Annals of Mechnikov's Institute 2011 3
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Contents)



C. (P.)


(Editorial Board)

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(Contents)

2-4

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(REVIEWS)



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EXPERIMENTAL RESEARCH OF THE SYNERGIC EFFECT OF THE ANTIBIOTICS
Birukova S.V., Yahnyuk J.A, Bomko T. V., Maryuschenko A.M, Bakumenko A.V., Gorodnitskaya N.I., Bondar A.V., Tanasov S.V.
In this artycle was shown analization of the literature, in which the result of the investigate of the synergic effect of the antibiotics was presents. The mainy mechanism of the synergic effect of the antibiotics was studied. It was shown the perspective of the direction for the future researches.


5-10

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GENETIC DETERMINANTS OF PATHOGENICITY FACTORS OF INFECTIOUS AGENTS
Voyda Y. V.
At present  new positions actively  discuss  in relation to a role in expressions of virulence   by pathogenicity islands  (PAIs), presented the unstable fragments of DNA which include the discrete genes of virulence and  are of importance for development of pathogens. The majority of PAIs are located on the chromosome; however, they can also be part of bacterial plasmids, transposons or bacteriophages.  Such  PAIs  carry genes,  controlling  the  synthesis of  adhesins, invasins, toxins,  modulins, and also genes of  drug-resistance, genes of  phage  integrases,  transponases  etc. Pointed mutations, genetic alterations and horizontal transference of genes promote appearance  of new pathogens. As a result of  exchange  of genetic information the new properties are formed, including virulent, at the family  nonpathogenic bacteria of different taxonomical groups.

11-14

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INFLUENCE OF MICROORGANISMS ON THE DEVELOPMENT OF HYPERPLASTIC PROCESSES IN THE NASOPHARYNX
Attikov V.E ,Brusnik S.V., Shushlyapina N.O, Nesterenko A.M., Kolyada O. N., Kolyada T.I.
The long term course of inflammatory processes in nasopharynx is influenced by: an increasing antibiotic resistance of  microorganisms,  detection  of  causal  agents  of  ENT  diseases  with  low  pathogenic  activity  that  were  given insufficient attention, the growing influence of anaerobic pathogens in pathogenesis of these states.  The  main reason of nasopharynx  lymphoid tissue  proliferation is a chronic  inflammatory process  as  well as microbial  antigenic stimulation. The functional restoration of lymphoid tissue function is achieved by tissue hyperplasia. In healthy subjects bacterial interference is manifected by indigenous microflora of highly pathogenic microorganisms.  The microbiological landscape components are: indigenous microflora, microorganisms of the additional group and transit microflora. In summary of the review made by the authors, it could be supposed that hyperplastic processes in nasopharynx should be viewed as the continuation of productive process due to the immunopathological changes in course of the chronic infectious and allergic diseases.

15-19

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SPECIES VARIETION OF BORRELIA AND THEIR IMPORTANCE FOR REGIONAL PATHOLOGY
Komarenko N.S., Vynograd N.A.
Tick-borne borreliosis| are|appear| the most widespread natural foci|  transmissible diseases in North America and Eurasia. On North America, where was discovered borrelia, up to 20 ospC-genotypes of B. burgdorferi  sensu  stricto circulates, from what at least 4 are pathogenic for a human. In Europe complex B. burgdorferi  sensu  lato is presented by five genotypes: B. afzelii, B. garinii, B. burgdorferi sensu stricto, B. lusitaniae, B. valaisian, which are associated with the different types of vertebral owners and have specific clinical displays, and also a new type B.  miyamotoi  is described. In Ukraine is discovered 1811 affected Lime borreliosis settlements points and circulation of five borrelia genotypes B. burgdorferi  sensu stricto  (except of Crimea), B. afzelii, B. garinii, B. valasiana, A14S  had been shown. The variety of borrelia genotypes complicates of the laboratory diagnostics, predetermines the substantial differences of clinical manifestation of diseases, mosaic of the structure of borrelia natural focus.
 


20-22

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(EXPERIMENTAL STUDY)



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RESEARCH OF ANTIBACTERIAL PROPERTIES OF SUBSTANCES LAMINARIA
Vladimirova I.N., Volyansky D.L.,  Klisa T.L., Osolodchenko T. P., Shtuker  L. G. , Gushilik B.I., Parusova Ya.,Yu.
From references are known thyroid, laxatives, detoxicating, antineoplastic, immune, anti-inflammatory, reparating properties of monocomponental and complex drugs of a laminaria. In given article results of the spent studying of antibacterial properties of a dry extract thallies laminaria, water-soluble polysaccharides of a laminaria, 30 % spirit laminaria tinctures (1:5), and also oligosaccharides, allocated with 30 % of tincture, and the water rest received after removal of spirit ethyl and oligosaccharides from 30 % of tincture are resulted.          30 % tincture, oligosaccharides of a laminaria and the water rest, after removal of spirit ethyl and oligosaccharides have appeared the most active concerning investigated referential the test-strains of microorganisms among laminaria substances.

