LABORATORY OF IMMUNOREHABILITOLOGY

 

Head of the Laboratory

 

Andrey Volyanskiy

MD, Ph.D., D.Hab.

  Scientific direction

Currently, the laboratory is accumulating fundamentally new information on the role of infectious agents, particularly herpesvirus, in general human pathology, the logical conclusion of which is expected to result in the development of a new concept of the role and importance of persistent intracellular infections both in general human pathology and in adaptive capacity of the body under physiological conditions of existence.

The considerable expansion of infectious diseases requires the formation of a new paradigm of herpesvirus infection, primarily due to establishment of the role of herpesvirus in the course of diseases previously considered as non-infectious, and definition of their aggravating influence on the course of human chronic diseases, which is accompanied by deviation in immunological homeostasis, because despite differences in etiology, pathogenesis, clinic, morphological nature and consequences, all diseases are combined by a single common immunopathological mechanism.

  STAFF

  1. Andrii Volianskyi – head of the Laboratory, MD, Ph.D., D.Hab.;
  2. Maiia Smilianska - MD, Ph.D., leader researcher (head of immunology and virology division);
  3. Nataliia Kashpur- M. Sc. (Biology), Ph.D., senior researcher;
  4. Tatyana Davidova - MD, Ph.D., senior researcher;
  5. Igor Yudin - MD, Ph.D., senior researcher;
  6. Maksym Kuchma - MD,Ph.D., junior researcher;

Maya Smelyanskaya
MD, Ph.D., leader researcher (head of immunology and virology division)

Igor Yudin
MD, Ph.D., senior researcher

Natalia Kashpur
M. Sc. (Biology), Ph.D., leader researcher

Maksym Kuchma
MD, Ph.D., junior researcher

Tetiana Davidova
MD, Ph.D., senior researcher

Lyuba Chernova
laboratory assistant

  Topics of the laboratory

1. «Immunological, virologic, clinical aspects of arrhythmogeneses in young people with idiopathic arrhythmia» NAMS 142/2018;

2. «Determination of individual features of immune response immune responses to vaccination for the personification of vaccine prophylaxis in preschool children» NAMS 143/2018;

3. Initiative theme «Features of the flow of measles outbreak in the Kharkiv region in 2017-2019»;

LABORATORY OF IMMUNOREHABILITOLOGY

  Monograph

  • Volyansky A. Y. Features of the formation of vaccinal immunity after routine vaccination of children with chronic herpesvirus infection / A. Y. Volyansky, M. V. Smelyanskaya, S. D. Peremot, N. V. Kashpur, M. V. Kuchma // Collective monograph «Development and modernization of medical science and practice: experience of Poland and prospects of Ukraine». – Poland. – 2017. – V. 3. – P. 124 – 139.
  • Peremot S. D. Imbalance in the cytokine system in herpesviral myocarditis / S. D. Peremot, A. Y. Volyansky, M. V. Smelyanskaya, N. V. Kashpur // Collective monograph «Development and modernization of medical science and practice: experience of Poland and prospects of Ukraine». – Poland. – 2017. – V. 3. – P. 192 – 208.
  • Mechanisms of prokaryote genome variability / Ed. Volianskii Yu.; Kuchma I., Kolotova T., Shyrobokov V., Volianskii A., Palii G., Stegnii M., Iankovskii D. – Kharkov: NTMT, 2011. – 319 p.

