Ç̲ÑÒ (Contents)
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C. (P.) |
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Ðåäàêö³éíà ðàäà (Editorial Board) |
1 |
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Çì³ñò (Contents) |
2-4 |
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ÎÃËßÄÈ (REVIEWS) |
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| ÝÊÑÏÅÐÈÌÅÍÒÀËÜÍÛÅ ÈÑÑËÅÄÎÂÀÍÈß ÑÈÍÅÐÃÈÄÍÎÃÎ ÄÅÉÑÒÂÈß ÀÍÒÈÁÈÎÒÈÊÎÂ ( ÎÁÇÎÐ ËÈÒÅÐÀÒÓÐÛ ) Áèðþêîâà Ñ.Â., ßãíþê Þ.À., Áîìêî Ò.Â., Ìàðþùåíêî À.Ì., Áàêóìåíêî À.Â., Ãîðîäíèöêàÿ Í.È., Áîíäàðü À.Â., Òàíàñîâ Ñ.Â. EXPERIMENTAL RESEARCH OF THE SYNERGIC EFFECT OF THE ANTIBIOTICS Birukova S.V., Yahnyuk J.A, Bomko T. V., Maryuschenko A.M, Bakumenko A.V., Gorodnitskaya N.I., Bondar A.V., Tanasov S.V. In this
artycle was shown analization of the literature, in which the result of
the investigate of the synergic effect of the antibiotics was presents.
The mainy mechanism of the synergic effect of the antibiotics was
studied. It was shown the perspective of the direction for the future
researches.
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5-10 |
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| ÃÅÍÅÒÈ×Ͳ ÄÅÒÅÐ̲ÍÀÍÒÈ ×ÈÍÍÈʲ ÏÀÒÎÃÅÍÍÎÑÒ² ²ÍÔÅÊÖ²ÉÍÈÕ ÇÁÓÄÍÈʲ Âîéäà Þ.Â. GENETIC DETERMINANTS OF PATHOGENICITY FACTORS OF INFECTIOUS AGENTS Voyda Y. V. At
present new positions actively discuss in relation to
a role in expressions of virulence by pathogenicity
islands (PAIs), presented the unstable fragments of DNA which
include the discrete genes of virulence and are of importance for
development of pathogens. The majority of PAIs are located on the
chromosome; however, they can also be part of bacterial plasmids,
transposons or bacteriophages. Such PAIs carry
genes, controlling the synthesis of adhesins,
invasins, toxins, modulins, and also genes of
drug-resistance, genes of phage integrases,
transponases etc. Pointed mutations, genetic alterations and
horizontal transference of genes promote appearance of new
pathogens. As a result of exchange of genetic information
the new properties are formed, including virulent, at the family
nonpathogenic bacteria of different taxonomical groups.
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11-14 |
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| ÂËÈßÍÈÅ ÌÈÊÐÎÎÐÃÀÍÈÇÌΠÍÀ ÐÀÇÂÈÒÈÅ ÃÈÏÅÐÏËÀÑÒÈ×ÅÑÊÈÕ ÏÐÎÖÅÑÑΠ ÍÎÑÎÃËÎÒÊÅ Àòòèêîâ Â.Å., Áðóñíèê Ñ.Â., Øóøëÿïèíà Í.Î., Íåñòåðåíêî À.Ì., Êîëÿäà Î.Ì. Êîëÿäà Ò.È. INFLUENCE OF MICROORGANISMS ON THE DEVELOPMENT OF HYPERPLASTIC PROCESSES IN THE NASOPHARYNX Attikov V.E ,Brusnik S.V., Shushlyapina N.O, Nesterenko A.M., Kolyada O. N., Kolyada T.I. The long –
term course of inflammatory processes in nasopharynx is influenced by:
an increasing antibiotic resistance of microorganisms,
detection of causal agents of ENT
diseases with low pathogenic activity
that were given insufficient attention, the growing
influence of anaerobic pathogens in pathogenesis of these states.
