍÍÛÅ ÌÅÒÀËËÈ×ÅÑÊÈÅ ÔÎÐÌÛ Çàâãîðîäíèé È.Â., Ïåðöåâ Ä.Ï., Íèêóëèíà Í.À., Íèêóëèíà Ã.Ë. STATE NONSPECIFIC RESISTANCE OF WORKERS EMPLOYED BY INJECTION IN A CONSTANTLYMETAL FORMS Zavgorodniy I.V., Peppers D.P., Nikulin N.A., Nikulin G.L. The purpose of
this paper is to examine the state of nonspecific resistance in 52 men
aged 22 to 57 years working in the foundry industry for at least three
years ( professional groups - studied - zalivschiki, naplavschiki and
smelters, the control group - fitters, turners) to Kharkov by copyright
invention number 1180000. To determine the status of non-specific
resistance of peripheral blood was used. In the blood was determined by
the total number of white blood cells, the percentage of cells in the
human leucocyte leykoformule, phagocytic reaction rates as indicators
of non-specific cell-mediated resistance. The serum titer of
agglutinins and lysozyme activity as indicators of humoral non-specific
resistance. On the basis of these data, calculated the integral index
of nonspecific resistance. Calculated on the basis of the obtained data
the figures are non-specific resistance of the first group within Abs.n
91,68 ± 3,33, in the second - 104,94 ± 4,18 abs.n, a third - 102,87 ± 1
98 abs.n, in the fourth - 105,077 ± 4,86 abs.n at the rate of 110-140
abs.n Revealing the quantitative reduction of the level of non-specific
resistance index shows a decline in the overall resistance of the
organism associated with the working conditions in this industry.
Keywords: non-specific resistance, prenosological diagnostics, foundry industry |
57-60 |
|
| ÑÒÓϲÍÜ ÂÏËÈÂÓ ÒÅÒÐÀÖÈÊ˲ÍÓ ÍÀ ̲ÊÐÎÁ²ÎÖÅÍÎÇ ÊÈØÅ×ÍÈÊÓ ÒÀ ÉÎÃÎ ÊÎÐÅÊÖ²ß ÏÐÅÏÀÐÀÒÎÌ «Á²Ô²ÔÎÐÌ – 21» Ãîëÿð Î.²., Ñèäîð÷óê ².É. THE DEGREE OF TETRACYCLINE EFFECTS ON THE INTESTINAL MICROBIOCENOSIS AND ITS CORRECTIONS BY «BIFIFORM – 21» Holyar O.I., Sydorchuk I.Y. The paper
presents a theoretical synthesis and scientific solution of scientific
problem, grounded on the experimental side effects of broad-spectrum
antibiotic (tetracycline hydrochloride) on qualitative and quantitative
composition of the microbiota in the biological layer on mucus membrane
of colon and distal part of small intestine; substantiation of
self-healing process within 10 days qualitative and quantitative
composition of the microbiota of given biotype, depending on the dose
of tetracycline (average and maximum therapeutic dose) orally
administered white rats, and the influence of probiotic «Child
powder Bifiform number 21» on the restoration of the qualitative
and quantitative composition of the gut microbiome.
Keywords: microbiome, large and small intestine, normal flora, dysbacteriosis, tetracycline. |
61-70 |
|
| ÌÀÊÐÎ̲ÊÐÎÑÊÎϲ×ÍÀ ÒÀ ÓËÜÒÐÀ̲ÊÐÎÑÊÎϲ×ÍÀ ÕÀÐÀÊÒÅÐÈÑÒÈÊÀ ÑÅÐÖß ÒÀ ÉÎÃÎ ÑÓÄÈÍ ÏÐÈ ÅÊÑÏÅÐÈÌÅÍÒÀËÜÍ²É ÅÐ˲ղÎÇÍ²É ²ÍÔÅÊÖ²¯ Ó ÌÈØÅÉ Ïîõèë Ñ.²., Òîðÿíèê ².²., Òèì÷åíêî Î.Ì., ×èãèðèíñüêà Í.À., Êîñòèðÿ ².À., Êèëèïêî Ë.Â. MACROMICROSCOPIC AND ULTRAMICROSCOPIC CHARACTERISTICS OF THEHART AND ITS BLOOD VESSELS IN MICE EHRLICHIOSIS INFECTION Sergey I. Pokhil, Inna I. Torianik, Olena M. Timchenko, Nila A. Chigirinsky, Irina A. Kostyria, Ludmila V. Kylypko The
macromicroscopic, ultramicroscopic studying change’s in the hart and
its blood vessels in unlinear immunocomprometive laboratory male and
female mice with the experimental ehrlichiosis is presented in this
article. The cardiac destructive and degenerative changes,
cardiomyopathy, cardiosclerosis had been established in experimental
animal group’s. The blood vessels endothelial lieyr disorganization,
stasis, thrombosis has been noted.