  Diplomas

  • Diploma of the Presidium of the Academy of Medical Sciences of Ukraine, for the best research work completed in 2001 "Herpes viruses (HSV1, HSV2, TsMV) in the process of atherogenesis: virological, immunological, clinical parallels" (TF 4.30.99), research supervisor c.med. ., Smelyanskaya M.V.
  • Diploma of the Presidium of the Academy of Medical Sciences of Ukraine, for the best research work completed in 2011 "The effect of immunological imbalance on the course of acute coronary syndrome in patients with persistent herpes virus infection" (AMN 89/2009; state registration number 0108U001295)
  • Silver diploma of the XVI International Scientific and Practical Conference "Problems and ways of modern public health development" held in the period from December 21 to 26 2011 in London in the framework of the preliminary programme of the project of International Academy of Sciences and Higher Education "World Championship, continental, national and regional research analytics championships".
  • Biologically active substances of lipophilic fractions of herbs of genera Artemisia L., Potentilla L., Melilotus L. and research of their antimicrobial activity. Ochkur A., Kashpur N., Kovalyova A. – 2011. – P. 437-443.

  Publications

  1. Volianskyi A. Yu. Comparison of the immunogenicity and protein composition of experimental and official virosomal influenza vaccines / A. Yu. Volianskyi, S. S. PogorIla, O. A. Romanova, T. V. Davidova, A. V. Martinov, N. I. Igumnova, T. A. Sidorenko, V. I. Yuhimenko, S. D. Peremot, M. V. Smilianska, N. V. Kashpur // Annals of Mechnikov's Institute. -2014. - № 3. – Р. 13 – 18
  2. Goryacha O. V. The antibacterial activity of lipophilic complexes from Bedstrows against microorganisms of Enterobacteriaceae family / O. V. Goryacha, N. V. Kashpur, Т. V. Іlyinа, А. М. Коvаlyоvа // Сlinical pharmacy. – 2014. - Т. 18, № 4. – Р. 49-51.
  3. Kashpur N. V. The immunomodulatore effect of Asperula odorata L. and Asperula humifusa M, Bieb. Besser dry extracts / N. V. Kashpur, N. S. Yurchenko, Т. V. Іlyinа, А. М. Коvаlyоvа, O. V. Goryacha // Сlinical pharmacy. – 2015. – Т. 19, № 1. – Р. 56 – 58.
  4. Smilianska M. V. The effectiveness of methods for laboratory diagnosis of viral myocarditis / M. V. Smilianska, S. D. Peremot, N. V. Kashpur, A. Yu. Volianskyi // Materials of the scientific-practical conference with international participation "Medicine of the XXI century: prospects and priority directions of scientific research". - Dnepropetrovsk. – 2015. – P. 79 – 84.
  5. Smilianska M. V. Etiological landscape of viral myocarditis of the Kharkiv region / M. V. Smilianska, S. D. Peremot, N. V. Kashpur // Materials of the scientific-practical conference with international participation "Modern medicine: actual problems, solutions and prospects for development". – Odesa. – 2015. – P. 69 – 73.
  6. Volianskyi A. Yu. The state of general immunity in preschool children with chronic herpes virus infections / A. Yu. Volianskyi, M. V. Smilianska, E. S. Konoreva // Proceedings of the international scientific-practical conference "Actual achievements of medical scientific research in Ukraine and neighboring countries". - Kiev. – 2015. – P. 47 – 50.
  7. Peremot S. D. The prevalence of infection with herpes viruses of children in a closed group / S. D. Peremot, K. S. Konareva, M. V. Kuchma // Proceedings of the international scientific-practical conference "Modern medicine: current issues". - Odesa. – 2015. – P. 48 – 52.
  8. Volianskyi A. Yu. The state of general immunity in preschool children with HGVI / A. Yu. Volianskyi, K. S. Konareva, M. V. Kuchma // Materials of the international scientific-practical conference. - Lviv. – 2016. – P. 46 – 48.