The main reason of nasopharynx lymphoid tissue
proliferation is a chronic inflammatory process as
well as microbial antigenic stimulation. The functional
restoration of lymphoid tissue function is achieved by tissue
hyperplasia. In healthy subjects bacterial interference is manifected
by indigenous microflora of highly pathogenic microorganisms. The
microbiological landscape components are: indigenous microflora,
microorganisms of the additional group and transit microflora. In
summary of the review made by the authors, it could be supposed that
hyperplastic processes in nasopharynx should be viewed as the
continuation of productive process due to the immunopathological
changes in course of the chronic infectious and allergic diseases.
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15-19 |
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| ÂÈÄÎÂÅ ÐÎÇÌÀ¯ÒÒß ÁÎÐÅË²É ÒÀ ¯Õ ÇÍÀ×ÅÍÍß Ó ÊÐÀÉÎÂ²É ÏÀÒÎËÎò¯ Êîìàðåíêî Í.Ñ., Âèíîãðàä Í.Î. SPECIES VARIETION OF BORRELIA AND THEIR IMPORTANCE FOR REGIONAL PATHOLOGY Komarenko N.S., Vynograd N.A. Tick-borne
borreliosis| are|appear| the most widespread natural foci|
transmissible diseases in North America and Eurasia. On North America,
where was discovered borrelia, up to 20 ospC-genotypes of B.
burgdorferi sensu stricto circulates, from what at least 4
are pathogenic for a human. In Europe complex B. burgdorferi
sensu lato is presented by five genotypes: B. afzelii, B.
garinii, B. burgdorferi sensu stricto, B. lusitaniae, B. valaisianà,
which are associated with the different types of vertebral owners and
have specific clinical displays, and also a new type B.
miyamotoi is described. In Ukraine is discovered 1811 affected
Lime borreliosis settlements points and circulation of five borrelia
genotypes B. burgdorferi sensu stricto (except of Crimea),
B. afzelii, B. garinii, B. valasiana, A14S had been shown. The
variety of borrelia genotypes complicates of the laboratory
diagnostics, predetermines the substantial differences of clinical
manifestation of diseases, mosaic of the structure of borrelia natural
focus.
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| ÅÊÑÏÅÐÈÌÅÍÒÀËÜͲ
ÐÎÁÎÒÈ (EXPERIMENTAL STUDY) |
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| ÄÎÑ˲ÄÆÅÍÍß ÀÍÒÈÁÀÊÒÅвÀËÜÍÈÕ ÂËÀÑÒÈÂÎÑÒÅÉ ÑÓÁÑÒÀÍÖ²É ËÀ̲ÍÀв¯ Âëàäèìèðîâà ².Ì., Âîëÿíñüêèé Ä.Ë., Êëèñà Ò.Ë., Îñîëîä÷åíêî Ò. Ï., Øòèêåð Ë. Ã., Ãóøèëèê Á.È., Ïàðóñîâà ß.Þ. RESEARCH OF ANTIBACTERIAL PROPERTIES OF SUBSTANCES LAMINARIA Vladimirova I.N., Volyansky D.L., Klisa T.L., Osolodchenko T. P., Shtuker L. G. , Gushilik B.I., Parusova Ya.,Yu. From
references are known thyroid, laxatives, detoxicating, antineoplastic,
immune, anti-inflammatory, reparating properties of monocomponental and
complex drugs of a laminaria. In given article results of the spent
studying of antibacterial properties of a dry extract thallies
laminaria, water-soluble polysaccharides of a laminaria, 30 % spirit
laminaria tinctures (1:5), and also oligosaccharides, allocated with 30
% of tincture, and the water rest received after removal of spirit
ethyl and oligosaccharides from 30 % of tincture are
resulted. 30 %
tincture, oligosaccharides of a laminaria and the water rest, after
removal of spirit ethyl and oligosaccharides have appeared the most
active concerning investigated referential the test-strains of
microorganisms among laminaria substances.