23-26

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˲ Ҳ ̲Ͳ̲ ˲Բ ֲ ʲ GALIUM L.
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STUDY OF RESISTANCE FORMATION OF MICROORGANISMS AND FUNGI TO LIPOPHILIC FRACTIONS OF REPRESENTATIVES OF GALIUM L.
Kashpur N.V., Volaynsky A.Y., Goraychay O.V. , Kasmirchuk V.V., Kovaleva A.M. , Ilina T.V. , Osolodchenko T.P., Parusov A.V.
A resistance formation of test-strains of Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Candida albicans 885-653 to chloroformic and ethylacetate-ethanolic fractions of Galium verum L., Galium dasypodum Klok. and Galium salicifolium Klok. herbs and reference-preparations Chlorophyllipt, gentamycine and nistatine has been studied. It was established, that a sensitivity of microorganisms to the lipophilic fractions (250 mkg/ml, 500 mkg/ml) decreases more slowly and in smaller concentrations comparing with reference- preparations (Hlorofilipt - 500 mkg/ml, Gentamicin - 12,8 mkg/ml). Results of the experiment testify further promising use of substances obtained for the formulation of the preparations with direct pharmacological properties.
 

27-34

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DETECTION SENSITIVITY TO ANTIBIOTICS OF PATHOGENS OF PURULENT-INFLAMMATORY COMPLICATIONS
Rymsha O.V.
This paper presents the results of bacteriological studies of pathological material from patients after surgery for benign hypertrophied prostate gland. Material for the study were - urine intraoperatively removed tissue of the prostate and prostate secretion. Clinical isolates of microorganisms were characterized by morphological, of cultural properties. Also conducted studies selected strains of microorganisms to 20 antimicrobial drugs
 
35-38

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, , P.AERUGINOSA 27853
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SYNTHESIS OF TWO-DIMENSIONAL NANOSIZED MEMBRANES FOR MICROSCOPIC THIRD COORDINATES FROM ASKM ON THE SURFACE OF PLATINUM STUDY SUBSTRATES AND ELECTROCHEMICAL PROPERTIES OF THESE INTERFACES AGAINST P. AERUGINOSA ANTIGENS AT 27 853
Jelali V.V., Volianskii A.Yu., Martynov A.V., Osolodchenko T.P., Pokhyl S.I., Ovchareko S.V.., Glazunova L.I., Chernyayeva T.A., Baluta I.M.
A high-speed measuring and computing PC-controlled complex has been created, and its application in registration of cyclic voltage-current characteristics (CVCC) has been tested. Synthesis of two-dimensional membranes, nano-sized by the third microscopic coordinate, from fragments of mouse serum antibodies (MSA) has been performed on the surface of indifferent metal electrodes. All measured CVCCs from the Pt/x NANO IM MSA/PBS interface, where x is a number of antibody monomolecular layers applied on the Pt substrate, have been shown to be located inside CVCCs from Pt/PBS interface. The study shows that the CVCC produced from Pt/2 NANO IM MSA/PBS interface is located inside the CVCC produced from the interface Pt/2 NANO IM MSA/ y ml P. aeruginosa AT CC 27853 in PBS. Nanobiosensor has been constructed, and electrochemical method for registration of P. aeruginosa ATCC 27853 complementary antigens in laboratory conditions has been developed in this study.

39-45

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INFLUENCEOF XANBUFEN ON ACTIVITY PROTEOLYTIC ENZYMES OF KININIC SYSTEM AND CONTENTS OF PROSTAGLANDINUMS PGE1 IN BLOOD PLASMA
Kireyev I.V., Samura B.., Litvinova .N., Volkovoy V.A.
The influence of xanfuben on activity proteolytic enzymes of kininic system and contents of prostaglandinums is investigated. Fixed, that xanfuben inhibits process kininogenesis and, as against Acidum Acetylsalicylicum, prevents expenditure of components kallikrein-kininic system, and also reduces contents of prostaglandinums by 63,3 % in comparison with experimental rats with carragenins edema of pad. Obtained results allow to recommend xanfuben for further study of activity and safety for working up medications for treatment painful and inflammatory signs of various etiology

46-49

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(History of science)



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TO KHARKOV MEDICAL SOCIETY 150 YEARS
Galushka R.A., Kukhma I.Yu., Glazunova L.I., Moiseenko T.V.
The article is devoted history of formation of Kharkov medical society and his creators.

50-55

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(Anniversary)



75-
IJ ʲ ˲


52-53

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