  9. Volianskyi A. Yu. Impact of herpes virus infection on the immune system and the body’s immune response to vaccination / A. Yu. Volianskyi, M. V. Kuchma, T. Yu. Kolotova, T. L. Klysa, I. Yu. Kuchma, E. S. Konoreva, M. V. Smilianska, S. D. Peremot, N. V. Kashpur, M. B Davidenko // Annals of Mechnikov's Institute. – 2016. – № 3. – P. 31 – 44. URL: http://www.imiamn.org. ua/journal /3_2016/PDF/6.pdf
  10. Smilianska M. V. Features of the immune status of children with chronic herpes virus infection after routine vaccination // M. V. Smilianska, S. D. Peremot, N. V. Kashpur, Volianskyi A. Yu. // Medical Forum. – 2016. – № 9. P. 83 – 86.
  11. Kashpur N. V. The dynamics of infection of children depending on the age of the viruses family Herpesviridae / N. V. Kashpur, M. V. Smilianska, S. D. Peremot // Proceedings of the international scientific-practical conference "New in the medicine of the modern world". – Lviv. – 2016. – P. 27 - 30.
  12. Volianskyi A. Yu. The nature of changes in cytokines in the status of children with chronic herpes virus infection in the post-vaccination period / A. Yu. Volianskyi, I. Yu. Kuchma, M. V. Kuchma // Proceedings of the international scientific-practical conference "Modern trends in medical and pharmaceutical sciences". – Kiev. – 2016. – P. 47-51.
  13. Smilianska M. V. Infection of children of different ages with viruses of the Herpesviridae family / M. V. Smilianska, M. V. Kuchma, K. S. Konoreva // Materials of the scientific-practical conference with international participation "Mechnikovsky reading - 2016. Actual problems of parenteral infections". - Kharkiv. – 2016. – P. 132–133.
  14. Volianskyi A. Yu. Determination of the intensity of vaccine immunity in routine vaccination of children with chronic herpes infection / A. Yu. Volianskyi, M. V. Kuchma, K. S. Konoreva // Materials of the scientific-practical conference with international participation "Mechnikovsky reading - 2016. Actual problems of parenteral infections". - Kharkiv. – 2016. – P. 37–38.
  15. Volianskyi A. Yu. Cytokine status of children with the persistence of viruses of the Herpesviridae family depending on the viral load / A. Yu. Volianskyi, T. L. Klysa, K. S. Kushnir, M. V. Kuchma // Proceedings of the international scientific-practical conference "Domestic and world medicine: the requirements of the present". – Dnipro. – 2016. – P. 65 –67.
  16. Smilianska M. V. The use of the chemiluminescence metod to evaluate the oxygen metabolism of blood neutrophils in children with chronic herpesvirus infection after routine vaccination / M. V. Smilianska, S. D. Peremot, N. V. Kashpur, A. Y. Volianskyi // Materials of the international scientific-practical conference "Achievements and prospects in the fight against infectious diseases (microbiology, veterinary medicine, pharmacy)". - Kharkiv. – 2017. – P. 84 - 85.
  17. Volianskyi A. Yu. Content of cytokines of the Th 1 profile (IFNγ and IL-2) and cytokines of the Th 2 profile (IL-4 and IL-10) in children with chronic herpes virus infection in the post-vaccination period / A. Yu. Volianskyi, S. D. Peremot, M. V. Smilianska, N. V. Kashpur, M. V. Kuchma // Materials of the international scientific-practical conference "Achievements and prospects in the fight against infectious diseases (microbiology, veterinary medicine, pharmacy)". – Kharkiv. – 2017. – P. 94 - 95.
  18. Smilianska M. V. Assessment of the main parameters of the neutrophilic phagocytosis link in children with chronic herpes virus infection after routine vaccination / M. V. Smilianska, S. D. Peremot, N. V. Kashpur, A. Y. Volianskyi // International research and practice conference «Innovative technology in medicine: experience of poland and ukraine». – Lublin, Republic of Poland. – 2017. – P. 90 - 94.