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23-26 |
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| ÄÎÑ˲ÄÆÅÍÍß ÔÎÐÌÓÂÀÍÍß ÐÅÇÈÑÒÅÍÒÍÎÑÒ² ̲ÊÐÎÎÐÃÀͲÇ̲ ÒÀ ÃÐÈÁ²Â ÄΠ˲ÏÎÔ²ËÜÍÈÕ ÔÐÀÊÖ²É ÏÐÅÄÑÒÀÂÍÈʲ ÐÎÄÓ GALIUM L. Êàøïóð Í.Â., Âîëÿíñüêèé À.Þ., Ãîðÿ÷à Î.Â., Êàçì³ð÷óê Â.Â., Êîâàëüîâà À.Ì., ²ëü¿íà Ò.Â. Îñîëîä÷åíêî Ò.Ï., Ïàðóñîâ À.Â. STUDY OF RESISTANCE FORMATION OF MICROORGANISMS AND FUNGI TO LIPOPHILIC FRACTIONS OF REPRESENTATIVES OF GALIUM L. Kashpur N.V., Volaynsky A.Y., Goraychay O.V. , Kasmirchuk V.V., Kovaleva A.M. , Ilina T.V. , Osolodchenko T.P., Parusov A.V. A
resistance formation of test-strains of Staphylococcus aureus ATCC
25923, Escherichia coli ATCC 25922 and Candida albicans ÀÒÑÑ 885-653 to
chloroformic and ethylacetate-ethanolic fractions of Galium verum L.,
Galium dasypodum Klok. and Galium salicifolium Klok. herbs and
reference-preparations – Chlorophyllipt, gentamycine and nistatine has
been studied. It was established, that a sensitivity of microorganisms
to the lipophilic fractions (250 mkg/ml, 500 mkg/ml) decreases more
slowly and in smaller concentrations comparing with reference-
preparations (Hlorofilipt - 500 mkg/ml, Gentamicin - 12,8 mkg/ml).
Results of the experiment testify further promising use of substances
obtained for the formulation of the preparations with direct
pharmacological properties.
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27-34 |
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| ÂÈÂ×ÅÍÍß ×ÓÒËȲÑÒ² ÄÎ ÀÍÒÈÁ²ÎÒÈʲ ÇÁÓÄÍÈʲ ÃͲÉÍÎ-ÇÀÏÀËÜÍÈÕ ÓÑÊËÀÄÍÅÍÜ Ðèìøà Î. Â. DETECTION SENSITIVITY TO ANTIBIOTICS OF PATHOGENS OF PURULENT-INFLAMMATORY COMPLICATIONS Rymsha O.V. This paper
presents the results of bacteriological studies of pathological
material from patients after surgery for benign hypertrophied prostate
gland. Material for the study were - urine intraoperatively removed
tissue of the prostate and prostate secretion. Clinical isolates of
microorganisms were characterized by morphological, of cultural
properties. Also conducted studies selected strains of microorganisms
to 20 antimicrobial drugs
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35-38 |
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| ÑÈÍÒÅÇ
ÄÂÓÕÌÅÐÍÛÕ ÌÅÌÁÐÀÍ, ÍÀÍÎÐÀÇÌÅÐÍÛÕ ÏÎ ÒÐÅÒÜÅÉ ÌÈÊÐÎÑÊÎÏÈ×ÅÑÊÎÉ
ÊÎÎÐÄÈÍÀÒÅ, ÈÇ ÀÑÊÌ ÍÀ ÏÎÂÅÐÕÍÎÑÒÈ ÏËÀÒÈÍÎÂÛÕ ÏÎÄËÎÆÅÊ È ÈÇÓ×ÅÍÈÅ
ÝËÅÊÒÐÎÕÈÌÈ×ÅÑÊÈÕ ÑÂÎÉÑÒ ÈÍÒÅÐÔÅÉÑΠÏÎ ÎÒÍÎØÅÍÈÞ Ê ÀÍÒÈÃÅÍÀÌ
P.AERUGINOSA ÀÒ ÑÑ 27853 Äæåëàëè Â.Â., Âîëÿíñêèé À.Þ., Ìàðòûíîâ À.Â., Îñîëîä÷åíêî Ò.Ï., Ïîõèë Ñ.È., Îâ÷àðåíêî Ñ.Â., Ãëàçóíîâà Ë.È., ×åðíÿåâà Ò.À., Áàëóòà È.Ì. SYNTHESIS OF TWO-DIMENSIONAL NANOSIZED MEMBRANES FOR MICROSCOPIC THIRD COORDINATES FROM ASKM ON THE SURFACE OF PLATINUM STUDY SUBSTRATES AND ELECTROCHEMICAL PROPERTIES OF THESE INTERFACES AGAINST P. AERUGINOSA ANTIGENS ATÑÑ 27 853 Jelali V.V., Volianskii A.Yu., Martynov A.V., Osolodchenko T.P., Pokhyl S.I., Ovchareko S.V.., Glazunova L.I., Chernyayeva T.A., Baluta I.M. A