Key words:macromicroscopic, ultramicroscopic changes, the unlinear immunocomprometive laboratory male and female mice, ehrlichiosis, cardiac muscles and blood vessels, cardiomyopathy, stasis, trombosis. |
71-74 |
|
| ÎÑÎÁËÈÂÎÑÒ²
Ê˲ÒÈÍÍÎÃÎ ²ÌÓͲÒÅÒÓ Ä²ÒÅÉ, ÕÂÎÐÈÕ ÍÀ ÕÐÎͲ×ÍÓ ÃÅÐÏÅѲÐÓÑÍÓ ²ÍÔÅÊÖ²Þ,
ÇÀËÅÆÍÎ Â²Ä Â²ÊÓ ÒÀ ÑÒÓÏÅÍÞ ²ÍÔ²ÊÎÂÀÍÎÑÒ² ²ÐÓÑÀÌÈ Ð²ÇÍÈÕ ÒÈϲ Âîëÿíñüêèé À.Þ., Ðîìàíîâà Î.À., ²ãóìíîâà Í.²., Ñèäîðåíêî Ò.À., Þõèìåíêî Â.²., Êîíàðåâà Ê.Ñ. FEATURES OF CELLULAR IMMUNITY IN CHILDREN WITH CHRONIC HERPES VIRUS INFECTION DEPENDING ON THE AGE AND DEGREE OF EXPOSURE TO THE DIFFERENT TYPES VIRUSES VolyanskiyA.Yu., Romanova E.A., Igumnova N.I., Sidorenko T.A., Yuchimenko V.I., Konareva K.S. The basic
parameters of cellular immunity and leukocyte composition of peripheral
blood of children suffering HGVI caused by herpes viruses of I-VI
types, age groups 3-5, 6-11, 12-14 years, corresponding to different
degrees of maturity of immune system, were studed. Regardless of age, a
significant change in the quantity and composition of lymphoid
subpopulations of leukocytes observed in patients with persistent
groups of 3 or more types of herpes viruses in leukocytes. Typical for
these patients all surveyed age groups are lack of cell subpopulations
of T-cytotoxic (CD8+) and T-active (HLA-DR +) lymphocytes and decreased
functional capacity of T-lymphocytes (except for patients 12-14 years
old) as a spontaneous and stimulated PHA blastogenesis. The most
numerous irregularities characterized by cellular immunity HGVI with
younger children (3-5 years). Regardless of the viral load in all
patients 3-5 years, and a group with high viral load is observed 6-11
multiple increase of activated T-lymphocytes (CD25 +) against a
significant reduction of T lymphocyte apoptosis markers (CD3 + CD95 +).
With increasing age of the children with the HGVI, the amount of the
changed parameters of cellular immunity in charge of anti-virus
protection is reduced. Thus more rapid and complete normalization
observed in patients infected with 1-2 herpes viruses.
Key words:HGVI, cellular immunity. |
75-83 |
|
| ÂÏËÈÂ
ÑÒÀÔ²ËÎÊÎÊÎÂί ²ÍÔÅÊÖ²¯ ÍÀ ÑÒÐÓÊÒÓÐÍÓ ÎÐÃÀͲÇÀÖ²Þ ÃÎËÎÂÍÎÃÎ
ÌÎÇÊÓ ÒÀ ÉÎÃÎ ÑÓÄÈÍ Ó ÙÓв ˲Ͳ¯ ²ÑÒÀÐ Â ÅÊÑÏÅÐÈÌÅÍÒ² Òîðÿíèê ².²., Êàçìèð÷óê Â.Â. THE INFLUINCE OF THE STAPHYLOCOCCUS INFECTION TO THE STRUCTURAL ORGANIZATION OF WISTAR RATS BRAIN AND CEREBRAL BLOOD VESSELS Torianik Inna I., Kazmirchuk Victor V. In this article
there are a dates about the influence of the staphylococcus infection
to the structural organization of Wistar rats brain and cerebral blood
vessels in experiment. The purpose of the experiment’s are achieving by
the seding staphylococcus infection means of the characterical
structures of the brain and cerebral blood damages, that similar with
the such in a human in a case of the development of a traditional
clinic pathology. The results are evaluated to character of the
morphological changes (brain cortex and cerebral blood vessels
destructive and degenerative alterations, inflammatory processes).