  19. Volianskyi A. Y. Features of the formation of vaccine immunity after routine vaccination of children with chronic herpes virus infection / A. Y. Volianskyi, M. V. Smilianska, S. D. Peremot, N. V. Kashpur // Medical Forum. – 2017. – № 11. – P. 22 – 26.
  20. Smilianska M. V. Accumulation at the children of T-that V-klіtin memory in the post-vaccination period / M. V. Smilianska, V. M. Pavlova, L. O. Kuzik, T. P. Didorenko // Proceedings of the international scientific-practical conference "Features of the modernization of the subject of research representatives of medical sciences". - Kiev. – 2017. – P. 88 - 91.
  21. Volianskyi A. Y. Dynamics of accumulation of T-and B-cells of memory in children with chronic herpes virus infection after immunization of ADS and PDA with vaccines / A. Y. Volianskyi, M. V. Smilianska, S. D. Peremot, N. V. Kashpur, M. V. Kuchma // Mathematical, scientific and practical conference "Methodical science and practice: relevance in Ukraine". - Kiev. – 2017. – P. 53 - 57.
  22. Volianskyi A. Y. Features of the formation of vaccinal immunity after routine vaccination of children with chronic herpesvirus infection / A. Y. Volianskyi, M. V. Smilianska, S. D. Peremot, N. V. Kashpur, M. V. Kuchma // Collective monograph «Development and modernization of medical science and practice: experience of Poland and prospects of Ukraine». – Poland. – 2017. – V. 3. – P. 192 – 208.
  23. Smilianska M. V. Specific immunity against mumps in preschool children in Kharkiv in 2018 / M. V. Smilianska, A. Yu. Volianskyi, S. D. Peremot, N. V. Kashpur, A. O. Klysa, M. V. Kuchma // Proceedings of the international scientific-practical conference "Modern scientific research of representatives of medical science - the progress of medicine of the future." - Kiev. – 2018. – P. 72 - 78.
  24. Smilianska M. V. The state of immunity to rubella in preschool children of Kharkiv / M. V. Smilianska, A. Yu. Volianskyi, S. D. Peremot, N. V. Kashpur, A. O. Klysa, M. V. Kuchma // Materials of the international scientific-practical conference "The modern dimension of medical science - and practice." - Dnipro. – 2018. – P. 96 - 101.
  25. Smilianska M. V. The level of specific immunity against measles in preschool children of Kharkov. In 2018 / M. V. Smilianska, A. Yu. Volianskyi, S. D. Peremot, N. V. Kashpur, A. O. Klysa, M. V. Kuchma // International research and practice conference «The development of medical sciences: problems and solutions». – Brno, Czech Republic. – 2018. – Р. 161 - 166.
  26. Volianskyi A. Y. Is measles elimination inevitable? / A. Y. Volianskyi // Clinical Infectology and Parasitology. – 2018. – Т. 7, № 1. – P. 8–13.
  27. Smilianska M. V. Disbalance of specific immune response and hervesvirus percistence in children / M. V. Smilianska // International multidisciplinary conference «Key issues of education and sciences: development prospects for Ukraine and Poland». –Stalowa Wola, Republic of Poland. – 2018. – V. 6. – Р. 57 - 60.
  28. Golubovskaya O. A. Measles in Ukraine: features of vaccine prevention during the epidemic period / O. A. Golubovskaya, A. Yu. Volianskyi // Clinical Infectology and Parasitology. – 2018. – № 2. – P. 162-165.
  29. Smilianska M. V. The state of population measles immunity on the background of the epidemic rise in measles in Ukraine in 2017–2018 gg / M. V. Smilianska, I. P. Yudin, M. V. Kuchma, O. A. Golubovskaya, O. A. Podolyuk // Clinical Infectology and Parasitology. – 2018. – № 2. – P. 166-171.