high-speed measuring and computing PC-controlled complex has been
created, and its application in registration of cyclic voltage-current
characteristics (CVCC) has been tested. Synthesis of two-dimensional
membranes, nano-sized by the third microscopic coordinate, from
fragments of mouse serum antibodies (MSA) has been performed on the
surface of indifferent metal electrodes. All measured CVCCs from the
Pt/x NANO IM MSA/PBS interface, where x is a number of antibody
monomolecular layers applied on the Pt substrate, have been shown to be
located inside CVCCs from Pt/PBS interface. The study shows that the
CVCC produced from Pt/2 NANO IM MSA/PBS interface is located inside the
CVCC produced from the interface Pt/2 NANO IM MSA/ y ml P. aeruginosa
AT CC 27853 in PBS. Nanobiosensor has been constructed, and
electrochemical method for registration of P. aeruginosa ATCC 27853
complementary antigens in laboratory conditions has been developed in
this study.
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39-45 |
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| ÂËÈßÍÈÅ
ÊÑÀÔÓÁÅÍÀ ÍÀ ÀÊÒÈÂÍÎÑÒÜ ÏÐÎÒÅÎËÈÒÈ×ÅÑÊÈÕ ÔÅÐÌÅÍÒΠÊÈÍÈÍÎÂÎÉ ÑÈÑÒÅÌÛ È
ÑÎÄÅÐÆÀÍÈÅ ÏÐÎÑÒÀÃËÀÍÄÈÍÎÂ ÃÐÓÏÏÛ ÏÃÅ1 Â ÏËÀÇÌÅ ÊÐÎÂÈ Êèðååâ È.Â., Ñàìóðà Á.À., Ëèòâèíîâà Î.Í., Âîëêîâîé Â.À. INFLUENCEOF XANBUFEN ON ACTIVITY PROTEOLYTIC ENZYMES OF KININIC SYSTEM AND CONTENTS OF PROSTAGLANDINUMS PGE1 IN BLOOD PLASMA Kireyev I.V., Samura B.À., Litvinova Î.N., Volkovoy V.A. The
influence of xanfuben on activity proteolytic enzymes of kininic system
and contents of prostaglandinums is investigated. Fixed, that xanfuben
inhibits process kininogenesis and, as against Acidum
Acetylsalicylicum, prevents expenditure of components
kallikrein-kininic system, and also reduces contents of
prostaglandinums by 63,3 % in comparison with experimental rats with
carragenin’s edema of pad. Obtained results allow to recommend xanfuben
for further study of activity and safety for working up medications for
treatment painful and inflammatory signs of various etiology
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46-49 |
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| ²ñòîð³ÿ íàóêè (History of science) |
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| ÕÀÐÜÊÎÂÑÊÎÌÓ ÌÅÄÈÖÈÍÑÊÎÌÓ ÎÁÙÅÑÒÂÓ – 150 ËÅÒ Ãàëóøêà Ð.À., Êó÷ìà È.Þ, Ãëàçóíîâà Ë.È., Ìîéñååíêî Ò.Â. TO KHARKOV MEDICAL SOCIETY – 150 YEARS Galushka R.A., Kukhma I.Yu., Glazunova L.I., Moiseenko T.V. The article is devoted history of formation of Kharkov medical society and his creators.
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50-55 |
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| Þâ³ëåé (Anniversary) |
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| Äî 75-ð³÷÷ÿ ïðîôåñîðà ÃÎÐÄ²ß Ê²ÍÄÐÀÒÎÂÈ×À ÏÀË²ß |
52-53 |
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