Key words: staphylococcus infection, structural organization, brain, cerebral blood vessels, Wistar rats, experiment. |
84-87 |
|
| ÄÎÑ˲ÄÆÅÍÍß ÑÏÅÖÈÔ²×Íί ÀÊÒÈÂÍÎÑÒ² ÒÀ ÀÍÒÈ̲ÊÐÎÁÍί IJ¯ ÏÎÐÎØÊÓ ÃÐÈÁÀ ØȯÒÀÊÅ (Lentinus edodes) Áîáðèöüêà Ë.Î., Ïîïîâà Í.Â., Îñîëîä÷åíêî Ò.Ï., Ôåäîðèòåíêî Í.Î. THE STUDY OF IMMUNOMODULATORYAND ANTIMICROBIAL ACTIVITY OF SHIITAKE MUSHROOMS POWDER (Lentinus edodes) BobritskayaL.A., Popova N.V., OsolodchenkoT.P., Fedoritenko N.A. It was found that
Shiitake mushroom powder exhibited immunomodulatory effects and it
could be used in perspective for immunity correction in the complex
therapy for the treatment of various infectious and inflammatory
diseases. It had moderate antimicrobial activity against aerobic
bacteria (Staphylococcus aureus ATCC 26923, Escherichia coli ATCC
25922, Basillus subtilis ATCC 6633), and fungi (Candida albicans ATCC
653/885).
Key words: immunopotentiating activity, shiitake mushroom powder, antibacterial activity |
88-91 |
|
| ÄÎÑ˲ÄÆÅÍÍß
ÇÌ²Í Ð²ÂÍÅÉ ÄÅßÊÈÕ ÖÈÒÎʲͲ ÒÀ SIgA ÏÐÈ Ë²ÊÓÂÀÍͲ ÕÐÎͲ×ÍÎÃÎ
òÏÅÐÒÐÎÔ²×ÍÎÃÎ ÔÀÐÈÍòÒÓ ²Ç ÇÀÑÒÎÑÓÂÀÍÍßÌ ²ÌÓÍÎÊÎÐÅÊÖ²¯ Êîëÿäà Ò.²., Àòò³êîâ Â. ª., Òóïîò³ëîâ Î.Â., Âäîâ³÷åíêî Í.²., Åãîøèíà Â.À. STUDY OF CHANGES IN LEVELS OF SOME CYTOKINES AND SIgA IN CHRONIC HYPERTROPHIC PHARYNGITIS WITH THE USE OF IMMUNOCORRECTION Kolyada T.I., Attikov V.E., Tupotilov A.V., Vdovichenko N.I., Egoshina V.O. Found that in
this pathology is a significant increase in pro-and anti-inflammatory
cytokines in patients due to the predominance of pro-inflammatory
cytokines during exacerbation of chronic inflammation of the lymphoid
tissues of the pharynx . Found that after the standard treatment for
patients with hypertrophic pharyngitis content IFN-γ levels and sIgA in
the oropharyngeal secretions reaches levels of the control group ,
provided intermittent effect in terms of reducing cytokine levels in
the serum of 45 and 90 days after initiation of treatment and partial
restoration of local immunity oropharynx. In a joint application
Derinat and IRS-19 was observed acceleration of restoring the balance
of cellular and humoral immunity, no recurrence of the disease for the
entire period of observation, that the efficiency of treatment of
chronic hypertrophic pharyngitis.
Key words: cytokines, chronic hypertrophic pharyngitis, immunotherapy. |
92-95 |
|
| Íåêðîëîã. Âîëÿíñüêèé Þð³é Ëåîí³äîâè÷ Necrologue. Volyansky Yuri Leonidovich |
96-98 |
|