  30. Smilianska М.V. Еffect of herpesvirus persistence on the formation of a specific immune response in children [Electronic resource] / М. V. Smilianska, А. Y. Volianskyi, S. D. Peremot, N. V. Kashpur, A. A. Klysa, T. L. Klysa, M. V. Kuchma // Annals of Mechnikov's Institute. - 2018. - № 3. – Р. 52-56. www.imiamn.org.ua/journal.htm.
  31. Smilianska М.V. New paradigm in vaccinology from individual level to population public health / M. V. Smilianska, A. Yu. Volianskyi, S. D. Peremot, N. V. Kashpur, A. O. Klysa // Medical Forum. – 2018. – P. 67 - 71.
  32. Smilianska M. V. Specific antiherpetic immunity in patients with infectious myocarditis / M. V. Smilianska, S. D. Peremot, N. V. Kashpur // Materials of the international scientific-practical conference with international participation "Actual achievements of medical scientific research in Ukraine and neighboring countries." - Kiev. – 2015. – P. 79 – 83.
  33. Smilianska M. V. Etiological nature of infectious myocarditis according to endomyocardial biopsy data / M. V. Smilianska, S. D. Peremot, N. V. Kashpur // Materials of the international scientific-practical conference with international participation "Actual issues of modern medicine: scientific discussions." - Lviv. – 2015. – P. 100 – 103.
  34. Peremot S. D. The role of herpes viruses in the paradigm of infectious myocarditis / S. D. Peremot, M. V. Smilianska, A. Yu. Volianskyi, N. V. Kashpur // Annals of Mechnikov's Institute. – 2016. – № 1. – P. 48–55. URL: http://www.imiamn.org.ua/journal/1_2016/zmist1_2016.html
  35. Smelyanskaya M. V. Еtiologic factor in the development of myocarditis in the kharkiv region / M. V. Smelyanskaya, S. D. Peremot, N. V. Kashpur // Annals of Mechnikov's Institute. – 2016. – № 3. – P. 45–48. URL: http://www.imiamn.org.ua/journal/1_2016/zmist1_2016.html
  36. Peremot S. D. The disbalance of cytokines in herpesvirus myocarditis / S. D. Peremot, M. V. Smelyanskaya, N. V. Kashpur // Annals of Mechnikov's Institute. – 2016. – № 4. – P. 40 – 45. URL: http://http://www.imiamn. org.ua/journal/4_2016/PDF/7.pdf.
  37. Kashpur N. V. Comparative analysis of the results of the detection of herpes viruses in pathoanatomical material with the fatal consequences of infectious myocarditis / N. V. Kashpur, M. V. Smilianska, S. D. Peremot, A. Yu. Volianskyi, // Materials of the scientific-practical conference "Priority areas for solving urgent problems of medicine." – Dnepr. – 2016. – P. 27–33.
  38. Kashpur N. V. Detection of herpesvirus in pathoanatomical material at fatal cases of viral myocarditis / N. V. Kashpur, M. V. Smelyanskaya, S. D. Peremot // Materials of the international scientific-practical conference "Priority scientific directions in medicine: from theory to practice." - Odesa. – 2016. – P. 51–54.
  39. Volianskyi A. Y. Cytokine imbalance in patients with herpes virus myocarditis / A. Y. Volianskyi, M. V. Smilianska, S. D. Peremot, N. V. Kashpur, M. V. Kuchma // Materials of the scientific-practical conference with international participation "Mechnikovsky reading - 2016. Actual problems of parenteral infections." - Kharkiv. – 2016. – P. 39–40.
  40. Smelyanskaya M. V. Molecular biological research at fatal consequences of viral myocarditis / M. V. Smelyanskaya, S. D. Peremot, N. V. Kashpur, A. Y. Volyansky // Annals of Mechnikov's Institute. – 2017. – № 1. – P. 39 – 43. URL: http://www.imiamn.org.ua/journal/1_2017/PDF/8.pdf
  41. Peremot S. D. Integral cytokine imbalance in viral myocarditis / S. D. Peremot, M. V. Smilianska, A. Yu. Volianskyi, N. V. Kashpur // Materials of the international scientific-practical conference "Methodical science and practice: current issues of interaction." - Kiev. – 2017. – P. 68 - 73.
  42. Peremot S. D. Immunorehabilitation herpes virus myocarditis / S. D. Peremot, M. V. Smilianska, N. V. Kashpur // Materials of the international scientific-practical conference "Priority scientific directions in medicine: from theory to practice." - Odesa. – 2017. – P. 72 - 78.
  43. Peremot S. D. Іntegral evaluation of the cytokine system in viral myocarditis / S. D. Peremot, A. Y. Volyansky, M. V. Smelyanskaya, N. V. Kashpur, I. P. Yudin, T. L. Klysa // Annals of Mechnikov's Institute. - 2017. - № 3. – Р. 56 – 61. .URL: http://www.imiamn.org.ua/journal/3_2017/PDF/9.pdf.
  44. Peremot S. D. Cytokine imbalance in herpes virus myocarditis / S. D. Peremot, M. V. Smilianska, A. Yu. Volianskyi, N. V. Kashpur // Collective monograph «Development and modernization of medical science and practice: experience of Poland and prospects of Ukraine». – Poland. – 2017. – V. 3. – P. 124 – 139.
  45. Peremot S. D. Latent inflammation as a possible factor of arrhythmogenesis in “idiopathic” gastric arrhythmias / S. D. Peremot, M. V. Smilianska, A. Yu. Volianskyi, N. V. Kashpur, A. O. Klysa // Proceedings of the international scientific-practical conference "The modern dimension of medical science - and practice." – Dnipro. – 2018. – P. 61 - 67.
  46. Peremot S. D. Immunological aspects of idiopathic ventricular arrhythmias / S. D. Peremot, M. V. Smilianska, A. Yu. Volianskyi, N. V. Kashpur, T. L. Klysa // International research and practice conference «The development of medical sciences: problems and solutions». – Brno, Czech Republic. – 2018. – Р. 24 - 28.
  47. . Peremot S. D. Clinical aspects of idiopathic ventricular arrhythmia / S. D. Peremot // International multidisciplinary conference «Key issues of education and sciences: development prospects for Ukraine and Poland». –Stalowa Wola, Republic of Poland. – 2018. – V. 6. – Р. 49 - 52.
  48. Peremot S. D. Analysis of clinical and laboratory markers of electrical instability of the heart without structural damage / S. D. Peremot, M. V. Smilianska, A. Yu. Volianskyi, N. V. Kashpur, A. O. Klysa // Materials of the international scientific-practical conference "Medical science and practice: current issues of interaction." - Kiev. – 2018. – P. 42 - 47.
  49. Peremot S. D. Сlinical and immunological aspects of electrical instability of a structurally unchanged heart / S. D. Peremot, А. Y. Volianskyi, М. V. Smilianska, N. V. Kashpur, A. A. Klysa, T. L. Klysa // Annals of Mechnikov's Institute. - 2018. - № 3. – Р. 15-18. www.imiamn.org.ua/journal.htm.
  50. Peremot S. D. Inflammatory markers for idiopathic arrhythmias /S.D. Peremot, А. Y. Volianskyi, М. V.Smilianska //Proceedings of the Second International Conference of European Academy of Science . -Bonn, Germany, November 20-28, 2018, P. 54.
  51. Sectoral (biomedical) innovations: Method for determining the functional activity of lymphocytes (PAL) using an Agilent 2100 bioanalyzer / A. Y. Volianskyi, M. V. Smilianska, S. D. Peremot, N. V. Kashpur, I. P. Yudin // Newsletter of the National Academy of Medical Sciences of Ukraine (supplement to the "Journal of the National Academy of Medical Sciences of Ukraine"). - 2018. - Vol. 45.
  52. Sectoral (biomedical) innovations: A method for increasing the multiplicity of viral antigens (VA) and DNA in blood lymphocytes (LK) / A. Y. Volianskyi, M. V. Smilianska, S. D. Peremot, N. V. Kashpur, I. P. Yudin // Newsletter of the National Academy of Medical Sciences of Ukraine (supplement to the "Journal of the National Academy of Medical Sciences of Ukraine"). - 2018. - Vol. 45.

LABORATORY OF IMMUNOREHABILITOLOGY

  Patents

  • Publication number: UA 55618, IPC A61B5/021; G01N33/53 / Method for prognosing of risk of acute coronary syndrome in patients with coronary heart disease, infected with viruses of the family Herpesviridae / Volianskyi A., Kuchma I., Peremot S., Kashpur N., Sydorenko T., Smilianska M. /аpplication number: u201003571 from 29.03.2010; рublication date: 27.12.2010; newsletter № 24, 2010.
  • Publication number: UA 99042, IPC A61K 36/74 (2006.01), A61K 135/00 (2006.01), A61P 31/04 (2006.01) / Process for the preparation of lipophilic complex of antimicrobic action / Goncharov N., Kovaliova A., Iliina T., Kashpur N. /аpplication number: а2011_02084 from 22.02.2011; рublication date: 10.07.2012; newsletter № 13, 2012.
  • Publication number: UA 104173, IPC A61K 36/282 (2006.01), A61P 31/00 / Method for producing product with antimicrobial activity from plant raw materials / Ochkur O., Kashpur N., Honcharov N., Kovaliova A., Iliina T. /аpplication number: u2011 12754 from 31.10.2011; рublication date: 10.01.2014; newsletter № 1, 2014.
  • Publication number: UA 97513, IPC C12N 1/00 (2015.01) / Method for determining viral load / applicants: Volianskyi A., Smilianska M., Peremot S., Kashpur N., Ovcharenko S. / аpplication number: u201405696 from 26.05.2014; рublication date: 25.03.2015; newsletter № 6, 2014.
  • Publication number: UA 105324, IPC G01N 21/00 (2016.01) / Method for lymphocyte functional activity assessment using the Agilent 2100 Bioanalyzer / Volianskyi A., Smilianska M., Peremot S., Kashpur N. /аpplication number: u201509727 from 07.10.2015; рublication date: 10.03.2016; newsletter № 5, 2016.
  • Publication number: UA 112852, IPC C12N 5/02 (2006.01) / Method for increasing multiplicity of viral antigens / DNA in blood lymphocytes / Volianskyi A., Smilianska M., Peremot S., Kashpur N. /аpplication number: u201608216 from 25.07.2016; рublication date: 26.12.2016; newsletter № 24, 2016.
  • Publication number: UA 71014, IPC (2012.01) А61В 10/00; G01N 33/50 (2006.01) / Method for express estimation of vaccination efficiency / Volianskyi A., Romanova O., Kuchma I., Krestetska S. /аpplication № u201201011 from 31.01.2012; рublication date: 25.06.2012; newsletter № 12, 2012.
  • Patent number 104174 UA. IPC A61K 36/282 (2006.01) / The method of obtaining lipophilic complex of antimicrobial action of plant materials / Ochkur O.V. Kashpur N.V., Kovalova A.M., Goryacha O.V., Abdulkafarova E.R., Grudko I.V., Ilyina T.V. Volianskyi A.Yu., Koshoviy O.M. // Applicant National University of Pharmacy. - application number u2011 12757. dated 31.10.2011, published 10.01.2014, Byul. No. 1.
  • Patent number 132004 UA. IPC G01N33/53 / A method for predicting the possibility of adverse reactions to vaccination in children / M. V. Smilianska, N. V. Kashpur, S. D. Peremot, A. Yu. Volianskyi, M. V. Kuchma // Applicant DU «ІМІ NAMN». - application number u201808521. dated 06.08.2018, published 11.02.2019, Byul. No. 3.
  • Patent number 133206 UA. IPC А61К38/20 / A method for predicting the risk of potentially dangerous ventricular arrhythmias in individuals without signs of structural damage to the heart / S. D. Peremot, A. Y. Volianskyi, M. V. Smilianska, N. V. Kashpur. // Applicant: DU «ІМІ NAMN». - application number u201810658. dated 29.10.2018 , published 25.03.2019, Byul. No. 6.